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Found 98 with Last Name = 'buck' and Initial = 'e'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM383((3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-...)
Affinity DataIC50:  0.0600nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283953(CHEMBL357039 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1...)
Affinity DataIC50:  1.80nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282598((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282605((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282602((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282606((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339062(4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...)
Affinity DataIC50:  8nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282607((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282603((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282597((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283954(CHEMBL146361 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339064(5-(8-fluoro-2-phenylquinolin-7-yl)-7-(3-(4-methylp...)
Affinity DataIC50:  14nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283957(CHEMBL146875 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1...)
Affinity DataIC50:  17nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(CHEMBL1667935 | cis-3-[4-Amino-5-(8-fluoro-2-pheny...)
Affinity DataIC50:  17nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282601((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339063(7-(3-(4-methylpiperazin-1-yl)cyclobutyl)-5-(2-phen...)
Affinity DataIC50:  25nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339061(4-(3-(4-amino-5-(2-phenylquinolin-7-yl)imidazo[1,5...)
Affinity DataIC50:  26nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282604((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283958(CHEMBL148090 | {(1S,2S)-1-Benzyl-3-[(S)-3-benzyl-1...)
Affinity DataIC50:  35nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024694((S)-6-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethy...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282599((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50403366(CHEMBL2062145 | L-687630)
Affinity DataIC50:  37nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282610((3S,4S)-5-Cyclohexyl-3-hydroxy-4-((S)-4-methyl-2-{...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282600((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339062(4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...)
Affinity DataIC50:  48nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282596(4-[(3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-di...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339064(5-(8-fluoro-2-phenylquinolin-7-yl)-7-(3-(4-methylp...)
Affinity DataIC50:  68nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(CHEMBL1667935 | cis-3-[4-Amino-5-(8-fluoro-2-pheny...)
Affinity DataIC50:  76nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human IGF1R in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  86nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282609((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283956(CHEMBL356749 | [(1S,2S)-1-Benzyl-3-((S)-3-benzyl-1...)
Affinity DataIC50:  111nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024698(6-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024687((+/-)-6-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymet...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339060(CHEMBL1688359 | cis-3-(4-amino-5-(2-phenylquinolin...)
Affinity DataIC50:  150nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282608((3S,4S)-5-Cyclohexyl-4-((S)-2-{(S)-2-[2-(1,1-dioxo...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human plasma renin at pH 65.0More data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023004(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  180nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023001(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  200nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339061(4-(3-(4-amino-5-(2-phenylquinolin-7-yl)imidazo[1,5...)
Affinity DataIC50:  260nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339058(7-cyclobutyl-5-(2-phenylquinolin-7-yl)imidazo[1,5-...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human IGF1R in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339063(7-(3-(4-methylpiperazin-1-yl)cyclobutyl)-5-(2-phen...)
Affinity DataIC50:  320nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339058(7-cyclobutyl-5-(2-phenylquinolin-7-yl)imidazo[1,5-...)
Affinity DataIC50:  330nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024688(9-Imidazol-1-yl-8-(4-methoxy-benzyloxymethyl)-non-...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024685((R)-6-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethy...)
Affinity DataIC50:  420nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023002(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  540nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023002(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  540nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50024693(6-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  560nMAssay Description:Inhibition of Thromboxane B2 formation in collagen-stimulated human platelets in platelet rich plasma.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023016(4-[2-Imidazol-1-yl-1-(4-methoxy-benzyloxymethyl)-e...)
Affinity DataIC50:  560nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339060(CHEMBL1688359 | cis-3-(4-amino-5-(2-phenylquinolin...)
Affinity DataIC50:  700nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50023017(CHEMBL41231 | ethyl 4-[2-(4-ethyloxycarbonylbenzyl...)
Affinity DataIC50:  700nMAssay Description:Tested for inhibitory activity against intact human platelet TXA2 formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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