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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
117
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 0.770nM
Assay Description:
Compound was evalated for its in vitro affinity at serotonergic 5-hydroxytryptamine 3 receptor by radioligand binding assay , using [3H]-LY 278584 in...
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1nM
Assay Description:
In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.60nM
Assay Description:
The binding affinity was measured on muscarine M2 receptor using [3H]- N-Me-SCOPOL as radioligand.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.60nM
Assay Description:
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.60nM
Assay Description:
The binding affinity of the compound was measured on imidazoline I2 receptor using [3H]- indazoxan as radioligand.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 2.5nM
Assay Description:
Inhibitory activity against 5-hydroxytryptamine 1D receptor in rat cortical membranes using [3H]5-HT as a radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 2.5nM
Assay Description:
pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 2.80nM
Assay Description:
Displacement of [3H]granisetron from human 5HT3A receptor expressed in HEK293 cells by filter binding assay
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine
Checked by Author
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.20nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor was determined in rat cerebro cortical membranes using [3H]quipazine.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.30nM
Assay Description:
Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.30nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor of neuronal in the afferent rabbit vagus
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.31nM
Assay Description:
Potency at neuronal 5-hydroxytryptamine 3 receptors in the rabbit heart
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.40nM
Assay Description:
Binding affinity to human HT3A receptor
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Institut De Recherches Servier
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.98nM
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 4nM
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 6.20nM
Assay Description:
Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 6.5nM
Assay Description:
Displacement of binding of [3H]-BRL 43694 to 5-hydroxytryptamine 3 receptor in rat cerebral cortex
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 7.60nM
Assay Description:
Compound was evaluated for its ability to displace [3H]quipazine binding to 5-hydroxytryptamine 3 receptor sites in NG 108-15.
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 7.60nM
Assay Description:
Binding affinity against radioligand [3H]quipazine labeled 5-hydroxytryptamine 3 receptor sites in neuroblastoma-glioma (NG108-15) cells.
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: 9.62nM
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5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Institut De Recherches Servier
Curated by
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 12nM
Assay Description:
The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 ...
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5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Institut De Recherches Servier
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: 15nM
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 16nM
Assay Description:
In vitro inhibition of rat liver dihydrofolate reductase.
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5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 16nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells
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5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 16nM
Assay Description:
In vitro binding affinity for the 5-hydroxytryptamine 3 receptor was determined with NG-108-15 mouse neuroblastoma-glioma cells
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Gastrin/cholecystokinin type B receptor
(RAT)
Solvay Duphar
Curated by
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 680nM
Assay Description:
The binding affinity of the compound was measured on cholecystokinin type B receptor using [3H]- CCK-8 as radioligand.
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Sigma non-opioid intracellular receptor 1
(RAT)
Solvay Duphar
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BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: 680nM
Assay Description:
The binding affinity of the compound was measured on sigma receptor using [3H]- (+)-3-PPP as radioligand.
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Target
5-hydroxytryptamine receptor 7
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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5-hydroxytryptamine receptor 4
(RAT)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: >1.00E+3nM
Assay Description:
In vitro affinity at serotonergic 5-hydroxytryptamine 4 receptor by radioligand binding assay using [3H]GR-113808 in rat striatum membranes.
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5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
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BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.00E+3nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
Universidad De Navarra
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Displacement of binding of [3H]5-HT to 5-hydroxytryptamine 1 receptor in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 4
(RAT)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
The binding affinity of the compound was measured on 5-hydroxytryptamine 4 receptor using [3H]- GR-113,808 as radioligand.
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Target
Mu-type opioid receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 2.90E+3nM
Assay Description:
The binding affinity of the compound was measured on mu-opiate receptor using [3H]- naloxone as radioligand.
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Mus musculus)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >3.00E+3nM
Assay Description:
In vitro Binding affinity towards alpha-7 nAChR was determined
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 3.70E+3nM
Assay Description:
The binding affinity of the compound was measured on 5-hydroxytryptamine 1B receptor using [3H]- serotonin as radioligand.
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 5.00E+3nM
Assay Description:
The binding affinity of the compound was measured on 5-hydroxytryptamine 1C receptor using [3H]- serotonin as radioligand.
