Affinity DataKi: 1.90nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Displacement of [3H]-JNJ962 from BACE1 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:Displacement of [3H]-JNJ-962 from BACE1 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 479nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 1.09E+3nMAssay Description:Displacement of [3H]-JNJ962 from BACE2 (unknown origin) expressed in HEK293 cell membrane assessed as inhibition constant by scintillation counting a...More data for this Ligand-Target Pair
Affinity DataKi: 1.74E+3nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1A4(Rattus norvegicus)
Tohoku University School Of Medicine
Curated by ChEMBL
Tohoku University School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.80E+3nMAssay Description:TP_TRANSPORTER: inhibition of Digoxin uptake in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Displacement of [3H]-JNJ-962 from BACE2 (unknown origin) expressed in HEK293 cell membranes by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.0530nMAssay Description:Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
Affinity DataIC50: 0.110nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.177nMAssay Description:Inhibition of human MMP-9 by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ACE (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.210nMAssay Description:Inhibition of canine lung PDE5 using [3H]cGMP incubated for 30 mins by scintillation analysisMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.220nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.230nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.290nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:A reaction was performed on a 384-well plate (Greiner Bio One) using a reaction volume of 24 µL, and all the samples were diluted with an assay buffe...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.310nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.380nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
Affinity DataIC50: 0.380nMAssay Description:Inhibition of BACE1 in human SH-SY5Y cells expressing human wild type amyloid precursor protein assessed as reduction in amyloidbeta40 production inc...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.380nMAssay Description:Inhibition of canine lung PDE5 using [3H]cGMP substrate by radiolabeled nucleotide methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Very late antigen-4 (VLA-4) expressing human leukemia cells (HL-60) aggregation with human Vascular cell adhesion molecule-1 (VCAM-1) e...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.422nMAssay Description:Inhibition of human MMP-2 by fluorometric assayMore data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Pharmaceutical Research Institute
Curated by ChEMBL
Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to integrin alphavbeta3 receptor (unknown origin) in presence of fibrinogen incubated for 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Canis lupus familiaris)
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Mitsubishi Tanabe Pharma
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair