Compile Data Set for Download or QSAR
Report error Found 3024 Enz. Inhib. hit(s) with Target = 'Stromelysin-1'
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12074((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50: 0.0380nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50062351((R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylc...)
Affinity DataIC50: 0.191nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50348668(CHEMBL1801056)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082556(AG-3340 | 2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benz...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082556(AG-3340 | 2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benz...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082556(AG-3340 | 2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benz...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM11874(N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxybenzene)...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant MMP3 using Cy3-PLGLK(Cy5Q)AR-NH2 as substrate after 40 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2016
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50227724(N-hydroxy-2-methyl-2-{4-[2-methyl-3'-(2-methylamin...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50592894(CHEMBL473539)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50143729((2R,3R,4R,5R)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50289127((2S,4R)-4-(3-Methyl-1-phenylcarbamoyl-butylcarbamo...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50227723(2-{4-[3'-(2-amino-ethoxy)-2-methyl-biphenyl-4-yl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50141575((2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of recombinant human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50109621([4-(4-Amino-phenoxy)-phenyl]-(3-hydroxycarbamoyl-3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50097273((R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50: 0.5nMAssay Description:Concentration required to inhibit the catalytic domain Matrix metalloprotease-3 using Nagase fluorogenic as a substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50097273((R)-N*1*-((S)-2,2-dimethyl-1-methylcarbamoyl-propy...)
Affinity DataIC50: 0.501nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-N,3,4,5-tetrahydroxy-1-(4-phenoxyphe...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-N,3,4,5-tetrahydroxy-1-(4-phenoxyphe...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of recombinant human matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.530nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063915((2R,3S)-N*4*-Hydroxy-2-isobutyl-3-methyl-N*1*-[(S)...)
Affinity DataIC50: 0.600nMAssay Description:Activity against Matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.650nMAssay Description:Activity against Matrix metalloprotease-3 (MMP-3).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50104001(4-(benzylthio)-N-hydroxy-2-(N-isobutyl-4-methoxyph...)
Affinity DataIC50: 0.700nMAssay Description:Binding affinity to MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50078566((S)-4-Benzylsulfanyl-N-hydroxy-2-[isobutyl-(4-meth...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082542((S)-7-(4-Methoxy-benzenesulfonyl)-5,5-dimethyl-[1,...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50104006(4-Benzylsulfanyl-N-hydroxy-2-[isobutyl-(4-methoxy-...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50104001(4-(benzylthio)-N-hydroxy-2-(N-isobutyl-4-methoxyph...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082537((S)-4-(4-Methoxy-benzenesulfonyl)-2,2-dimethyl-thi...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50254802(CHEMBL4088630)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of truncated human recombinant MMP3 catalytic domain expressed in Escherichia coli BL21(DE3) after 3 hrs in presence of [H]-transferrinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2019
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50082545((S)-N-hydroxy-4-(4-methoxyphenylsulfonyl)-2,2-dime...)
Affinity DataIC50: 0.708nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.730nMAssay Description:Ability to inhibit the matrix metalloprotease-3 by method of Knight et al using the fluorogenic peptide substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of MMP-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3 (MMP3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50101516(3-(3-{2-[5-(4-Chloro-phenyl)-2-hydroxycarbamoylmet...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory constant against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50283701(3-{(S)-2-[(R)-5-(4-Chloro-phenyl)-2-hydroxycarbamo...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of the stromelysin enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50287379(RS-39066 | 4-[(S)-2-((R)-2-Hydroxycarbamoylmethyl-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50103993(4-Benzylsulfanyl-N-hydroxy-2-{(4-methoxy-benzenesu...)
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to recombinant MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50183784(N*4*-(2,2-Dimethyl-1-methylcarbamoyl-propyl)-N*1*-...)
Affinity DataKi:  0.900nMAssay Description:Inhibitory potency against Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50283708(3-{(S)-2-[(R)-5-(4-Chloro-phenyl)-2-hydroxycarbamo...)
Affinity DataKi:  0.960nMAssay Description:Inhibition of the stromelysin enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50101505(3-(3-{2-[5-(4-Chloro-phenyl)-2-hydroxycarbamoylmet...)
Affinity DataKi:  0.960nMAssay Description:Inhibitory constant against matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50227709(N-hydroxy-2-(4-(4-(6-(2-hydroxyethoxy)pyridin-2-yl...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM50227725(2-{4-[3'-(2-dimethylamino-ethoxy)-2-methyl-bipheny...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
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