Affinity DataKi: 3.80nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Binding affinity to human CB1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
Affinity DataKi: 41nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 41nM ΔG°: -43.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 61nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenaseMore data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 163nMAssay Description:Inhibition of tetra-acetylated Histone H4 peptide binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after...More data for this Ligand-Target Pair
Affinity DataKi: 190nM ΔG°: -39.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 200nM ΔG°: -39.8kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain1 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 260nM ΔG°: -39.1kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 260nM ΔG°: -39.1kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 312nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
Affinity DataKi: 385nMAssay Description:Inhibition of Cy5-linked JQ1 probe binding to recombinant human N-terminal TEV-cleavable hexa-histidine tagged BRD4 bromodomain2 after 60 mins by HTR...More data for this Ligand-Target Pair
Affinity DataKi: 420nM ΔG°: -37.9kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 1.49E+3nM ΔG°: -34.6kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 3.40E+3nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
Affinity DataKi: 1.09E+4nM ΔG°: -29.5kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataKi: 3.40E+4nMAssay Description:Inhibition of human recombinant IDO using L-tryptophan as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 6.20E+4nM ΔG°: -25.0kJ/molepH: 6.5 T: 2°CAssay Description:The ability of the compounds prepared in this study to inhibit purified recombinant human IDO was evaluated with a steady state spectrophotometric as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0200nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes
Curated by ChEMBL
Taiwan National Health Research Institutes
Curated by ChEMBL
Affinity DataIC50: 0.370nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.671nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.726nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 0.733nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataIC50: 0.940nMAssay Description:Inhibition of human ALK6 using casein as substrate in presence of 10 uM ATP by radiometric kinase assayMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FLT4 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Amri
Curated by ChEMBL
Amri
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of glycine transporter-1B in human JAR cells assessed as reduction in [14C]glycine uptake preincubated for 10 mins followed by [14C]glycin...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK peptide as substrate in presence of [gamma-33P]-ATP by scintillation counting methodMore data for this Ligand-Target Pair