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Found 164 with Last Name = 'rawlings' and Initial = 'ad'
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  0.0800nM ΔG°:  -57.1kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8339(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8338(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.950nM ΔG°:  -51.0kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096383(Benzo[b]thiophene-2-carboxylic acid [(S)-3-methyl-...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096371(4-tert-Butyl-N-[(S)-3-methyl-1-(4-oxo-tetrahydro-f...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096373(Biphenyl-4-carboxylic acid [(S)-3-methyl-1-(4-oxo-...)
Affinity DataKi:  19nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096380(1H-Indole-6-carboxylic acid [(S)-3-methyl-1-(4-oxo...)
Affinity DataKi:  38nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19804((2S)-4-methyl-N-(4-oxooxolan-3-yl)-2-(quinolin-2-y...)
Affinity DataKi:  44nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096366(Benzofuran-2-carboxylic acid [(S)-3-methyl-1-(4-ox...)
Affinity DataKi:  53nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19797(CHEMBL301683 | acyclic alkoxymethyl ketone inhibit...)
Affinity DataKi:  60nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096370(CHEMBL59115 | Naphthalene-2-carboxylic acid [(S)-3...)
Affinity DataKi:  61nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096374(4-Isopropyl-N-[(S)-3-methyl-1-(4-oxo-tetrahydro-fu...)
Affinity DataKi:  64nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19798(3-amidotetrahydrofuran-4-one, 3 | CHEMBL61805 | be...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096391(CHEMBL58567 | N-[(S)-3-Methyl-1-(4-oxo-tetrahydro-...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096389(Benzo[b]thiophene-2-carboxylic acid [(S)-1-(4-oxo-...)
Affinity DataKi:  190nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096368(CHEMBL59170 | Pyridine-2-carboxylic acid [(S)-3-me...)
Affinity DataKi:  420nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8338(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  450nM ΔG°:  -35.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8339(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  540nM ΔG°:  -35.3kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096369(CHEMBL61482 | Thiophene-2-carboxylic acid [(S)-3-m...)
Affinity DataKi:  640nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096381(4-Methanesulfonyl-N-[(S)-3-methyl-1-(4-oxo-tetrahy...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096376(3,4-Difluoro-N-[(S)-3-methyl-1-(4-oxo-tetrahydro-f...)
Affinity DataKi:  820nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096378(CHEMBL61797 | Cyclohexanecarboxylic acid [(S)-3-me...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096384(CHEMBL62042 | N-[(S)-3-Methyl-1-(4-oxo-tetrahydro-...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096382((S)-2-Acetylamino-4-methyl-pentanoic acid (4-oxo-t...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8327(4-(dimethylamino)-N-{5-phenyl-1H-pyrazolo[3,4-c]py...)
Affinity DataKi:  1.70E+3nM ΔG°:  -32.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096367(Benzo[b]thiophene-2-carboxylic acid [(4-oxo-tetrah...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096375((S)-4-[(Benzo[b]thiophene-2-carbonyl)-amino]-4-(4-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096390(Benzo[b]thiophene-2-carboxylic acid [(S)-2-methyl-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096388((S)-2-[(Benzo[b]thiophene-2-carbonyl)-amino]-penta...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096386(Benzo[b]thiophene-2-carboxylic acid [(S)-1-(4-oxo-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096387(Benzo[b]thiophene-2-carboxylic acid [(S)-2-hydroxy...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096385(Benzo[b]thiophene-2-carboxylic acid [(S)-2-imidazo...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096379(Benzo[b]thiophene-2-carboxylic acid [(S)-1-(4-oxo-...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096377(Benzo[b]thiophene-2-carboxylic acid [(S)-5-amino-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096372(Benzo[b]thiophene-2-carboxylic acid [(S)-2-cyclohe...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8349(6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...)
Affinity DataIC50:  0.800nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8359(6-aryl-pyrazolo[3,4-b]pyridine analogue 23 | N-[5-...)
Affinity DataIC50:  1nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8350(6-aryl-pyrazolo[3,4-b]pyridine analogue 14 | N-[5-...)
Affinity DataIC50:  1nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8364(CHEMBL260416 | N-[6-(3-bromo-4-hydroxyphenyl)-1H-p...)
Affinity DataIC50:  2nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8365(N-[6-(3-chloro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]...)
Affinity DataIC50:  2nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8357(6-aryl-pyrazolo[3,4-b]pyridine analogue 21 | CHEMB...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8330(N-{5-phenyl-1H-pyrazolo[3,4-c]pyridazin-3-yl}butan...)
Affinity DataIC50:  4nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8334(5-(4-ethylpiperazin-1-yl)-N-{5-phenyl-1H-pyrazolo[...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8349(6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8348(6-aryl-pyrazolo[3,4-b]pyridine analogue 12 | CHEMB...)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8370(N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]cyclopropan...)
Affinity DataIC50:  5nMAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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