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Found 618 with Last Name = 'olsen' and Initial = 'c'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataKi:  0.150nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147740(1-(1-Cyclooctyl-piperidin-4-yl)-1,3-dihydro-indol-...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147740(1-(1-Cyclooctyl-piperidin-4-yl)-1,3-dihydro-indol-...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50143282((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...)
Affinity DataKi:  1.53nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331016(6-benzyl-3-(pyridin-3-yl)-6-azabicyclo[3.2.2]non-2...)
Affinity DataKi:  1.95nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  2nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as rate constant (k-2) of EI complex using (Ac-Leu-Gly-Lys(Ac)-AMC as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147743(1-(1-Bicyclo[3.3.1]non-9-yl-piperidin-4-yl)-1,3-di...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147735(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  4nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]epibatidine from alpha7 nAChR in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147742(1-[(R)-1-(Decahydro-naphthalen-2-yl)-piperidin-4-y...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434649(CHEMBL2387196)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147750(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-1...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147749(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataKi:  6nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataKi:  6nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434645(CHEMBL2387194)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataKi:  7nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as rate constant (k-2) of EI complex using (Ac-Leu-Gly-Lys(Ac)-AMC as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  7nMAssay Description:Inhibition of human recombinant HDAC2 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147743(1-(1-Bicyclo[3.3.1]non-9-yl-piperidin-4-yl)-1,3-di...)
Affinity DataKi:  7.5nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147743(1-(1-Bicyclo[3.3.1]non-9-yl-piperidin-4-yl)-1,3-di...)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434640(CHEMBL2387188)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  8nMAssay Description:Inhibition of human recombinant HDAC1 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147735(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434648(CHEMBL2387197)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434644(CHEMBL2387191)
Affinity DataKi:  10nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM50331014(9-methyl-3-(pyridin-3-yl)-9-azabicyclo[3.3.1]non-2...)
Affinity DataKi:  10.4nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434646(CHEMBL2387193)
Affinity DataKi:  11nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147750(1-[1-(Decahydro-naphthalen-2-yl)-piperidin-4-yl]-1...)
Affinity DataKi:  11nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Sri International

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  11.1nMAssay Description:Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrsMore data for this Ligand-Target Pair
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  12nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147741(1-[1-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-piperidi...)
Affinity DataKi:  12nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant HDAC3 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone deacetylase 11(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant HDAC11 using [Ac-Leu-Gly-Lys(Ac)-AMC substrate incubated for 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50595205(CHEMBL5195471)
Affinity DataKi:  13nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as inhibition constant (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434647(CHEMBL2387195)
Affinity DataKi:  13nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Technical University Of Denmark

Curated by ChEMBL
LigandPNGBDBM50377384(AZUMAMIDE C)
Affinity DataKi:  14nMAssay Description:Inhibition of GST-tagged recombinant human HDAC3/NcoR1 enzyme using flurogenic Ac-LeuGlyLys (Ac)-AMC as substrate after 15 to 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147749(1-(1-Cyclooctylmethyl-piperidin-4-yl)-1,3-dihydro-...)
Affinity DataKi:  14nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434643(CHEMBL2387189)
Affinity DataKi:  15nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147742(1-[(R)-1-(Decahydro-naphthalen-2-yl)-piperidin-4-y...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147739(1-[1-(6,6-Dimethyl-bicyclo[3.1.1]hept-2-ylmethyl)-...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50147747(1-[1-(Decahydro-naphthalen-1-yl)-piperidin-4-yl]-1...)
Affinity DataKi:  16nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434641(CHEMBL2387199)
Affinity DataKi:  19nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50434639(CHEMBL2387198)
Affinity DataKi:  20nMAssay Description:Displacement of [3H] N/OFQ from human nociceptin receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147748(1-{1-[1-(9H-Fluoren-2-yl)-ethyl]-piperidin-4-yl}-1...)
Affinity DataKi:  20nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147741(1-[1-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-piperidi...)
Affinity DataKi:  21nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Astraea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50409823(CHEMBL2112407)
Affinity DataKi:  22nMAssay Description:Binding affinity against human Nociceptin receptor on CHO cell membranes by [3H]N/OFQ displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147745(1-[1-(4-Isopropyl-cyclohexyl)-piperidin-4-yl]-1,3-...)
Affinity DataKi:  22nMAssay Description:Binding affinity against human Opioid receptor mu 1 on CHO cell membranes was determined by [3H]DAMGO displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Sri International

Curated by ChEMBL
LigandPNGBDBM50147741(1-[1-(1,2,3,4-Tetrahydro-naphthalen-1-yl)-piperidi...)
Affinity DataKi:  22nMAssay Description:Binding affinity against human Opioid receptor kappa 1 on CHO cell membranes by [3H]U-69593 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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