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Found 181 with Last Name = 'gleason' and Initial = 'jl'
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataIC50:  13nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320744(CHEMBL1164227 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  14nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320746(CHEMBL1165164 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  15nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  23nMAssay Description:Inhibition of purified human HDAC1 using Ac-Leu-Gly-(e-Ac)Lys-AMC by fluorometric HDAC assayMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320745(CHEMBL1165082 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  29nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50175297(CHEMBL3810245)
Affinity DataIC50:  31nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
The Royal Institution For The Advancement of Learning/Mcgill University

US Patent
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33.8nMpH: 8.1 T: 2°CAssay Description:Boc-Lys(Ac)-7-amino-4-methylcoumarin (Boc-Lys(Ac)-AMC) was used as substrate for the HDAC assays. Substrate solution was prepared as follow: Boc(Lys-...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320738(CHEMBL1164212 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  36nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  60nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50276802(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at recombinant human ERalpha expressed in HEK293 cells assessed as inhibition of estradiol-induced YFP-fused SRC1 coactivator rec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320735(CHEMBL1164992 | triciferol)
Affinity DataIC50:  87nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50329614((6R)-N-(2-aminophenyl)-6-((1R,7aR)-4-(2-((3R,5S)-3...)
Affinity DataIC50:  107nMAssay Description:Binding affinity to VDR-LBD by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human full length C-terminal His-tagged HDAC3/N-terminal GST-tagged human NCOR2 (395 to 489 residues) expressed in baculovirus expressi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50175302(CHEMBL3808401)
Affinity DataIC50:  150nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
The Royal Institution For The Advancement of Learning/Mcgill University

US Patent
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC3 after 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 3(Homo sapiens (Human))
The Royal Institution For The Advancement of Learning/Mcgill University

US Patent
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 2C8(Homo sapiens (Human))
Boehringer Ingelheim (Canada)

Curated by ChEMBL
LigandPNGBDBM50175303(CHEMBL3810042)
Affinity DataIC50:  180nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499401(CHEMBL3735770)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at ERalpha in human T47D-KBLuc cells assessed as inhibition of E2-induced transcriptional activity by luciferase reporter gene as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320737((R)-N-(2-Aminophenyl)-6-((1R,3aS,7aR,E)-4-(2-((3R,...)
Affinity DataIC50:  185nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50599546(CHEMBL5170796)
Affinity DataIC50:  190nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320748(CHEMBL1164243 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  196nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499398(CHEMBL3735995)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  210nMAssay Description:Inhibition of HDAC2 after 10 mins by fluorometric assayMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320742(CHEMBL1164225 | N-((R)-4-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  213nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320737((R)-N-(2-Aminophenyl)-6-((1R,3aS,7aR,E)-4-(2-((3R,...)
Affinity DataIC50:  248nMAssay Description:Binding affinity to VDR-LBD by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320736((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-Dihydroxyc...)
Affinity DataIC50:  248nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50599545(CHEMBL5176010)
Affinity DataIC50:  280nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320747(CHEMBL1164241 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  280nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50463468(CHEMBL4237922)
Affinity DataIC50:  300nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
The Royal Institution For The Advancement of Learning/Mcgill University

US Patent
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  310nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320743(CHEMBL1164226 | N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R...)
Affinity DataIC50:  321nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  340nMAssay Description:Inhibition of purified human HDAC1 using Ac-Leu-Gly-(e-Ac)Lys-AMC by fluorometric HDAC assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50471252(CHEMBL1222035 | ICI-164384)
Affinity DataIC50:  340nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  350nMAssay Description:Inhibition of HDAC6 after 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM18678((2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-f...)
Affinity DataIC50:  350nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50599533(CHEMBL5204177)
Affinity DataIC50:  390nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50599536(CHEMBL5173941)
Affinity DataIC50:  390nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataIC50:  450nMAssay Description:Anti-androgenic activity at androgen receptor (unknown origin) expressed in HEK293 cells by BRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50463466(CHEMBL4240593)
Affinity DataIC50:  484nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50499400(CHEMBL3735106)
Affinity DataIC50:  510nMAssay Description:Antagonist activity at luciferase-fused ERalpha in human HEK293 cells expressing eYFP assessed as reduction of E2-induced estrogenic activity after 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50463465(CHEMBL4248952)
Affinity DataIC50:  519nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in Sf9 cells using Ac-Leu-Gly-Lys(Ac)-AMC as substrate measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320741((R)-N-(2-Aminophenyl)-5-((1R,3aS,7aR,E)-4-(2-((3R,...)
Affinity DataIC50:  524nMAssay Description:Binding affinity to VDR ligand binding domain by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM242915(US9428447, DK-406)
Affinity DataIC50:  557nMpH: 8.1 T: 2°CAssay Description:Boc-Lys(Ac)-7-amino-4-methylcoumarin (Boc-Lys(Ac)-AMC) was used as substrate for the HDAC assays. Substrate solution was prepared as follow: Boc(Lys-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  580nMpH: 8.1 T: 2°CAssay Description:Boc-Lys(Ac)-7-amino-4-methylcoumarin (Boc-Lys(Ac)-AMC) was used as substrate for the HDAC assays. Substrate solution was prepared as follow: Boc(Lys-...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetHistone deacetylase 6(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50320735(CHEMBL1164992 | triciferol)
Affinity DataIC50:  580nMAssay Description:Inhibition of HDAC6 after 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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