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Found 830 with Last Name = 'klein' and Initial = 'r'
LigandPNGBDBM50405349(CHEMBL5271837)
Affinity DataKi:  740nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405333(CHEMBL5270570)
Affinity DataKi:  744nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405348(CHEMBL5280643)
Affinity DataKi:  3.00E+3nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405346(CHEMBL5266306)
Affinity DataKi:  8.50E+4nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405336(CHEMBL5277116)
Affinity DataKi:  1.39E+5nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405334(CHEMBL5280829)
Affinity DataKi:  1.55E+5nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405329(CHEMBL5279025)
Affinity DataKi:  1.74E+5nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405337(CHEMBL5268186)
Affinity DataKi:  3.54E+5nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405328(CHEMBL5278563)
Affinity DataKi:  3.90E+5nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405341(CHEMBL5287370)
Affinity DataKi:  5.40E+5nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405343(CHEMBL5279009)
Affinity DataKi:  5.88E+5nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405340(CHEMBL5276693)
Affinity DataKi:  9.55E+5nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405347(CHEMBL5281989)
Affinity DataKi:  1.42E+6nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405342(CHEMBL5273882)
Affinity DataKi:  2.10E+6nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405344(CHEMBL5278260)
Affinity DataKi:  4.74E+6nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405331(CHEMBL5276685)
Affinity DataKi:  5.00E+6nMAssay Description:In vitro thromboxane A2 receptor antagonism through inhibition of U-46619-induced platelet aggregation in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405338(CHEMBL2393369)
Affinity DataKi:  5.00E+6nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405339(CHEMBL5286003)
Affinity DataKi:  6.22E+6nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405345(CHEMBL5273503)
Affinity DataKi:  6.38E+6nMAssay Description:In vitro inhibition of angiotensin converting enzyme isolated from rat lung.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405332(CHEMBL5285449)
Affinity DataKi:  1.00E+7nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405335(CHEMBL2357735)
Affinity DataKi:  2.00E+7nMAssay Description:In vitro inhibition of Neutral Endopeptidase isolated from rat kidney.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240277(CHEMBL4061793)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50240278(CHEMBL4062780)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434850(CHEMBL2387397)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434850(CHEMBL2387397)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [32P]S1P from human recombinant S1PR3 incubated for 60 mins by competitive binding assay based scintillation counterMore data for this Ligand-Target Pair
TargetIleal sodium/bile acid cotransporter(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434849(CHEMBL2385105 | US9040518, 6)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50420996(CHEMBL2086760)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434849(CHEMBL2385105 | US9040518, 6)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434846(CHEMBL2387399 | US9040518, 35)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of mouse ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST-tagged Flt1 using poly(Glu,Tyr) as substrate after 60 mins by alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380930(CHEMBL2016890)
Affinity DataIC50:  1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380931(CHEMBL2016886)
Affinity DataIC50:  1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380935(CHEMBL2016887)
Affinity DataIC50:  1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380929(CHEMBL2016892)
Affinity DataIC50:  1nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380939(CHEMBL2016893)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1 after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50420996(CHEMBL2086760)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Merck

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of rat Nav1.7 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -90 mV by whole-cell QPatch HT assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [32P]S1P from human recombinant S1PR1 incubated for 60 mins by competitive binding assay based scintillation counterMore data for this Ligand-Target Pair
TargetIleal sodium/bile acid cotransporter(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM47370(BDBM50434858 | US9040518, 26)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of rat ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380932(CHEMBL2016771)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434848(CHEMBL2387520)
Affinity DataIC50:  2nMAssay Description:Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380936(CHEMBL2016888)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380937(CHEMBL2016889)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380938(CHEMBL2016891)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380939(CHEMBL2016893)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50379530(CHEMBL2012701)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50379531(CHEMBL2012702)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380934(CHEMBL2016885)
Affinity DataIC50:  2nMAssay Description:Inhibition of p70S6K after 3 hrs by luciferase based chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIleal sodium/bile acid cotransporter(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50434847(CHEMBL2387421 | US9040518, 3)
Affinity DataIC50:  2nMAssay Description:Inhibition of human ASBT expressed in HEK293 cells assessed as inhibition of [3H]-taurocholate uptake after 90 mins by scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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