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Found 418 with Last Name = 'ferrari' and Initial = 'v'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
TargetBifunctional glutamate/proline--tRNA ligase(Homo sapiens (Human))TBA
LigandPNGBDBM50614449(CHEMBL1163086)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human Prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50322367(5-(4-(pyrrolidin-1-ylmethyl)phenyl)-2,3,4,6-tetrah...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProline--tRNA ligase(Escherichia coli (strain K12))TBA
LigandPNGBDBM50614449(CHEMBL1163086)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to Escherichia coli K12 Prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50154730(6-(4-((dimethylamino)methyl)phenyl)-3,4-dihydro-[1...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50401014(CHEMBL2206307)
Affinity DataKi:  8nMAssay Description:Binding affinity to DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataKi:  9nMAssay Description:Competitive inhibition of full length recombinant human GSK-3alpha expressed in baculovirus infected insect Sf9 cells using GS-2 peptide as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional glutamate/proline--tRNA ligase(Homo sapiens (Human))TBA
LigandPNGBDBM50614450(CHEMBL5279127)
Affinity DataKi:  85nMAssay Description:Binding affinity to human Prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAdenosine kinase(Homo sapiens (Human))TBA
LigandPNGBDBM50614446(CHEMBL5283680)
Affinity DataKi:  232nMAssay Description:Binding affinity to ADK (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamine--tRNA ligase(Escherichia coli)TBA
LigandPNGBDBM50614451(CHEMBL5291357)
Affinity DataKi:  280nMAssay Description:Binding affinity to Escherichia coli K12 glutaminyl-tRNA synthetase assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProline--tRNA ligase(Escherichia coli (strain K12))TBA
LigandPNGBDBM50614450(CHEMBL5279127)
Affinity DataKi:  490nMAssay Description:Binding affinity to Escherichia coli K12 Prolyl-tRNA synthetaseMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))TBA
LigandPNGBDBM50614428(CHEMBL5283919)
Affinity DataKi:  690nMAssay Description:Binding affinity to human HGPRT assessed as inhibition of constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM108460(CHEMBL2178393 | US11191732, Example 1 | US8604016,...)
Affinity DataKi:  2.00E+3nMAssay Description:Uncompetitive inhibition of human kidney glutaminase (124 to 669) assessed as reduction of glutamine hydrolysis by double-reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Sus scrofa (pig))
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  2.10E+4nMAssay Description:Competitive inhibition of pig kidney DAAO using D-Alanine as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50304738(2-(3-((S)-1-carboxy-3-methylbutyl)ureido)pentanedi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50503760(CHEMBL4442450)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM27525(N-[3-(morpholin-4-yl)propyl]-8-oxo-9-azatetracyclo...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  1.93nMAssay Description:Displacement of [3H]WIN35,428 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392040(CHEMBL2152556)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392045(CHEMBL2152561)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50296249((1R,2S,3S,5S)-methyl 8-(4-fluorobut-2-ynyl)-3-p-to...)
Affinity DataIC50:  3.26nMAssay Description:Displacement of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50322367(5-(4-(pyrrolidin-1-ylmethyl)phenyl)-2,3,4,6-tetrah...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392046(CHEMBL2152562)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM27721(3-(4-cyanophenyl)quinoxaline-5-carboxamide | CHEMB...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50220858((S)-8-chloro-2-(3-(4-phenylpiperidin-1-yl)cyclopen...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50503756(CHEMBL4473741)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50068775(2H-Isoquinolin-1-one | CHEMBL339695 | isoquinolin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50416360(CHEMBL1171298)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50416361(CHEMBL1171304)
Affinity DataIC50:  9.93nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50101114(8-Fluoro-6-oxo-5,6-dihydro-phenanthridine-3-sulfon...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against purified recombinant human Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Escherichia coli (strain K12))TBA
LigandPNGBDBM50614445(CHEMBL5282738)
Affinity DataIC50:  10nMAssay Description:Inhibition of MraY in Escherichia coliMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50614431(CHEMBL5289236)
Affinity DataIC50:  12nMAssay Description:Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as microbial growth inhibitionMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM27708(8-chloro-2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahyd...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50101129(8-Fluoro-6-oxo-5,6-dihydro-phenanthridine-3-carbox...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration against purified recombinant human Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine--tRNA ligase(Escherichia coli (strain K12))TBA
LigandPNGBDBM50614447(CHEMBL5287030)
Affinity DataIC50:  14nMAssay Description:Inhibition of Escherichia coli K12 methionyl tRNA synthetaseMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50101129(8-Fluoro-6-oxo-5,6-dihydro-phenanthridine-3-carbox...)
Affinity DataIC50:  14nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM17762(3-[2-carboxy-2-(3-sulfanylpropyl)ethyl]benzoic aci...)
Affinity DataIC50:  15nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50503754(CHEMBL4458733)
Affinity DataIC50:  16nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50392041(CHEMBL2152557)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospho-N-acetylmuramoyl-pentapeptide-transferase(Staphylococcus aureus (strain MRSA252))TBA
LigandPNGBDBM50614429(CHEMBL5265940)
Affinity DataIC50:  17nMAssay Description:Inhibition of Staphylococcus aureus MraYMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50503757(CHEMBL4541841)
Affinity DataIC50:  17nMAssay Description:Inhibition of N-terminally tagged human recombinant GCP2 (44 to 750 residues) extracellular domain expressed in Drosophila melanogaster S2 cells prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50120267(3-(2,4-Dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM27497(2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Johns Hopkins University Brain Science Institute

Curated by ChEMBL
LigandPNGBDBM50101124(CHEMBL298053 | sodium 8-fluoro-6-oxo-5,6-dihydroph...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against purified recombinant human Poly (ADP-ribose) polymerase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332228(1-(3-Carboxyphenyl)-3-(2-mercapto-ethyl)-1H-indole...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332218(1-[(3-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1H...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50614433(CHEMBL5272467)
Affinity DataIC50:  22nMAssay Description:Inhibition of Bacillus subtilis MraYMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332217(1-[(2-carboxyphenyl)methyl]-3-(2-mercaptoethyl)-1H...)
Affinity DataIC50:  22nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50332228(1-(3-Carboxyphenyl)-3-(2-mercapto-ethyl)-1H-indole...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant GCP2 using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrate by microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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