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Found 319 with Last Name = 'vaz' and Initial = 'rj'
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataKi:  0.0700nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50289194((S)-2-[(S)-4-((R)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156461(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156460(3-[4-(3-Aminomethyl-phenyl)-piperidine-1-carbonyl]...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156457(CHEMBL186730 | [4-(5-Aminomethyl-2-fluoro-phenyl)-...)
Affinity DataKi:  4.30nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073850((S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyr...)
Affinity DataKi:  10nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080206(CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxaz...)
Affinity DataKi:  33nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156459(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  59nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156458(3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-...)
Affinity DataKi:  88nMAssay Description:Inhibitory activity against human mast cell tryptase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080206(CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxaz...)
Affinity DataKi:  120nMAssay Description:Tested for inhibitory activity against bovine cathepsin B.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50281462((R)-2-[(6S,7S)-6-((R)-2-Mercapto-3-phenyl-propiony...)
Affinity DataKi:  330nMAssay Description:Compound was tested for inhibition of neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080207(CHEMBL80142 | {1-[((S)-1-Formyl-2-phenyl-ethyl)-hy...)
Affinity DataKi:  400nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080209(CHEMBL78324 | {1-[((S)-1-Formyl-2-phenyl-ethyl)-me...)
Affinity DataKi:  400nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50366611(CHEMBL1794816)
Affinity DataKi:  1.50E+3nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080210(Acetic acid (4S,5S)-4-benzyl-3-(2-benzyloxycarbony...)
Affinity DataKi:  2.00E+3nMAssay Description:Tested for inhibitory activity against calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073851(((1S,4R)-4-Benzyl-1-isopropyl-2,5-dioxo-pentyl)-ca...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50366612(CHEMBL1794817)
Affinity DataKi:  3.20E+3nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Gallus gallus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50073849(((S)-1-Isopropyl-4-methyl-2,5-dioxo-pentyl)-carbam...)
Affinity DataKi:  4.50E+4nMAssay Description:Inhibitory activity against chicken gizzard smooth muscle calpainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM50080208(CHEMBL73869 | [(R)-1-((2R,3S)-3-Benzyl-2-hydroxy-m...)
Affinity DataKi:  5.60E+4nMAssay Description:Tested for inhibitory activity against calpain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417722(CHEMBL1644207)
Affinity DataIC50:  0.0200nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417777(CHEMBL1644214)
Affinity DataIC50:  0.0501nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417721(CHEMBL1644206)
Affinity DataIC50:  0.100nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417747(CHEMBL1644245)
Affinity DataIC50:  0.302nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417759(CHEMBL1644213)
Affinity DataIC50:  0.302nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417764(CHEMBL1644227)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417725(CHEMBL1644211)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417771(CHEMBL1644247)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417773(CHEMBL1644253)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417726(CHEMBL1644212)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417723(CHEMBL1644208)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417728(CHEMBL1644217)
Affinity DataIC50:  0.794nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417763(CHEMBL1644224)
Affinity DataIC50:  0.891nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50189415(CHEMBL3828637)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50506957(CHEMBL4483506)
Affinity DataIC50:  1nMAssay Description:Inhibition of human CK1 epsilon using casein as substrate after 2 hrs in presence of [33P]-ATP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50509567(CHEMBL4455382 | US11213520, Example I-003)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK8/CyclinC (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417778(CHEMBL1644260)
Affinity DataIC50:  2.29nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417754(CHEMBL1644255)
Affinity DataIC50:  2.29nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417774(CHEMBL1644256)
Affinity DataIC50:  2.57nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417767(CHEMBL1644235)
Affinity DataIC50:  2.57nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417719(CHEMBL1644204)
Affinity DataIC50:  2.69nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417768(CHEMBL1644238)
Affinity DataIC50:  2.88nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHematopoietic prostaglandin D synthase(Homo sapiens (Human))
Sanofi Us

Curated by ChEMBL
LigandPNGBDBM50463698(CHEMBL4247050)
Affinity DataIC50:  3nMAssay Description:Inhibition of HPGDS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Sanofi-Aventis

Curated by ChEMBL
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human DHODH by using blue indicator dye DCIPMore data for this Ligand-Target Pair
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417760(CHEMBL1644216)
Affinity DataIC50:  3.63nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417744(CHEMBL1644240)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Sanofi Aventis Us

Curated by ChEMBL
LigandPNGBDBM50417749(CHEMBL1644248)
Affinity DataIC50:  4.47nMAssay Description:Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290703(4-[2-(1-{2-[3-Phenyl-1-(3,4,5-trimethoxy-benzoyl)-...)
Affinity DataIC50:  4.5nMAssay Description:Antagonistic activity against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290742(4-[2-(1-{2-[3-(3,4-Dimethoxy-phenyl)-1-(3,4,5-trim...)
Affinity DataIC50:  4.60nMAssay Description:Antagonistic activity against histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
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