BDBM476932 SARS-CoV-2 3CLpro Inhibitors 2c SARS-CoV-2 3CLpro Inhibitors 2d
BDBM476933 SARS-CoV-2 3CLpro Inhibitors 3c SARS-CoV-2 3CLpro Inhibitors 3d
BDBM476944 SARS-CoV-2 3CLpro Inhibitors 2i SARS-CoV-2 3CLpro Inhibitors 2j
BDBM476945 SARS-CoV-2 3CLpro Inhibitors 3i SARS-CoV-2 3CLpro Inhibitors 3j
SARS-CoV-2 3CLpro Inhibitors 2a SARS-CoV-2 3CLpro Inhibitors 2b BDBM476928
SARS-CoV-2 3CLpro Inhibitors 2k BDBM476948 SARS-CoV-2 3CLpro Inhibitors 2l
SARS-CoV-2 3CLpro Inhibitors 2n BDBM476954 SARS-CoV-2 3CLpro Inhibitors 2o
SARS-CoV-2 3CLpro Inhibitors 3a SARS-CoV-2 3CLpro Inhibitors 3b BDBM476929
SARS-CoV-2 3CLpro Inhibitors 3l BDBM476949 SARS-CoV-2 3CLpro Inhibitors 3k
SARS-CoV-2 3CLpro Inhibitors 3n SARS-CoV-2 3CLpro Inhibitors 3o BDBM476955
- Heiser, U; Ramsbeck, D; Sommer, R; Meyer, A; Hoffmann, T; Boehme, L; Demuth, H Inhibitors US Patent US8486940 (2013)
- Dorn, CP; Zimmerman, M; Yang, SS; Yurewicz, EC; Ashe, BM; Frankshun, R; Jones, H Proteinase inhibitors. I. Inhibitors of elastase. J Med Chem 20: 1464-8 (1977)
- Durham, TB; Marimuthu, J; Wiley, MR Aggrecanase inhibitors US Patent US9206139 (2015)
- Zhang, Z; Wang, X; Huang, S; Jiang, X; Li, L; Zhang, Z; Han, J Apoptosis inhibitors US Patent US11725000 (2023)
- Kurhade, S; Dömling, A Arginase inhibitors US Patent US11845767 (2023)
- Legrand, DM; Furminger, V; Thomson, C; Hughes, OR; Stanley, E Autotaxin inhibitors US Patent US9409895 (2016)
- Johnson, TW; Richardson, PF; Collins, MR; Richter, DT; Burke, BJ; Ninkovic, S; Gajiwala, KS; Linton, MA; Le, PT; Hoffman, JE Axl inhibitors US Patent US9593097 (2017)
- Martin, FM; Mergott, DJ; Owton, WM BACE inhibitors US Patent US9328124 (2016)
- Bellenie, BR; Cheung, KM; Davis, OA; Hoelder, S; Huckvale, R; Collie, G; Meniconi, M; Brennan, A; Lloyd, MG BCL6 INHIBITORS US Patent US20230287003 (2023)
- De Man, AP; Sterrenburg, J; Raaijmakers, HC; Kaptein, A; Oubrie, AA; Rewinkel, JB; Jans, CG; Wijkmans, JC; Barf, TA; Cooper, AB; Kim, RM; Boga, SB; Zhu, HY; Gao, X; Yao, X; Anand, R; Wu, H; Liu, S; Yang, C; Alhassan, A; Wang, J; Yu, Y; Liu, J; Vaccaro, HM BTK Inhibitors US Patent US9718828 (2017)
- Liu, J; Kim, RM; Kozlowski, J; Guiadeen, D; Krikorian, AD; Yu, Y BTK inhibitors US Patent US9834554 (2017)
- Edwards, HJ; Evans, DM; Davie, RL; Rooker, DP; Hewison, SJ Bicyclic inhibitors US Patent US9738641 (2017)
- Bennett, MJ; Betancort, JM; Boloor, A; Kaldor, SW; Stafford, JA; Veal, JM Bromodomain inhibitors US Patent US10807982 (2020)
- Liu, J; Kim, RM; Kozlowski, J; Krikorian, AD; Anand, R Btk inhibitors US Patent US9637486 (2017)
- Du, X; Eksterowicz, J; Fantin, VR; Jackson, EL; Sun, D; Ye, Q; Moore, J; Zavorotinskaya, T CD73 inhibitors US Patent US11377469 (2022)
- Hu, Z; He, H; Zhang, F; Zhong, W; Zhu, X CDK INHIBITORS US Patent US20240033264 (2024)
- Tavares, FX; Strum, JC CDK inhibitors US Patent US10189849 (2019)
- Behenna, DC; Freeman-Cook, KD; Hoffman, RL; Nagata, A; Ninkovic, S; Sutton, SC CDK2 inhibitors US Patent US11718603 (2023)
- Vankayalapati, H; Li, Z; Medley, K; Coffman, K; Yan, D; Bearss, DJ CDK9 INHIBITORS US Patent US20230322792 (2023)
