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Found 406 with Last Name = 'bohacek' and Initial = 'r'
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006111((ZFPLA) 2-[2-(2-Benzyloxycarbonylamino-3-phenyl-pr...)
Affinity DataKi:  0.0680nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhizopuspepsin(Rhizopus microsporus var. chinensis)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50070005(((3R,6R,15R)-15-Hydroxymethyl-3-isopropyl-2,5-diox...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for potency towards nicotinic acetylcholine receptor in rat P2 brain membranes using [3H]-nicotine as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006110((ZGPLA) 2-[2-(2-Benzyloxycarbonylamino-acetylamino...)
Affinity DataKi:  9.10nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataKi:  28nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
TargetDiphosphomevalonate decarboxylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287714((3R)-3-(fluoromethyl)-3-hydroxy-5-{[(phosphonatoox...)
Affinity DataKi:  37nMAssay Description:Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006117((CLT) 2-{1-[1-Carboxy-2-(1H-indol-3-yl)-ethylcarba...)
Affinity DataKi:  50nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhizopuspepsin(Rhizopus microsporus var. chinensis)
University Of Wisconsin-Madison

Curated by ChEMBL
LigandPNGBDBM50070006(((Z)-(3R,6R,15R)-15-Hydroxymethyl-3-isopropyl-2,5-...)
Affinity DataKi:  336nMAssay Description:Compound was evaluated for inhibitory activity towards nicotinic acetylcholine receptor in rat P2 brain membranes using [3H]-nicotine as a radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006114((HONH-BAGN) N-(1-{[(4-Nitro-phenylcarbamoyl)-methy...)
Affinity DataKi:  430nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiphosphomevalonate decarboxylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287713([methyl(2-{[(phosphonatooxy)phosphinato]oxy}ethyl)...)
Affinity DataKi:  750nMAssay Description:Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006113((BAG)2-Benzyl-N-[1-(carbamoylmethyl-carbamoyl)-eth...)
Affinity DataKi:  750nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006115((R)-RETRO-THIORPHAN | (RETRO)N-(1-Mercaptomethyl-2...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006116((ZGP(O)LL)Cbz-Glyp-(O)-L-Leu-L-Leu | CHEMBL48051)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50006112(((S)-1-Carbamoyl-3-methyl-butyl)-phosphoramidic ac...)
Affinity DataKi:  2.13E+4nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132351(({4-[6-(2,6-Dichloro-phenyl)-8-(3-dimethylamino-pr...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50314074(2,6,9-Trisubstitute purine, 6 (AP23464) | 3-(2-(2-...)
Affinity DataIC50:  0.450nMpH: 7.4 T: 2°CAssay Description:Inhibition of human Src kinase activity by ARIAD compounds were measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042828(4-Hydroxy-1-(9-mercaptomethyl-10-oxo-azecane-2-car...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056252((6S,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107639(3-{2-[2-(4-Chloro-2-fluoro-benzoylamino)-3-m-tolyl...)
Affinity DataIC50:  2nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042835(1-(9-Mercaptomethyl-10-oxo-azecane-2-carbonyl)-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132348(({4-[6-(2,6-Dichloro-phenyl)-8-methyl-7-oxo-7,8-di...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  3nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056249((6S,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042827(9-Mercaptomethyl-10-oxo-azecane-2-carboxylic acid ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132322(({2-[(2-{4-[4-Amino-5-(3-hydroxy-phenyl)-pyrrolo[2...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of Src protein tryrosine kinase using the Scintillation proximity kinase assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056262((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit Angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27216((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056259((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[11.3....)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056251((6R,9S)-6-Mercaptomethyl-7-oxo-5,6,7,8,9,10,11,12,...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107633(3-[2-Cyano-2-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107646(3-[4-Cyano-4-(2-diphenylacetylamino-3-m-tolyl-prop...)
Affinity DataIC50:  5.60nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107623(CHEMBL140756 | N-Cyanomethyl-2-diphenylacetylamino...)
Affinity DataIC50:  6nMAssay Description:Inhibitiory activity of the compound against recombinant human cathepsin L (cat L) expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107626(3-{(R)-2-Cyano-2-[(S)-2-(2,4-difluoro-benzoylamino...)
Affinity DataIC50:  6.80nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056247((6R,9S)-6-Mercaptomethyl-7-oxo-6,7,8,9,10,11,12,13...)
Affinity DataIC50:  7nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50056262((3S,6S)-3-Mercaptomethyl-4-oxo-5-aza-bicyclo[10.3....)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration required to inhibit neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiphosphomevalonate decarboxylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287710((2S)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107620(3-[2-(2-Benzoylamino-3-m-tolyl-propionylamino)-2-c...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107638(CHEMBL336436 | N-(Benzyloxymethyl-cyano-methyl)-2-...)
Affinity DataIC50:  10.2nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042832(3-Hydroxy-2-[(9-mercaptomethyl-10-oxo-azecane-2-ca...)
Affinity DataIC50:  11nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50107650(CHEMBL138661 | N-Cyanomethyl-3-(3,5-dimethyl-pheny...)
Affinity DataIC50:  11.9nMAssay Description:Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042831(6-Amino-2-[(9-mercaptomethyl-10-oxo-azecane-2-carb...)
Affinity DataIC50:  14nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiphosphomevalonate decarboxylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287715((2R)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)
Affinity DataIC50:  15nMAssay Description:Compound was evaluated for its inhibitory activity against MevPP decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDiphosphomevalonate decarboxylase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287715((2R)-1-({[(phosphonatooxy)phosphinato]oxy}acetyl)p...)
Affinity DataIC50:  15nMAssay Description:Compound was evaluated for its inhibitory activity against Mevalonate 5-pyrophosphate decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3071(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 38 | 2-ani...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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