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 6.38E+3nM
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F/2A/2B/2C/3A/3B/4/5A/5B/6/7
(Rattus norvegicus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes
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3D Structure (crystal)
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Target
Beta-1/Beta-2/Beta-3 adrenergic receptor
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]- GR-65,630 binding to 5-hydroxytryptamine 3 receptor in rat brain cortical membranes
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on muscarine M2 receptor using [3H]- N-Me-SCOPOL as radioligand.
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S
(Rattus norvegicus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on cholecystokinin type A receptor using [3H]- CCK-8 as radioligand.
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S
(Rattus norvegicus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of rat brain
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
The binding affinity was measured on 5-hydroxytryptamine 2 receptor using [3H]- spiperone as radioligand.
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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Target
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]-ketanserin from human 5-HT2A receptor expressed in CHO-K1 cells measured after 1.5 hrs by Microbeta plate reader method
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method
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Target
5-hydroxytryptamine receptor 3A
(GUINEA PIG)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Czech Republic
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
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Target
Nischarin
(Homo sapiens (Human))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on imidazoline I2 receptor using [3H]- indazoxan as radioligand.
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Target
D(1A) dopamine receptor
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on dopamine receptor D1 using [3H]- dopamine as radioligand.
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on dopamine receptor D2 using [3H]- spiperone as radioligand.
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Target
Histamine H1 receptor
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on histamine H1 receptor using [3H]- mepyramine as radioligand.
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Target
Glycine receptor subunit alpha-4
(Mus musculus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on glycine receptor using [3H]- strychnine as radioligand.
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Target
Delta-type opioid receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on delta-opiate receptor using [3H]- dadle as radioligand.
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Target
5-hydroxytryptamine receptor 5B
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on tryptamine receptor using [3H]- tryptamine as radioligand.
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Target
Muscarinic acetylcholine receptor M1
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on muscarine M1 receptor using [3H]- pirenzepine as radioligand.
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Target
Kappa-type opioid receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on kappa-opiate receptor using [3H]- EKC as radioligand.
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Target
Cholecystokinin receptor type A
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on cholecystokinin type A receptor using [3H]- CCK-8 as radioligand.
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on muscarine M3 receptor using [3H]- N-Me-SCOPOL as radioligand.
More data for this Ligand-Target Pair
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Target
Leukotriene B4 receptor 1
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on leukotriene-D4 receptor using [3H]- LTD4 as radioligand.
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Target
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on alpha2-adrenergic receptor using [3H]- clonidine as radioligand.
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Glutamate receptor ionotropic, NMDA 2C
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on NMDA receptor using [3H]- CGS-19,755 as radioligand.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on 5-hydroxytryptamine 1A receptor using [3H]- 8-OH-DPAT as radioligand.
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Target
Thyrotropin-releasing hormone receptor
(Rattus norvegicus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on TRH receptor using [3H]- MeTRH as radioligand.
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Target
D(3) dopamine receptor
(Rattus norvegicus (Rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on dopamine receptor D3 using [3H]- dopamine as radioligand.
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Target
Histamine H3 receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on histamine H3 receptor using [3H]- N-Me-histam as radioligand.
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Target
Interleukin-6 receptor subunit alpha
(Rattus norvegicus)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
The binding affinity of the compound was measured on leukotriene-6 receptor using [3H]- IL-6 as radioligand.
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Target
5-hydroxytryptamine receptor 1D
(RAT)
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Ki: 2.00E+4nM
Assay Description:
The binding affinity of the compound was measured on 5-hydroxytryptamine 1D receptor using [3H]- serotonin as radioligand.
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Target
Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
Ki: 4.60E+4nM
Assay Description:
In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined
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5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 0.0900nM
Assay Description:
Antagonist activity at human 5HT3A receptor expressed in xenopus oocytes assessed as inhibition of 5HT-induced effect by electrophysiological method
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Syntex Discovery Research
Curated by
PDSP K
i
Database
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 0.160nM
Assay Description:
Binding affinity to rat 5HT3A receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 1.40nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 1.54nM
Assay Description:
Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 1.90nM
Assay Description:
Displacement of [3H]Q-ICS-205-930 from 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 1.90nM
Assay Description:
Displacement of [3H]-Q-ICS 205-930 binding to 5-hydroxytryptamine 3 receptor recognition sites in rat brain membranes.