- Hachtel, S; Dedio, J; Pernerstorfer, J; Shimshock, S; Lanter, C CXCR2 inhibitors US Patent US8980938 (2015)
- Bockus, AT; Leung, SF; Earp, DJ; Garcia Dominguez, PS; Spellmeyer, DC; Hernandez, L; Baldomero, MP; Gleason, CE; Walton, BF; Singh, R; Aggen, JB; Dupper, NJ; Shapiro, JA; Kreatsoulas, C; Bambal, RB; Fung, CC; Ramaseshan, M CYCLIN INHIBITORS US Patent US20240218021 (2024)
- Abeywardane, A; Hao, M; Taylor, SJ Chymase inhibitors US Patent US8969348 (2015)
- Kolarevic, A; Yancheva, D; Kocic, G; Smelcerovic, A Deoxyribonuclease inhibitors. Eur J Med Chem 88: 101-11 (2014)
- Ahmad, O; Barvian, KK; Campbell, JE; Dineen, TA; Eno, MS; Fernando, DP; Perola, E; Ribeiro da Silva, VB; Perron, Q EGFR INHIBITORS US Patent US20250236608 (2025)
- CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 (2024)
- POULAIN, RD; GEALAGEAS, R; CAMBERLEIN, V; FLEAU, CT; GUILLAUME, V; BOSC, D; DEPREZ, B; SIEROCKI, P ERAP INHIBITORS US Patent US20240101542 (2024)
- Salituro, LJ; Fulton, J; Jalluri, RK; Vine, LE; Bettendorf, T; Fischer, J; Fell, JB; Chicarelli, MJ; Chatterjee, P; Malinky, CA ERBB2 INHIBITORS US Patent US20250129078 (2025)
- Lipford, K; Falcone, D; Sloman, DL; Witter, DJ ERK inhibitors US Patent US9546168 (2017)
- Marx, MA; Lee, MR; Galemmo, RA; Bobinski, TP EZH2 inhibitors US Patent US10266542 (2019)
- Garneau-Tsodikova, S; Tsodikov, OV; Posey, JE Eis inhibitors US Patent US10208000 (2019)
- Davie, RL; Edwards, HJ; Evans, DM; Hodgson, ST; Mazzacani, A; Stocks, MJ; Baker, TM; Conroy, MR; Smith, AJ; Clark, DE Enzyme inhibitors US Patent US11613527 (2023)
- Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Choi, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R FAK inhibitors US Patent US9012461 (2015)
- Jansen, K; De Meester, I; Heirbaut, L; Cheng, JD; Joossens, J; Augustyns, K; Van Der Veken, P FAP inhibitors US Patent US9346814 (2016)
- Zankel, TC; Isbell, SL; Ko, AA Fucosidase inhibitors US Patent US10308607 (2019)
- Axten, JM; Cheung, M; Demartino, MP; Guan, HA; Hu, Y; Miller, AB; Qin, D; Wu, C; Zhang, Z; Lin, X Furin inhibitors US Patent US11773078 (2023)
- Clemons, WM; Kurosu, M GLYCOSYLTRANSFERASE INHIBITORS US Patent US20240199677 (2024)
- Quattropani, A; Kulkarni, SS; Giri, AG Glycosidase inhibitors US Patent US11046712 (2021)
- Jacques, V; Rusche, JR HDAC inhibitors US Patent US10428028 (2019)
- Lawson, JD; Co, EW; Stafford, JA HSP90 inhibitors US Patent US8618290 (2013)
- Vasioukhin, VI; Chevillet, JR Hepsin inhibitors US Patent US9182402 (2015)
- Mautino, M; Kumar, S; Waldo, J; Jaipuri, F; Kesharwani, T; Zhang, X IDO inhibitors US Patent US10233190 (2019)
- TERSTIEGE, I; SCHIESSER, S IRAK4 Inhibitors US Patent US20240300923 (2024)
- Mohan, R; Nuss, J; Harris, J; Yuan, S JAK inhibitors US Patent US11136329 (2021)
- Mansoor, UF; Fischer, C; Siliphaivanh, P; Torres, L; Gunaydin, H; Sloman, DL KDM5 inhibitors US Patent US10975084 (2021)
- Tamayo, NA; Banerjee, A; Chen, JJ; Low, JD; Minatti, AE; Bourbeau, MP KIF18A inhibitors US Patent US11236069 (2022)
- FINK, BE; CHERNEY, RJ; NGU, K; VELAPARTHI, U; VACCARO, WD; RUAN, Z; QIN, L; SHIRUDE, PS; RAHAMAN, H KRAS INHIBITORS US Patent US20240217982 (2024)
