Compile Data Set for Download or QSAR
maximum 50k data
Found 120 with Last Name = 'bryant' and Initial = 'jw'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077930(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077933(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.160nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077934(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(2-morp...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077935(CHEMBL308646 | {5-[4-Benzo[1,3]dioxol-5-yl-2-hydro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077936(4-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077946(5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-metho...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328728((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  0.380nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077944(CHEMBL408055 | Sodium; 3-{5-[4-benzo[1,3]dioxol-5-...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against renin in fluorescent tGFP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17965(N-[2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]p...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077941(3-Benzo[1,3]dioxol-5-yl-4-[3,4-dimethoxy-5-(3-morp...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81692(4-Substituted Pyrrolidine Ring, 14)
Affinity DataIC50:  0.75nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81698(4-Substituted Pyrrolidine Ring, 35)
Affinity DataIC50:  1nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077943(3-Benzo[1,3]dioxol-5-yl-4-[3-(3-dimethylamino-prop...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81693(4-Substituted Pyrrolidine Ring, 16 | 4-Substituted...)
Affinity DataIC50:  1.20nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328726((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  1.70nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077947(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077938(3-Benzo[1,3]dioxol-5-yl-4-{3,4-dimethoxy-5-[3-(4-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077945(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-dimethylamino-etho...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81695(4-Substituted Pyrrolidine Ring, 20)
Affinity DataIC50:  2.90nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077942(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81697(4-Substituted Pyrrolidine Ring, 34)
Affinity DataIC50:  4.30nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81696(4-Substituted Pyrrolidine Ring, 21)
Affinity DataIC50:  5nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328728((2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methy...)
Affinity DataIC50:  6.10nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18031(CHEMBL193816 | Ketopiperazine-based inhibitor, 11)
Affinity DataIC50:  7nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81693(4-Substituted Pyrrolidine Ring, 16 | 4-Substituted...)
Affinity DataIC50:  7nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81699(4-Substituted Pyrrolidine Ring, 36)
Affinity DataIC50:  7.60nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077931(CHEMBL70017 | {5-[4-Benzo[1,3]dioxol-5-yl-2-hydrox...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077937(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077939(3-Benzo[1,3]dioxol-5-yl-4-[3,5-bis-(2-morpholin-4-...)
Affinity DataIC50: >10nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077928(3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165800(7-((S)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phen...)
Affinity DataIC50:  17nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328725((R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-sulfamoylb...)
Affinity DataIC50:  18nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165796((S)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phenyl}...)
Affinity DataIC50:  23nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077929(3-Benzo[1,3]dioxol-5-yl-4-[3-(2-dimethylamino-etho...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50077940(3-Benzo[1,3]dioxol-5-yl-4-[3-(3-dimethylamino-prop...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM81681(P1 Phenyl Ring, 22)
Affinity DataIC50:  33nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165802((S)-6-[1-(2-Hydroxy-ethyl)-1,2,3,4-tetrahydro-quin...)
Affinity DataIC50:  33nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165804((S)-6-[1-(3-Hydroxy-propyl)-1,2,3,4-tetrahydro-qui...)
Affinity DataIC50:  35nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50328725((R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-sulfamoylb...)
Affinity DataIC50:  36nMAssay Description:FXa inhibition were determined by using an inhibition assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18029((6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroqu...)
Affinity DataIC50:  37nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17966((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50:  54nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17966((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50:  54nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165803((R)-6-[1-(2-Hydroxy-ethyl)-1,2,3,4-tetrahydro-quin...)
Affinity DataIC50:  64nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165798((S)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phenyl}...)
Affinity DataIC50:  66nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50165799((R)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phenyl}...)
Affinity DataIC50:  120nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50173065((R)-1-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phenyl}...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against renin in fluorescent tGFP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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