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Found 937 with Last Name = 'shea' and Initial = 'k'
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84868(Swainsonine derivative, 3)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50:  29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84869(Swainsonine derivative, 4)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/mole IC50:  29nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM84867(Swainsonine derivative, 2)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/mole IC50:  30nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-mannosidase 2(Drosophila melanogaster (Fruit fly))
University of Toronto

LigandPNGBDBM50168995((-)-swainsonine | (1S,2R,8R,8aR)-Octahydro-indoliz...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/mole IC50:  37nMpH: 5.75 T: 2°CAssay Description:Inhibition of dGMII was measured at pH 5.75. Determination of the IC50 values (concentrations of inhibitor at which 50% of activity remains) was car...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50234380(CHEMBL245876 | quinolin-8-yl 4-methyl-3-(piperidin...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Homo sapiens (Human))
University Of St. Andrews

Curated by ChEMBL
LigandPNGBDBM50109155(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Affinity DataKi:  100nMAssay Description:Tested for binding affinity of the compound against kynureninase enzyme from humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Rattus norvegicus)
University Of St. Andrews

Curated by ChEMBL
LigandPNGBDBM50109155(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Affinity DataKi:  130nMAssay Description:Tested for binding affinity of the compound against kynureninase enzyme from ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM12915(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Affinity DataKi:  6.00E+3nMAssay Description:Competitive inhibition of DNA-PK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKynureninase(Homo sapiens (Human))
University Of St. Andrews

Curated by ChEMBL
LigandPNGBDBM50109155(2-Amino-4-hydroxy-4-(3-hydroxy-phenyl)-butyric aci...)
Affinity DataKi:  1.00E+4nMAssay Description:Tested for binding affinity of the compound against kynureninase enzyme from bacterial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50326018((1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentakis(phosphonoox...)
Affinity DataKi:  1.90E+4nMAssay Description:Competitive inhibition of Saccharomyces cerevisiae Pho80-Pho85-Pho81-MD catalyzed phosphorylation of Pho4 assessed as increase in substrate concentra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107412(3-(2-{2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153027((S)-3-Pyrimidin-5-yl-9-(5,6,7,8-tetrahydro-[1,8]na...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153031((S)-3-(2-Methyl-pyrimidin-5-yl)-9-(5,6,7,8-tetrahy...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of PI-3K delta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401764(CHEMBL2207564)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401763(CHEMBL2207565)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134777((S)-3-(2,3-Dihydro-benzofuran-6-yl)-3-{2-oxo-3-[3-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153026((S)-3-(2-Methoxy-pyrimidin-5-yl)-9-(5,6,7,8-tetrah...)
Affinity DataIC50:  0.110nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081221(4-{5-[(S)-2-Butyl-4-(3-chloro-phenyl)-5-oxo-pipera...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107410(3-(2,3-Dihydro-benzofuran-6-yl)-3-(2-{2-oxo-3-[2-(...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081212(4-{5-[(S)-2-Butyl-5-oxo-4-(3-trifluoromethyl-pheno...)
Affinity DataIC50: >0.150nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081215(4-{5-[(S)-4-(3-Chloro-phenyl)-2-ethanesulfonylmeth...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153029((S)-3-Quinolin-3-yl-9-(5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153023((S)-3-(2,3-Dihydro-benzofuran-6-yl)-9-(5,6,7,8-tet...)
Affinity DataIC50:  0.210nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134780((S)-3-{2-Oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthy...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107411((S)-3-(2-Oxo-2,3-dihydro-benzooxazol-6-yl)-3-(2-{(...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121151(3-[5-(3-Cyclopropyl-5,6,7,8-tetrahydro-[1,8]naphth...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401766(CHEMBL2207562)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107407(3-(4-Ethoxy-3-fluoro-phenyl)-3-(2-{2-oxo-3-[2-(5,6...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107415(3-Benzo[1,3]dioxol-5-yl-3-(2-{2-oxo-3-[2-(5,6,7,8-...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134776((S)-3-(3-Fluoro-4-methoxy-phenyl)-3-{2-oxo-3-[3-(5...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121147(2-(2,3-Dihydro-benzofuran-6-yl)-3-[methyl-(3-1,2,3...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107397((S)-3-(2-{(S)-2-Oxo-3-[2-(5,6,7,8-tetrahydro-[1,8]...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19502((2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmethane)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134779((S)-3-{3-[3-(7-Hydroxy-5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081217(4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-5-oxo-pi...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human K-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107417(3-(3-Fluoro-4-methoxy-phenyl)-3-(2-{2-oxo-3-[2-(5,...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121153(3-{[5-(3-Cyclopropyl-5,6,7,8-tetrahydro-[1,8]napht...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50319926(2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI-3K beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401814(CHEMBL2207591)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401765(CHEMBL2207563)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153024((S)-3-(2-Isopropyl-pyrimidin-5-yl)-9-(5,6,7,8-tetr...)
Affinity DataIC50:  0.520nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50107413(3-(2-Fluoro-biphenyl-4-yl)-3-(2-{2-oxo-3-[2-(5,6,7...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of high affinity radioligand binding to human alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401835(CHEMBL2207570)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401834(CHEMBL2207571)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153030((S)-3-(6-Methoxy-pyridin-3-yl)-9-(5,6,7,8-tetrahyd...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against alpha v beta-3 receptor using scintillation proximity assay (SPAV3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50401761(CHEMBL2207567)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121148(2-(2,3-Dihydro-benzofuran-6-yl)-3-(3-1,2,3,4,6,7,8...)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of binding to human integrin receptor alpha V beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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