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Found 110 with Last Name = 'feenstra' and Initial = 'rw'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302220(7-((1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103826(7-[4-(6-Hydroxy-biphenyl-3-ylmethyl)-piperazin-1-y...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50020174(1-Benzofuran-7-yl-4-[5-(4-fluoro-phenyl)-1H-pyrrol...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103839(7-{4-[4-(4-Fluoro-phenyl)-pyridin-2-ylmethyl]-pipe...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103840(1-Biphenyl-3-ylmethyl-4-(2,3-dihydro-benzo[1,4]dio...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103830(8-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3,4-dihyd...)
Affinity DataKi:  0.930nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103841(8-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-4H-benzo[...)
Affinity DataKi:  1nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019960(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  1nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103835(7-[4-(3-Thiophen-3-yl-benzyl)-piperazin-1-yl]-3H-b...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50020174(1-Benzofuran-7-yl-4-[5-(4-fluoro-phenyl)-1H-pyrrol...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103840(1-Biphenyl-3-ylmethyl-4-(2,3-dihydro-benzo[1,4]dio...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103843(7-[4-(5-Phenyl-pyridin-3-ylmethyl)-piperazin-1-yl]...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103847(3'-[4-(2-Oxo-2,3-dihydro-benzooxazol-7-yl)-piperaz...)
Affinity DataKi:  2nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  2nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103831(7-[4-(3-Thiophen-2-yl-benzyl)-piperazin-1-yl]-3H-b...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50241119(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103846(7-{4-[2-(4-Fluoro-phenyl)-pyridin-4-ylmethyl]-pipe...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103827(7-{4-[6-(4-Fluoro-phenyl)-pyridin-2-ylmethyl]-pipe...)
Affinity DataKi:  3nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302218(7-(1-((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-3-y...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103844(5-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-1,2,3,4-t...)
Affinity DataKi:  4nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103834(4-Fluoro-N-{2-[4-(2-oxo-2,3-dihydro-benzooxazol-7-...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50019960(4-Fluoro-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl...)
Affinity DataKi:  5nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103828(3'-[4-(2-Oxo-2,3-dihydro-benzooxazol-7-yl)-piperaz...)
Affinity DataKi:  6nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302212((3S)-3-((3-( 6-fluoro-2,3,4,9-tetrahydro-1H-carbaz...)
Affinity DataKi:  6nMAssay Description:Agonist activity at 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302213((3S)-3-(((6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103826(7-[4-(6-Hydroxy-biphenyl-3-ylmethyl)-piperazin-1-y...)
Affinity DataKi:  7.60nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103843(7-[4-(5-Phenyl-pyridin-3-ylmethyl)-piperazin-1-yl]...)
Affinity DataKi:  7.80nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103834(4-Fluoro-N-{2-[4-(2-oxo-2,3-dihydro-benzooxazol-7-...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103832(1-Benzofuran-7-yl-4-biphenyl-3-ylmethyl-piperazine...)
Affinity DataKi:  8.10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103833(7-[4-(4'-Fluoro-biphenyl-3-ylmethyl)-piperazin-1-y...)
Affinity DataKi:  8.10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50241119(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Affinity DataKi:  9.30nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103838(7-[4-(3'-Methyl-biphenyl-3-ylmethyl)-piperazin-1-y...)
Affinity DataKi:  9.30nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50302221(7-((1-(2-(6-fluoro-2,3,4,9-tetrahydro-1H-carbazol-...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103836(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3-methyl-...)
Affinity DataKi:  10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103842(1-Benzo[1,3]dioxol-4-yl-4-biphenyl-3-ylmethyl-pipe...)
Affinity DataKi:  10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103848(7-[4-(3'-Methoxy-biphenyl-3-ylmethyl)-piperazin-1-...)
Affinity DataKi:  10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103837(7-[4-(4-Fluoro-biphenyl-3-ylmethyl)-piperazin-1-yl...)
Affinity DataKi:  12nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50378462(CHEMBL1237149)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103833(7-[4-(4'-Fluoro-biphenyl-3-ylmethyl)-piperazin-1-y...)
Affinity DataKi:  14nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50302224(7-((1R,4R)-5-((6-fluoro-2,3,4,9-tetrahydro-1H-carb...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]spiperone from D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Solvay Pharma

Curated by ChEMBL
LigandPNGBDBM50103842(1-Benzo[1,3]dioxol-4-yl-4-biphenyl-3-ylmethyl-pipe...)
Affinity DataKi:  15nMAssay Description:Binding affinity for 5-hydroxytryptamine 1A receptor determined using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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