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Found 164 with Last Name = 'diefenbacher' and Initial = 'cg'
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291559(CHEMBL268473 | {2-Benzo[1,3]dioxol-5-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291555(CHEMBL276690 | {2-Benzo[1,3]dioxol-4-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034841((S)-5-Biphenyl-4-yl-4-(2-carboxy-ethylcarbamoyl)-p...)
Affinity DataIC50:  0.700nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  0.740nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291558(CHEMBL276872 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  0.810nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017742(CHEMBL316180 | disodium 2-benzyl-4-(3-carboxylatop...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  1.5nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291557(CHEMBL268761 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  1.60nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034851(3-[(S)-3-Biphenyl-4-yl-2-(phosphonomethyl-amino)-p...)
Affinity DataIC50:  2nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017129((S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-y...)
Affinity DataIC50:  2nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038591(6-(5-Chloro-1-methyl-2-pyridin-3-yl-1H-indol-3-yl)...)
Affinity DataIC50:  2nMAssay Description:Tested for 50% inhibition of thromboxane synthase (TxS) in human platelets (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50021153(1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbo...)
Affinity DataIC50:  2nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017736(2-Benzyl-4-(3-carboxy-propionylamino)-5-phenyl-pen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291556(CHEMBL273489 | {2-Benzo[1,3]dioxol-5-yl-1-[(R)-2-b...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50021184(1-(4-Benzyloxycarbonylamino-4-carboxy-butyryl)-oct...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of angiotensin I converting enzyme from rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  3nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038580(CHEMBL55763 | Potassium;2-(1-Carboxymethyl-2-oxo-2...)
Affinity DataIC50:  4nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038593(CHEMBL301130 | Potassium ;2-(1-Carboxymethyl-2-oxo...)
Affinity DataIC50:  4nMAssay Description:Tested for 50% inhibition of thromboxane synthase (TxS) in human platelets (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017755(2-Benzyl-4-(carboxymethyl-carbamoyl)-5-phenyl-pent...)
Affinity DataIC50:  4nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017734(2-Benzyl-4-(2-benzylsulfanyl-1-carboxy-ethylcarbam...)
Affinity DataIC50:  4nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291561(CHEMBL10251 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetraz...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017741(2-Benzyl-4-(1-carboxy-3-phenyl-propylcarbamoyl)-5-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5nMAssay Description:The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034842((2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017733((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against Enkephalinase from rabbit using method 2 is determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  5nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034846((2R,4R)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50:  5.30nMAssay Description:The compound was tested in vitro for inhibition of neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017752(2-Benzyl-4-(2-benzyloxy-1-carboxy-ethylcarbamoyl)-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038594((S)-2-((3S,5R)-5-Acetoxy-1-carboxymethyl-2-oxo-2,3...)
Affinity DataIC50:  6nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038593(CHEMBL301130 | Potassium ;2-(1-Carboxymethyl-2-oxo...)
Affinity DataIC50:  6nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50159369(CGS-31,4447 | CHEMBL415967 | {1-[(S)-2-Biphenyl-4-...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50367235(CHEMBL1169570)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of angiotensin I converting enzyme from rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038598((S)-2-((S)-1-Carboxymethyl-2-oxo-2,3,4,5-tetrahydr...)
Affinity DataIC50:  7nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038596((S)-6-Amino-2-((R)-1-carboxymethyl-2-oxo-2,3,4,5-t...)
Affinity DataIC50:  7nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50021176(1-(4-Benzyloxycarbonylamino-4-carboxy-butyryl)-2,3...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of angiotensin I converting enzyme from rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038583((S)-2-((3S,5R)-1-Carboxymethyl-5-hydroxy-2-oxo-2,3...)
Affinity DataIC50:  8nMAssay Description:Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017733((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...)
Affinity DataIC50:  8nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM21641(2-(2-benzyl-3-sulfanylpropanamido)acetic acid | CH...)
Affinity DataIC50:  8.30nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using ANF(atrial natriuretic factor) as substrateMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291562(CHEMBL9963 | {1-[(R)-2-Biphenyl-4-yl-1-(1H-tetrazo...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetThromboxane-A synthase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50038586(CHEMBL544493 | [4-(3-Methyl-2-pyridin-3-yl-indol-1...)
Affinity DataIC50:  9nMAssay Description:Tested for 50% inhibition of thromboxane synthase (TxS) in human platelets (in vitro)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017743(2-Benzyl-4-(3-carboxy-propionylamino)-5-phenyl-pen...)
Affinity DataIC50:  9nMAssay Description:Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017733((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...)
Affinity DataIC50:  9nMAssay Description:The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50017738(CHEMBL316172 | N-(4-Hydroxy-3-methoxy-benzyl)-2-me...)
Affinity DataIC50:  9nMAssay Description:Inhibition of enkephalinase activity in membranes prepared from rabbitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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