TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 0.000340nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 0.0100nMAssay Description:Inhibition of DHFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Inhibition of thymidin synthaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
Affinity DataKi: 3nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 4.10nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.10nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 8.5nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Mixed inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Universita` Degli Studi Di Sassari
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of human DHFR using dihydrofolate as substrate after 180 secs by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Inhibitory constant against human thymidylate synthaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of human thymidylate synthase expressed in Escherichia coli incubated for 1 hr by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibitory constant against thymidylate synthase from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataKi: 18nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataKi: 29nMAssay Description:Competitive inhibition of human FolD dehydrogenase activityMore data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Non-competitive inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Institute Of Theoretical Studies Ggmbh
Curated by ChEMBL
Affinity DataKi: 30nM ΔG°: -42.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
Affinity DataKi: 31nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute
Curated by ChEMBL
Sanford Burnham Prebys Medical Discovery Institute
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human STK4 (43 to 431 residues) expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 35nMAssay Description:Non-competitive inhibition of human erythrocytes AchE using acetylthiocholine iodide as substrate incubated for 20 mins by Lineweaver-Burk plot analy...More data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataKi: 45nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute
Curated by ChEMBL
Sanford Burnham Prebys Medical Discovery Institute
Curated by ChEMBL
Affinity DataKi: 50nMAssay Description:Binding affinity to recombinant N-terminal His6-tagged human STK4 (43 to 431 residues) expressed in Escherichia coli assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 52nMAssay Description:Inhibition of recombinant Escherichia coli LeuRS assessed as inhibition of 14C-radiolabelled leucine transfer to tRNA leucine preincubated for 10 min...More data for this Ligand-Target Pair