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Found 360 with Last Name = 'svensson' and Initial = 'm'
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496205(CHEMBL3125043)
Affinity DataKi:  53nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease A156T mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM50282653(CHEMBL4163689)
Affinity DataKi:  110nMAssay Description:Noncompetitive inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496205(CHEMBL3125043)
Affinity DataKi:  110nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease D168V mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496204(CHEMBL3125169)
Affinity DataKi:  110nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease A156T mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496204(CHEMBL3125169)
Affinity DataKi:  180nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease D168V mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496205(CHEMBL3125043)
Affinity DataKi:  210nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease R155K mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM50282650(CHEMBL4173207)
Affinity DataKi:  390nMAssay Description:Competitive inhibition of rat brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepacivirus C)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50496204(CHEMBL3125169)
Affinity DataKi:  580nMAssay Description:Inhibition of Hepatitis C virus genotype 1a full length NS3/2K-NS4A protease R155K mutant using Ac-DED(Edans)EEAbupsi[COO]ASK(Dabcyl)-NH2 as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM50282653(CHEMBL4163689)
Affinity DataKi:  3.00E+3nMAssay Description:Mixed-type inhibition of B6CBAF1/J mouse brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Mus musculus (mouse))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM50282650(CHEMBL4173207)
Affinity DataKi:  6.30E+3nMAssay Description:Mixed-type inhibition of B6CBAF1/J mouse brain FAAH using [3H]AEA as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391055(CHEMBL2088399)
Affinity DataIC50:  3.70nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615666((5-isopropyl-1H-pyrazol-3-yl)[(1R,5S,6r)-6-(1H-tet...)
Affinity DataIC50:  4nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608104(US11691968, Example 134)
Affinity DataIC50:  4nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605601(CHEMBL5184138)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605597(CHEMBL5204161)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605598(CHEMBL5188193)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391031(CHEMBL2088393)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615664((5-isopropyl-1H-pyrazol-3-yl)[(1R,5S,6r)-6-(6-meth...)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615641((1-isopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-(1H-te...)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608078(US11691968, Example 62)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615640((1-isopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-([1,2,...)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608102(US11691968, Example 131)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608079(US11691968, Example 63)
Affinity DataIC50:  10nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605555(CHEMBL5173250)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391029(CHEMBL2088391)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605593(CHEMBL5179642)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM210802(US10463663, Example 40 | US11129828, Example 40 | ...)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
University Of Cagliari

Curated by ChEMBL
LigandPNGBDBM26739(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate preincubated for 10 mins at pH 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608107(US11691968, Example 144)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608089((1-cyclopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-meth...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608089((1-cyclopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-meth...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608080(US11691968, Example 65)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608076(US11691968, Example 59)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608074(US11691968, Example 55)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608073((1-cyclopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-(4-o...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608065(US11691968, Example 1 | US20230271952, Example 1 |...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615669((5-cyclopropyl-1H-pyrazol-3-yl)[(1R,5S,6r)-6-methy...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605599(CHEMBL5178413)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605594(CHEMBL5186374)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608085(US11691968, Example 77)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF® technology (Cisbi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615647((1-isopropyl-1H-imidazol-4-yl){(1R,5S,6r)-6-[(4-me...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615642((1R,5S,6r)-N-tert-butyl-3-[1-(propan-2-yl)-1H-imid...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615638((1-isopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-(4,5,5...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM615636((1-isopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-(5-met...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608073((1-cyclopropyl-1H-imidazol-4-yl)[(1R,5S,6r)-6-(4-o...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM608065(US11691968, Example 1 | US20230271952, Example 1 |...)
Affinity DataIC50:  20nMAssay Description:Using 384-well white Greiner784075 (Greiner), representative compounds were characterized for their inhibition of KDM5A using HTRF technology (Cisbio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605592(CHEMBL5179643)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605595(CHEMBL5174518)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605589(CHEMBL5196542)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50391025(CHEMBL2088398)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human recombinant TRPV1 receptor assessed as inhibition of capsaicin-induced calcium uptake by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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