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 6.80nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 7.10nM
Assay Description:
Binding affinity was evaluated in vitro by displacement of [3H]zacopride radioligand from 5-hydroxytryptamine 3 receptor
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of human MATE1-mediated [14]-metformin uptake expressed in HEK293 cells after 1.5 mins by scintillation counting analysis
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5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Universidad Complutense
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 46nM
Assay Description:
Inhibition of [3H]BRL-43694 binding to rat 5-hydroxytryptamine 3 receptor
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 150nM
Assay Description:
Inhibition of human MATE1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
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Target
Multidrug and toxin extrusion protein 1
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 160nM
Assay Description:
Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Multidrug and toxin extrusion protein 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 160nM
Assay Description:
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells up to 500 uM after 1.5 mins by fluorescence assay
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Multidrug and toxin extrusion protein 2
(Homo sapiens (Human))
University Of California
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 300nM
Assay Description:
Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 400nM
Assay Description:
Inhibition of human ERG expressed in HEK cells by patch clamp technique
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM50241365
((R)-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)...)
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IC50: 810nM
Assay Description:
Inhibition of human ERG potassium channel
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 813nM
Assay Description:
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 813nM
Assay Description:
Inhibitory concentration against potassium channel HERG
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 813nM
Assay Description:
Inhibition of human ERG
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Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 813nM
Assay Description:
Inhibition of human Potassium channel HERG expressed in mammalian cells
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Target
Solute carrier family 22 member 2
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Affinity Data
IC50: 890nM
Assay Description:
Inhibition of human OCT2 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
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D(2) dopamine receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.00E+3nM
Assay Description:
Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligand
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D(2) dopamine receptor
(Rattus norvegicus (rat))
Solvay Duphar
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.00E+3nM
Assay Description:
Inhibition of the binding of radioligand [3H]spiperone to dopamine receptor D2 in rat brain synaptic membrane
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Solute carrier family 22 member 2
(Homo sapiens (Human))
University Of California San Francisco
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 1.70E+3nM
Assay Description:
Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
H. Lundbeck
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >2.00E+3nM
Assay Description:
Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation counting
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Multidrug and toxin extrusion protein 2
(Homo sapiens (Human))
University Of California
Curated by
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 6.90E+3nM
Assay Description:
Inhibition of human MATE2-K expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
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Cytochrome P450 3A4
(Homo sapiens (Human))
Amri
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 1.10E+4nM
Assay Description:
Inhibition of human CYP3A4
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Solute carrier family 22 member 3
(Homo sapiens (Human))
University Of California
Curated by
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 1.74E+4nM
Assay Description:
Inhibition of human OCT3-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
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Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 2.04E+4nM
Assay Description:
Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy
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Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 2.50E+4nM
Assay Description:
Inhibition of the response to ACh when coapplied with Nicotinic acetylcholine receptor alpha7
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Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Homo sapiens (Human))
University Of Florida
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 2.70E+4nM
Assay Description:
Antagonism of ACh-evoked responses at human Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes
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Neuronal acetylcholine receptor subunit alpha-4/beta-2
(Homo sapiens (Human))
Astrazeneca
Curated by
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BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: 6.60E+4nM
Assay Description:
Antagonism of ACh-evoked responses at human Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes
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Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.00E+5nM
Assay Description:
Inhibition of human OCT1 expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
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ATP-binding cassette sub-family C member 3
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...
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Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...
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ATP-binding cassette sub-family C member 2
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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ATP-binding cassette sub-family C member 4
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.33E+5nM
Assay Description:
Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...
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Bile salt export pump
(Homo sapiens (Human))
Amgen
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >1.35E+5nM
Assay Description:
Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...
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Solute carrier family 22 member 1
(Homo sapiens (Human))
Uppsala University
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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IC50: >3.00E+5nM
Assay Description:
Inhibition of human OCT1-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assay
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5-hydroxytryptamine receptor 3A/3B
(Mus musculus (house mouse))
TBA
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Kd: 20nM
Assay Description:
Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor of isolated guinea pig ileum (GPI)
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5-hydroxytryptamine receptor 3A/3B
(Mus musculus (house mouse))
TBA
Curated by
ChEMBL
Ligand
BDBM85330
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
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Kd: 13nM
Assay Description:
Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heart
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