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Found 425 with Last Name = 'cecchetti' and Initial = 'o'
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195108((S)-N8-hydroxy-2-(2-(5-methoxy-2-methyl-1H-indol-3...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC7More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50175036(CHEMBL3809599)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells preincubated for 10 mins followed by addition of FLUOR DE LYS as fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195108((S)-N8-hydroxy-2-(2-(5-methoxy-2-methyl-1H-indol-3...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of HDAC3 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195108((S)-N8-hydroxy-2-(2-(5-methoxy-2-methyl-1H-indol-3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HDAC2 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25168(2-N-hydroxy-5-N-[(1R)-1-phenylethyl]thiophene-2,5-...)
Affinity DataIC50:  6nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50245989(1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25168(2-N-hydroxy-5-N-[(1R)-1-phenylethyl]thiophene-2,5-...)
Affinity DataIC50:  10nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258574((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258574((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  13nMAssay Description:Inhibition of HDAC6 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  14nMAssay Description:Inhibition of HDAC3 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25172(1-[5-(2,3-dihydro-1H-indol-1-ylcarbonyl)thiophen-2...)
Affinity DataIC50:  15nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50245988(4-((5-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)-1,2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50245986(2,2,2-trifluoro-1-(5-(3-(thiophen-2-ylmethyl)-1,2,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275647((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  17nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195119((S)-N-(biphenyl-3-yl)-2-(2-(5-methoxy-2-methyl-1H-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195129((S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50:  23nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195118((S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275647((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  27nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50:  29nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50246033(2,2,2-Trifluoro-1-(5-{3-[(methylsulfonyl)methyl]-1...)
Affinity DataIC50:  30nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50246034(2,2,2-Trifluoro-1-(5-{3-[(propylsulfonyl)methyl]-1...)
Affinity DataIC50:  30nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195111((S)-N-(1-(3-methoxyphenylamino)-1,8-dioxononan-2-y...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50246035(2,2,2-Trifluoro-1-(5-{3-[(thiophen-2-ylsulfonyl)me...)
Affinity DataIC50:  35nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  43nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  44nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195135((S)-N-(3-chlorophenyl)-2-(2-(5-methoxy-2-methyl-1H...)
Affinity DataIC50:  44nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195108((S)-N8-hydroxy-2-(2-(5-methoxy-2-methyl-1H-indol-3...)
Affinity DataIC50:  45nMAssay Description:Inhibition of HDAC6 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275542((S)-N-(1-(5-(biphenyl-4-yl)-1H-imidazol-2-yl)-7-ox...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50195130((S)-N-(1-(biphenyl-3-ylamino)-1,8-dioxononan-2-yl)...)
Affinity DataIC50:  55nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25144((2S)-2-[(1-methylpiperidin-2-yl)formamido]-8-oxo-N...)
Affinity DataIC50:  55nMAssay Description:Inhibition of HDAC1 (mean IC50)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275995((S)-3-nitro-N-(7-oxo-1-(5-phenyl-1H-imidazol-2-yl)...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant C-terminally flag tagged HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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