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Found 175 with Last Name = 'beutler' and Initial = 'j'
TargetProtein kinase C alpha/beta/gamma/delta/epsilon/eta/theta type/Serine/threonine-protein kinase D1/D3(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50368315(PROSTRATIN)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]PDBu binding to Protein kinase C of CEM cells with 10% fetal calf serumMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494419(Tetrahydrobungeanool)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482161(CHEMBL1082256)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482160(CHEMBL1082257)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482160(CHEMBL1082257)
Affinity DataIC50:  6nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482161(CHEMBL1082256)
Affinity DataIC50:  8nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494416(CHEMBL2335715 | Hydroxy-Beta-Sanshool)
Affinity DataIC50:  9nMAssay Description:Displacement of [3H]-Win55212-2 from human CB1 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Rattus norvegicus)
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50478518(CHEMBL514017)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]PDBu from rat brain membrane PKCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295171(AILANTHINONE | CHEMBL487194)
Affinity DataIC50:  32nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50349194(GLAUCARUBINONE | NSC-14975)
Affinity DataIC50:  40nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494422(CHEMBL3086847)
Affinity DataIC50:  41nMAssay Description:Displacement of [3H]-Win55212-2 from human CB1 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50318477(CHEMBL1084610 | Hydroxy-alpha-sanshool)
Affinity DataIC50:  59nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Jun(Homo sapiens (Human))
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50295170(6R-senecionylchaparrin | CHEMBL564009)
Affinity DataIC50:  71nMAssay Description:Inhibition of TPA-induced AP1 transfected in HEK293 cells assessed as inhibition of beta-lactamase reporter activity treated 1 hr before TPA stimulat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494417(CHEMBL3086844)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]-Win55212-2 from human CB1 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494416(CHEMBL2335715 | Hydroxy-Beta-Sanshool)
Affinity DataIC50:  131nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494422(CHEMBL3086847)
Affinity DataIC50:  168nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494421(CHEBI:81359 | CHEMBL3086846)
Affinity DataIC50:  184nMAssay Description:Displacement of [3H]-Win55212-2 from human CB1 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494421(CHEBI:81359 | CHEMBL3086846)
Affinity DataIC50:  197nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  210nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494420(CHEMBL3086845)
Affinity DataIC50:  224nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484003(CHEMBL1802249)
Affinity DataIC50:  240nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 2)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  250nMAssay Description:Inhibition of RNase H activity of HIV-2 reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492114(CHEMBL2397283)
Affinity DataIC50:  260nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM33411(β-Thujaplicinol | hydroxytropolone, 3)
Affinity DataIC50:  260nMAssay Description:Inhibition of human immunodeficiency virus-1 reverse transcriptase associated RNase H activity using using 18-nucleotide 3,-fluorescein-labeled RNA s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492104(CHEMBL2397405)
Affinity DataIC50:  260nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492105(CHEMBL2397404)
Affinity DataIC50:  290nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492128(CHEMBL2397402)
Affinity DataIC50:  320nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492132(CHEMBL2397403)
Affinity DataIC50:  370nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484009(CHEMBL1802246)
Affinity DataIC50:  380nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50480466(CHEMBL541369)
Affinity DataIC50:  410nMAssay Description:Inhibition of HIV1 recombinant integrase by electrochemiluminescent-based high-throughput strand transfer assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492120(CHEMBL2397400)
Affinity DataIC50:  420nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492129(CHEMBL2397393)
Affinity DataIC50:  480nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492107(CHEMBL2397399)
Affinity DataIC50:  490nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50482161(CHEMBL1082256)
Affinity DataIC50: >500nMAssay Description:Inhibition of HIV1 reverse transcriptase-associated ribonuclease H activity by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50482160(CHEMBL1082257)
Affinity DataIC50: >500nMAssay Description:Inhibition of HIV1 reverse transcriptase-associated ribonuclease H activity by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484014(CHEMBL1802034)
Affinity DataIC50:  500nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484004(CHEMBL1802251)
Affinity DataIC50:  510nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492106(CHEMBL2397401)
Affinity DataIC50:  590nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484017(CHEMBL1802031)
Affinity DataIC50:  600nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
National Institute On Aging

Curated by ChEMBL
LigandPNGBDBM50494417(CHEMBL3086844)
Affinity DataIC50:  664nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells preincubated for 1 hr followed by radioligand addition measured after 1 h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484015(CHEMBL1802253)
Affinity DataIC50:  680nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492134(CHEMBL2397413)
Affinity DataIC50:  690nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482159(CHEMBL1082255)
Affinity DataIC50:  700nMAssay Description:Inhibition of HIV1 integrase strand transfer activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50492125(CHEMBL2397277)
Affinity DataIC50:  790nMAssay Description:Inhibition of RNase H activity of wild type HIV-1 reverse transcriptase using 18 nucleotide 3'-fluorescein-labeled RNA/18 nucleotide 5'-dabsyl-labele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484005(CHEMBL1802032)
Affinity DataIC50:  820nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482159(CHEMBL1082255)
Affinity DataIC50:  830nMAssay Description:Inhibition of HIV1 integrase 3'-end processing activity after 1 hr by densitometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgrammed cell death protein 4(Homo sapiens (Human))
Yunnan University

Curated by ChEMBL
LigandPNGBDBM50000298('2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROX...)
Affinity DataIC50:  880nMAssay Description:Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484006(CHEMBL1802247)
Affinity DataIC50:  930nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50484012(CHEMBL1802254)
Affinity DataIC50:  960nMAssay Description:Inhibition of RNase H activity of his6-tagged HIV1 HXB2 reverse transcriptase p66/p51 expressed in Escherichia coli assessed as substrate cleavage at...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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