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Found 164 with Last Name = 'fine' and Initial = 'rm'
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25082(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Affinity DataIC50:  39.9nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Affinity DataIC50:  83nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25095(4-(2,4-diaminopteridin-6-yl)benzene-1,2-diol | dia...)
Affinity DataIC50:  195nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Affinity DataIC50:  235nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25094(4-[2,4-diamino-7-(3,4-dihydroxyphenyl)pteridin-6-y...)
Affinity DataIC50:  273nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332304((5-amino-3-(pyridin-3-ylamino)-1H-1,2,4-triazol-1-...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  610nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332298(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332299(CHEMBL1287940 | methyl 4-(5-amino-1-(2,6-difluorob...)
Affinity DataIC50:  760nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25106(4-[4-amino-6-(3,4-dihydroxyphenyl)pteridin-7-yl]be...)
Affinity DataIC50:  968nMAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(CHEMBL1287812 | ethyl 3-(5-amino-1-(2,6-difluorobe...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human recombinant JAK1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25096(4-(2,4-diaminopteridin-6-yl)phenol | diaminopterid...)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25112(4-(4-aminopteridin-6-yl)benzene-1,2-diol | aminopt...)
Affinity DataIC50:  1.30E+3nMAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25084(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Affinity DataIC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332297(CHEMBL1287812 | ethyl 3-(5-amino-1-(2,6-difluorobe...)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of human recombinant TYK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332300(4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332296(3-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazo...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332303((5-amino-3-(4-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25097(4-[2,4-diamino-7-(4-hydroxyphenyl)pteridin-6-yl]ph...)
Affinity DataIC50:  2.70E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25098(3-(2,4-diaminopteridin-7-yl)phenol | diaminopterid...)
Affinity DataIC50:  3.00E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332301((5-amino-3-(phenylamino)-1H-1,2,4-triazol-1-yl)(2,...)
Affinity DataIC50:  3.25E+3nMAssay Description:Inhibition of human recombinant JAK3 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25091(3-[4-amino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol...)
Affinity DataIC50:  4.00E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25110(4-[4-amino-6-(4-hydroxyphenyl)pteridin-7-yl]phenol...)
Affinity DataIC50:  4.00E+3nMAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25099(4-(2,4-diaminopteridin-7-yl)phenol | diaminopterid...)
Affinity DataIC50:  4.70E+3nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50332302((5-amino-3-(3-(dimethylamino)phenylamino)-1H-1,2,4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant JAK2 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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