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Found 157 with Last Name = 'lala' and Initial = 'ds'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382322(CHEMBL2024689)
Affinity DataIC50:  1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156246(US9018391, 8)
Affinity DataIC50:  1.90nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50:  2nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150700(US8981112, 7 | US9526727, 7 | US9949975, Example 7)
Affinity DataIC50:  2nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156243(US9018391, 5)
Affinity DataIC50:  2.60nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156242(US9018391, 4)
Affinity DataIC50:  2.70nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156241(US9018391, 3)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382320(CHEMBL2024687)
Affinity DataIC50:  3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150705(US8981112, 12 | US9526727, 12 | US9949975, Example...)
Affinity DataIC50:  3nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156245(US9018391, 7)
Affinity DataIC50:  3.40nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382319(CHEMBL2024686)
Affinity DataIC50:  4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150704(US8981112, 11 | US9526727, 11 | US9949975, Example...)
Affinity DataIC50:  4nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156252(US9018391, 14)
Affinity DataIC50:  4.5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150697(US8981112, 4 | US9526727, 4)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50:  5nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM389136(US9949975, Example 4)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150701(US8981112, 8 | US9526727, 8 | US9949975, Example 8)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150707(US8981112, 14 | US9526727, 14 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150714(US8981112, 21 | US9526727, 21 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150717(US8981112, 24 | US9526727, 24 | US9949975, Example...)
Affinity DataIC50:  5nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50:  6nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50:  6nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150712(US8981112, 19 | US9526727, 19 | US9949975, Example...)
Affinity DataIC50:  6nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150720(US8981112, 27 | US9526727, 27 | US9949975, Example...)
Affinity DataIC50:  6nMAssay Description:Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156244(US9018391, 6)
Affinity DataIC50:  6.30nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM156250(US9018391, 12)
Affinity DataIC50:  6.80nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150695(US8981112, 2 | US9526727, 2 | US9949975, Example 2)
Affinity DataIC50:  8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150698(US8981112, 5)
Affinity DataIC50:  8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM150715(US8981112, 22 | US9526727, 22 | US9949975, Example...)
Affinity DataIC50:  8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM150695(US8981112, 2 | US9526727, 2 | US9949975, Example 2)
Affinity DataIC50:  8nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
In DepthDetails US Patent
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