Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 17 hits in this display
IC50: >83nMAssay Description:Inhibition of SMYD3 (unknown origin) using p53 (361 to 380 residues) and [3H]-SAM as substrate incubated for 90 mins by SPA assayMore data for this Ligand-Target Pair
IC50: 120nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in Escherichia coli BL21 (DE3) using Biotinaminohexanoyl-GSRAHSSHLKSKKGQSTSRH as substrate after 75 mi...More data for this Ligand-Target Pair
IC50: <1.00E+4nMAssay Description:Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysisMore data for this Ligand-Target Pair
Kd: 500nMAssay Description:Binding affinity to full length human SMYD2 (1 to 433 residues) expressed in Escherichia coli strain BL21 (DE3) by ITC analysisMore data for this Ligand-Target Pair