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Found 70 with Last Name = 'cataldi' and Initial = 'a'
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036734((S)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM50009307(DITOLYLGUANIDINE | Di-o-tolylguanidine)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036734((S)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059789(CHEMBL3393789)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059787(CHEMBL3393790)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma 1 receptor guinea pig brain membranes incubated for 150 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  256nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036734((S)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  353nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50036738((R)-4-(4-Chloro-phenyl)-1-[4-(4-fluoro-phenyl)-4-h...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059787(CHEMBL3393790)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059789(CHEMBL3393789)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059787(CHEMBL3393790)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]-7-OH-DPAT from dopamine D3 receptor in rat olfactory tubercle by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50059789(CHEMBL3393789)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [3H]-spiperone from dopamine D2 receptor in rat striatum by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM13061(4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitr...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of aromatase in human MCF-7aro cells using [1beta-3H] androstenedione as substrate incubated for 1 hr by liquid scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetNitric oxide synthase, inducible(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50543107(CHEMBL4633346)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant N-terminal His-tagged human iNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50401339(CHEMBL4161447)
Affinity DataIC50:  58nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50226527(CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant N-terminal His-tagged human iNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50226527(CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...)
Affinity DataIC50:  101nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50504788(CHEMBL4537791)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluorime...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403157(CHEMBL4171271)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50504787(CHEMBL1371590)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluorime...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403472(CHEMBL4169004)
Affinity DataIC50:  253nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403162(CHEMBL4160671)
Affinity DataIC50:  276nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50095298(CHEMBL3589087)
Affinity DataIC50:  428nMAssay Description:Inhibition of recombinant N-terminal His-tagged human iNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403160(CHEMBL4169649)
Affinity DataIC50:  446nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403161(CHEMBL4177347)
Affinity DataIC50:  450nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50504786(CHEMBL4516755)
Affinity DataIC50:  490nMAssay Description:Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluorime...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403159(CHEMBL4173076)
Affinity DataIC50:  534nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50543108(CHEMBL4635568)
Affinity DataIC50:  681nMAssay Description:Inhibition of recombinant N-terminal His-tagged human iNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50504789(CHEMBL4464506)
Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluorime...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50570215(CHEMBL4858552)
Affinity DataIC50:  820nMAssay Description:Inhibition of human CYP19A measured every 1 min for 60 mins by flourimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50570216(CHEMBL4874326)
Affinity DataIC50:  860nMAssay Description:Inhibition of human CYP19A measured every 1 min for 60 mins by flourimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403156(CHEMBL4176848)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403464(CHEMBL4166234)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50573759(CHEMBL4870604)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50573760(CHEMBL4868867)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50210930(CHEMBL3924170)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human aromatase in T47D measured after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50543107(CHEMBL4633346)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins followed by NADPH addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50226527(CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of recombinant rat nNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, brain(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50226527(CHEMBL107251 | N-(3-(AMINOMETHYL)BENZYL)ACETAMIDIN...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of recombinant human nNOS expressed in Escherichia coli using L-arginine as substrate preincubated for 15 mins followed by NADPH addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50573758(CHEMBL4847316)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
"G. D'Annunzio" University

Curated by ChEMBL
LigandPNGBDBM50345657(CHEMBL1784801 | rac-3-((1H-imidazol-1-yl)methyl)-1...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403464(CHEMBL4166234)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant bovine eNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
University "G. D'Annunzio" Of Chieti-Pescara

Curated by ChEMBL
LigandPNGBDBM50543107(CHEMBL4633346)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human eNOS using L-argininge as substrate preincubated for 15 mins followed by NADPH addition and measured after 20 mins by OPA/NAC rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403158(CHEMBL4163633)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50400786(CHEMBL4171037)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
University Of Chieti "G. D'Annunzio

Curated by ChEMBL
LigandPNGBDBM50403471(CHEMBL4161080)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant mouse iNOS using [3H]L-arginine as substrate preincubated for 15 mins followed by NADPH addition measured after 20 mins in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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