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Found 2335 with Last Name = 'felts' and Initial = 'a'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataKi:  4.40nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50442525(CHEMBL2440659 | US8796295, Table 2: Compound: 1)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor allosteric binding site (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50047700(CHEMBL3314850)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]methoxyPEPy from rat mGlu5 expressed in HEK293A cells after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50605085(CHEMBL5204021)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]-NMS from rat muscarinic M5 receptor stably expressed in CHO cells membrane by topCount scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50323286(3-cyano-5-fluoro-N-m-tolylbenzamide | CHEMBL120920...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50323308(3-cyano-5-fluoro-N-(4-methylthiazol-2-yl)benzamide...)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50311887(6-bromo-N-(3-chlorophenyl)quinazolin-4-amine | CHE...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50258619(3-Cyano-5-fluoro-N-(6-methylpyridin-2-yl)-benzamid...)
Affinity DataKi:  157nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50323289(CHEMBL1209202 | N-(3-chlorophenyl)-3-cyano-5-fluor...)
Affinity DataKi:  206nMAssay Description:Displacement of [3H]methoxy-PEPy from rat mGlu5 receptor expressed in HEK293A cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257064(CHEMBL2386850)
Affinity DataKi:  240nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50311876(CHEMBL1075626 | N-(3-bromophenyl)-6-chloroquinazol...)
Affinity DataKi:  249nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257087(CHEMBL4102569)
Affinity DataKi:  388nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGlu5 receptor expressed in HEK293A cell membranes after 1 hr by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50311858(CHEMBL1076333 | N-(3-bromophenyl)-6-fluoroquinazol...)
Affinity DataKi:  736nMAssay Description:Displacement of [3H]3methoxy-5-(pyridin-2-ylethynyl)pyridine from rat mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrateMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50426242(CHEMBL2312346)
Affinity DataKi:  2.24E+3nMAssay Description:Displacement of [3H]-NMS from human muscarinic M5 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50491628(CHEMBL2386352)
Affinity DataKi:  1.30E+4nMAssay Description:Binding affinity to wild type human COX2 expressed in insect cells using [1-14C]-arachidonic acid as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50426242(CHEMBL2312346)
Affinity DataKi:  2.53E+4nMAssay Description:Displacement of [3H]-NMS from human muscarinic M1 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50426242(CHEMBL2312346)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50426242(CHEMBL2312346)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-NMS from human muscarinic M3 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50426242(CHEMBL2312346)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-NMS from human muscarinic M4 receptor expressed in CHO cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  0.710nMAssay Description:Displacement of [125I]RTI-55 from recombinant human DAT expressed in CHOK1 cells after 3 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560457(CHEMBL4790396)
Affinity DataIC50:  1nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50605085(CHEMBL5204021)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at rat muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50447893(CHEMBL3114792)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257058(CHEMBL2386849)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using (R)-bufuralol as substrate preincubated for 15 mins measured after 8 mins in presence or absence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257058(CHEMBL2386849)
Affinity DataIC50:  3.10nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257041(CHEMBL4077672)
Affinity DataIC50:  3.5nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257041(CHEMBL4077672)
Affinity DataIC50:  3.60nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50447910(CHEMBL3114969)
Affinity DataIC50:  4nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560479(CHEMBL4778971)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560466(CHEMBL4740381)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560468(CHEMBL4786529)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560477(CHEMBL4742906)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560479(CHEMBL4778971)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560477(CHEMBL4742906)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560478(CHEMBL4790557)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560467(CHEMBL4788859)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK3 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560480(CHEMBL4779300)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560481(CHEMBL4746124)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560477(CHEMBL4742906)
Affinity DataIC50: <5nMAssay Description:Inhibition of human ALK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50447890(CHEMBL3114971)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560482(CHEMBL4753476)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50560472(CHEMBL4741939)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human ALK2 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50:  6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50:  6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM128279(US8796295, Table 2: Compound: 3)
Affinity DataIC50:  6.90nMAssay Description:The utility of the compounds in accordance with the present invention as negative allosteric modulators of metabotropic glutamate receptor activity, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257080(CHEMBL4096818)
Affinity DataIC50:  7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257080(CHEMBL4096818)
Affinity DataIC50:  7.20nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50457526(CHEMBL4213773)
Affinity DataIC50:  8nMAssay Description:Negative allosteric modulator activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of EC80 glutamate-induced Ca2+ mobiliz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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