Affinity DataKi: 0.0130nM ΔG°: -61.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0140nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.0900nMAssay Description:Receptor binding affinity towards opioid receptor kappaMore data for this Ligand-Target Pair
Affinity DataKi: 0.0900nM ΔG°: -56.8kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nM ΔG°: -56.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.150nM ΔG°: -55.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of activated human coagulation factor 11 using pyroGlu-Pro-Arg-pNA as substrate incubated for 10 to 120 mins by spectrofluorometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nM ΔG°: -55.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nM Kon: 4.90M-1s-1 Koff: 3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nM ΔG°: -55.2kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.180nMAssay Description:Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nM ΔG°: -54.9kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Receptor binding affinity towards opioid receptor kappaMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.240nMAssay Description:Displacement of [3H]-U-69,593 from kappa opioid receptors in guine pig brain (minus cerebellum).More data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Inhibition of human factor11a using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:Inhibition of activated human coagulation factor 11 using pyroGlu-Pro-Arg-pNA as substrate incubated for 10 to 120 mins by spectrofluorometric methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKi: 0.310nM Kon: 0.00000207M-1s-1 Koff: 6.63E+3s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.310nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptors in guine pig brain (minus cerebellum).More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.330nMAssay Description:Displacement of [3H]-U-69,593 from kappa opioid receptors in guine pig brain (minus cerebellum).More data for this Ligand-Target Pair
Affinity DataKi: 0.330nM ΔG°: -53.6kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were determined ...More data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.5 containing 0.1-0.2 M sodium chloride and 0.5% PEG 8000. De...More data for this Ligand-Target Pair
Affinity DataKi: 0.370nM ΔG°: -53.3kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.390nMAssay Description:Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.430nMAssay Description:Receptor binding affinity towards opioid receptor kappaMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.5 containing 0.1-0.2 M sodium chloride and 0.5% PEG 8000. De...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.470nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.480nMAssay Description:Compound was evaluated for its binding affinity against Opioid receptor kappa 1 subtype in guinea pig brain (minus cerebellum)using [3H]-U-69,593 as ...More data for this Ligand-Target Pair
Affinity DataKi: 0.490nMAssay Description:Receptor binding affinity towards opioid receptor muMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibition of human factor11a using pyro-Glu-Pro-Arg-pNA(para-nitroaniline) substrate by spectrophotometryMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity against Opioid receptor kappa 1 of guinea pig using [3H]-U-65,693 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity against Opioid receptor delta 1 using [3H][D-Ala2, D-Leu5]-enkephalin as radioligandMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Charles River Discovery Research Services
Curated by ChEMBL
Charles River Discovery Research Services
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]-Ro15-1788 from human GABAA alpha5beta3gamma2 by scintillation proximity assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.510nMAssay Description:Displacement of [3H]-BRL 52537 from opioid receptor kappa site in guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 0.510nM ΔG°: -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
Affinity DataKi: 0.520nMAssay Description:Plasma kallikrein determinations were made in 0.1 M sodium phosphate buffer at a pH of 7.5 containing 0.1-0.2 M sodium chloride and 0.5% PEG 8000. De...More data for this Ligand-Target Pair
Affinity DataKi: 0.520nM ΔG°: -52.5kJ/molepH: 7.0 T: 2°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.530nMAssay Description:Compound was evaluated for its binding affinity against Opioid receptor kappa 1 subtype in guinea pig brain (minus cerebellum) .using [3H]-U-69,593 a...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Zambeletti Research Laboratories
Curated by ChEMBL
Zambeletti Research Laboratories
Curated by ChEMBL
Affinity DataKi: 0.560nMAssay Description:Binding affinity against Opioid receptor kappa 1 of guinea pig using [3H]-U-65,693 as radioligandMore data for this Ligand-Target Pair