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Found 364 with Last Name = 'deshaies' and Initial = 'rj'
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50558084(CHEMBL4799933)
Affinity DataKi:  740nMAssay Description:Uncompetitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50558084(CHEMBL4799933)
Affinity DataKi:  3.50E+3nMAssay Description:Competitive inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 20 uM A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50424917(CHEMBL2311578)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 100 uM ATP as subst...More data for this Ligand-Target Pair
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401033(US10005735, Compound 31)
Affinity DataIC50:  170nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401021(US10005735, Compound 20)
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM400994(US10005735, Compound 7)
Affinity DataIC50:  200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401033(US10005735, Compound 31)
Affinity DataIC50:  200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401008(US10005735, Compound 17)
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264415(CHEMBL4096289)
Affinity DataIC50: <200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50:  200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401006(US10005735, Compound 15)
Affinity DataIC50:  200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264457(CHEMBL4080490)
Affinity DataIC50: <200nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTAM-binding protein(Homo sapiens (Human))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264455(CHEMBL4060337)
Affinity DataIC50: <200nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401020(US10005735, Compound 19)
Affinity DataIC50: <200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50562854(CHEMBL4763993)
Affinity DataIC50:  200nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264420(CHEMBL4100384)
Affinity DataIC50:  300nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM400998(US10005735, Compound 11)
Affinity DataIC50:  300nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264482(CHEMBL4086748)
Affinity DataIC50: >300nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264453(CHEMBL4088568)
Affinity DataIC50:  300nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  340nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays were performed in low-volume 384-well solid black plates (Molecular Devices) in quadruplicate. The assays were perfo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM224012(Capzimin | US10005735, Compound 12)
Affinity DataIC50:  340nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401023(US10005735, Compound 21)
Affinity DataIC50:  350nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  390nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264515(CHEMBL4070821)
Affinity DataIC50:  400nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401034(US10005735, Compound 32)
Affinity DataIC50:  400nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401034(US10005735, Compound 32)
Affinity DataIC50:  400nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM400992(US10005735, Compound 5)
Affinity DataIC50:  450nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401006(US10005735, Compound 15)
Affinity DataIC50:  500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264415(CHEMBL4096289)
Affinity DataIC50:  500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50558084(CHEMBL4799933)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human full length Avi-tagged p97 (1 to 806 residues) expressed in Escherichia coli Rosetta 2(DE3) using 100 uM ATP as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264471(CHEMBL4093962)
Affinity DataIC50:  500nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM400996(US10005735, Compound 9)
Affinity DataIC50:  500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401029(US10005735, Compound 27)
Affinity DataIC50:  500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401029(US10005735, Compound 27)
Affinity DataIC50:  500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSTAM-binding protein(Homo sapiens (Human))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264417(CHEMBL4104719)
Affinity DataIC50:  500nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401020(US10005735, Compound 19)
Affinity DataIC50:  500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCOP9 signalosome complex subunit 5(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264426(CHEMBL4095913)
Affinity DataIC50: <500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSTAM-binding protein(Homo sapiens (Human))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50264415(CHEMBL4096289)
Affinity DataIC50:  600nMAssay Description:Inhibition of AMSH (unknown origin) using DiUbK63TAMRA as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264419(CHEMBL4073553)
Affinity DataIC50:  600nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in beta5 inhibitor MG132 pretreated human HeLa cells expressing UbG76...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401020(US10005735, Compound 19)
Affinity DataIC50:  600nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50562860(CHEMBL4762311)
Affinity DataIC50:  600nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401030(US10005735, Compound 28)
Affinity DataIC50:  700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAMSH-like protease(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401030(US10005735, Compound 28)
Affinity DataIC50:  700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401009(US10005735, Compound 18)
Affinity DataIC50:  700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM401026(US10005735, Compound 24)
Affinity DataIC50:  700nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50562857(CHEMBL4791813)
Affinity DataIC50:  700nMAssay Description:Inhibition of His6-tagged p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATPase activity measured after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264483(CHEMBL4105598)
Affinity DataIC50:  800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM400995(US10005735, Compound 8)
Affinity DataIC50:  800nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264416(CHEMBL4069023)
Affinity DataIC50:  800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target26S proteasome non-ATPase regulatory subunit 14(Homo sapiens (Human))
California Institute of Technology

US Patent
LigandPNGBDBM50264453(CHEMBL4088568)
Affinity DataIC50:  800nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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