Found 376 with Last Name = 'arancio' and Initial = 'o' 
Affinity DataKi: 40nMAssay Description:Inhibitory activity against HIV-1 Y181C reverse transcriptase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 86nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 91nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 98nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 100nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 100nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 101nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 101nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 110nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase G190AMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 114nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 127nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 180nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase P236LMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 184nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 186nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 276nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 343nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 620nMAssay Description:Inhibitory activity against HIV-1 Mutant Reverse transcriptase K103NMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataKi: 657nMAssay Description:The concentration dependent ability of compounds to inhibit human p38α MAPK, p38β MAPK and CK-1δ were done essentially as described in...More data for this Ligand-Target Pair
Affinity DataKi: 1.62E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2.59E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2.60E+3nM ΔG°: -32.4kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2.89E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 2.90E+3nM ΔG°: -32.1kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.50E+3nM ΔG°: -31.7kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.53E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 3.96E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 4.00E+3nM ΔG°: -31.3kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
Affinity DataKi: 5.08E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.31E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 6.00E+3nM ΔG°: -30.3kJ/molepH: 7.6 T: 2°CAssay Description:Full length porcine calpain (156 nM), or papain (236 pM) was added to a solution of 100 mM NaCl, 50 mM HEPES, pH 7.6, 1 mM TCEP, 30 μM Suc-LLVY-AM...More data for this Ligand-Target Pair
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Illinois College Of Pharmacy
Curated by ChEMBL
University Of Illinois College Of Pharmacy
Curated by ChEMBL
Affinity DataKi: 6.02E+3nMAssay Description:Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.70E+3nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.92E+4nMAssay Description:Inhibition of papain after using SucLLVYAMC as substrate by FRET assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0440nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0440nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0560nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0560nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0560nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0590nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0590nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0700nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.0700nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.190nMAssay Description:Inhibition of human recombinant PDE5A1 using FAM-labelled cGMP as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.200nMAssay Description:Materials and Methods: PDE5 inhibition was assayed at BPS Bioscience (San Diego, Calif.) using BPS PDE assay kits (BPS Catalog number 60300, enzyme l...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.200nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.277nMAssay Description:Inhibition of PDE5 (unknown origin) using FAM-cGMP as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.290nMAssay Description:Inhibition of adenylate cyclase via Adenosine A1 receptor in rat fat cell membranesMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.290nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
The Trustees of Columbia University In The City of New York
US Patent
The Trustees of Columbia University In The City of New York
US Patent
Affinity DataIC50: 0.320nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
