TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataKi: 740nMAssay Description:Uncompetitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataKi: 3.50E+3nMAssay Description:Competitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM A...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 100 uM ATP as subst...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: <200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: <200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: <200nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 300nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 300nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: >300nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 300nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 340nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 350nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 390nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 400nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 400nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 450nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 100 uM ATP as subst...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 500nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: <500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 600nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh
Curated by ChEMBL
University Of Pittsburgh
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 800nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology
US Patent
California Institute of Technology
US Patent
Affinity DataIC50: 800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair