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Found 79 with Last Name = 'mead' and Initial = 't'
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  10.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  11.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  1.05E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  1.29E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  1.62E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  2.82E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  6.31E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi:  6.31E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50167898(CHEMBL85606 | N-((1r,4r)-4-(2-(6-cyano-3,4-dihydro...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProgesterone receptor(Homo sapiens (Human))
Northwestern University

LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  1.60nMT: 2°CAssay Description:Competitive binding assay were performed using increasing dose of the contrast agents and fluorescently labeled progesterone as the competitor. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Northwestern University

LigandPNGBDBM68290(RU486)
Affinity DataIC50:  22nMT: 2°CAssay Description:Competitive binding assay were performed using increasing dose of the contrast agents and fluorescently labeled progesterone as the competitor. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446472(CHEMBL3110021 | US9765054, Compound 41B)
Affinity DataIC50:  60nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Mus musculus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Northwestern University

LigandPNGBDBM68291(Steroid-Gd (III) conjugate, 1)
Affinity DataIC50:  96nMT: 2°CAssay Description:Competitive binding assay were performed using increasing dose of the contrast agents and fluorescently labeled progesterone as the competitor. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50245989(1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446472(CHEMBL3110021 | US9765054, Compound 41B)
Affinity DataIC50:  400nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Northwestern University

LigandPNGBDBM68288(Steroid-Gd (III) conjugate, 2)
Affinity DataIC50:  460nMT: 2°CAssay Description:Competitive binding assay were performed using increasing dose of the contrast agents and fluorescently labeled progesterone as the competitor. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50409213(CHEMBL2113347)
Affinity DataIC50:  800nMAssay Description:Inhibition of cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Northwestern University

LigandPNGBDBM68289(Steroid-Gd (III) conjugate, 3)
Affinity DataIC50:  860nMT: 2°CAssay Description:Competitive binding assay were performed using increasing dose of the contrast agents and fluorescently labeled progesterone as the competitor. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263562(1-(2-chlorophenylsulfonyl)-1,5,6,7,8,9-hexahydroaz...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50446472(CHEMBL3110021 | US9765054, Compound 41B)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263563(1-(3-chlorophenylsulfonyl)-1,5,6,7,8,9-hexahydroaz...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263562(1-(2-chlorophenylsulfonyl)-1,5,6,7,8,9-hexahydroaz...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using PPR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50088520(CHEMBL3526575)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of KMO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446474(CHEMBL3109980 | US9765054, Compound 25e)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263563(1-(3-chlorophenylsulfonyl)-1,5,6,7,8,9-hexahydroaz...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using PPR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50088520(CHEMBL3526575)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263617(1-methyl-3-(phenylsulfonyl)-1,5,6,7,8,9-hexahydroa...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446475(CHEMBL3110001)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446479(CHEMBL3110015 | US9765054, Compound 50A)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263566(1-(thiophen-3-ylsulfonyl)-1,5,6,7,8,9-hexahydroaze...)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50088519(CHEMBL3526743)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Homo sapiens (Human))
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50088520(CHEMBL3526575)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Rattus norvegicus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50088518(CHEMBL3526576)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynurenine 3-monooxygenase(Mus musculus)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50061916(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of C57BL/6J mouse KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263518(1-(phenylsulfonyl)-1,5,6,7,8,9-hexahydroazepino[4,...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Biofocus

Curated by ChEMBL
LigandPNGBDBM50446472(CHEMBL3110021 | US9765054, Compound 41B)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263615(3-chloro-1-(3-chlorophenylsulfonyl)-1,5,6,7,8,9-he...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263614(3-chloro-1-(phenylsulfonyl)-1,5,6,7,8,9-hexahydroa...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263617(1-methyl-3-(phenylsulfonyl)-1,5,6,7,8,9-hexahydroa...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using PPR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263616(1-(3-chlorophenylsulfonyl)-7-methyl-1,5,6,7,8,9-he...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of human CYP3A4 by microtiter plate assays using N-N,diethyl-formamide as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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