- Baker, TM; Fyfe, MC; Harbottle, GW; Hasimbegovic, V; Meghani, P; Rigby, A; Sambrook-Smith, C; Thom, SM Kinase inhibitors US Patent US10435361 (2019)
- Jensen, T; Jessing, M; Yu, W; Diaz, DR; Nielsen, J; Jones, CR; Andersen, T; Jacobsen, MF LRRK2 inhibitors US Patent US11780851 (2023)
- Marx, MA; Vaisburg, A; Christensen, JG; Galemmo, Jr., RA LSD1 inhibitors US Patent US10233152 (2019)
- Grice, CA; Buzard, DJ; Shaghafi, MB MAGL inhibitors US Patent US11332453 (2022)
- D., BJ; J., BM; T., CJ; A., DT; L., KJ; V., MC; Emanuele, P MAP4K1 INHIBITORS WIPO WO2023288264 (2023)
- Brubaker, JD; Miduturu, CV; Burke, MJ; Dineen, TA; Kim, JL; Close, JT; Perola, E MAP4K1 inhibitors US Patent US11534441 (2022)
- Schneider, M; Newton, G; Chapman, K; Perrior, T; Jarvis, A; Low, C; Aqil, R; Fisher, M; Bayford, M; Chapman, N; Martin, N; Reisinger, T; Negoita-Giras, G; Fieldler, LR MAP4K4 inhibitors US Patent US11795169 (2023)
- Krum, H; Scammells, P; Wang, B; Vinh, N; Simpson, J; Chalmers, D MAPK inhibitors US Patent US11273153 (2022)
- Chu, H; Guerrero, JA; Hurtley, AE; Jiang, L; Kato, D; Kobayashi, T; Lin, DW; Medley, JW; Naduthambi, D; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H; Zhu, Q MCL1 inhibitors US Patent US11667652 (2023)
- MO, C; Xu, X MNK INHIBITORS US Patent US20240092799 (2024)
- Rai, R; Pandey, A; Holsinger, LJ MYST Inhibitors US Patent US20250122182 (2025)
- Subbiah, R; Mollard, AH; Bearss, DJ; Kauwe, III, JS NEK7 INHIBITORS US Patent US20240158394 (2024)
- Hughes, AD; Fenster, E; Fleury, M; Gendron, R; Moran, EJ NEPRILYSIN INHIBITORS US Patent US20230285340 (2023)
- Zhang, Z; Wang, X; Su, Y; Ruan, H; Ren, Y Necrosis inhibitors US Patent US10092529 (2018)
- Fleury, M; Hughes, AD Neprilysin inhibitors US Patent US10829438 (2020)
- Wu, J; Vaid, TM; Kim, H; Lu, J; Li, M; Fung, LW; Johnson, ME PLPRO INHIBITORS US Patent US20250059159 (2025)
- BARLAAM, B POLQ INHIBITORS US Patent US20250195530 (2025)
- Stupple, PA; Walker, SR; Camerino, MA PRMT5 inhibitors US Patent US10961256 (2021)
- Anderson, KC; Hideshima, T; Dhe-Paganon, S; Seo, H; Mizutani, T; Zhang, T PRPK INHIBITORS US Patent US20230271966 (2023)
- Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J PTPN11 inhibitors US Patent US11104675 (2021)
- Shen, D; Debenham, JS; Graham, TH; Clements, MJ; Zhang, Y Prolylcarboxypeptidase inhibitors US Patent US8669252 (2014)
- Stranix, BR; Lavallee, J; Leberre, N; Perron, V; Herbart, D; Milot, G; Panchal, C Protease inhibitors US Patent US8742158 (2014)
- Castro, AC; McComas, CC; Vacca, J RAD51 inhibitors US Patent US11291655 (2022)
- Bhamidipati, S; Shaw, S; Darwish, I; Yu, J; Kolluri, R; Taylor, V; Masuda, E; Irving, M RIP1K inhibitors US Patent US11667643 (2023)
- Koltun, ES; Cregg, J; Gill, AL; Buckl, A; Liu, Y Ras inhibitors US Patent US11566007 (2023)
- Rabinowitz, JD; Kim, H; Ducker, GS; Ghergurovich, JM SHMT inhibitors US Patent US10934305 (2021)
- Chiang, GG; Pappano, WN; Sweis, RF; Wang, Z SMYD2 inhibitors US Patent US9598381 (2017)
- Marx, MA; Ketcham, JM; Smith, CR; Lawson, JD; Burns, AC; Wang, X; Kulyk, S; Ivetac, A SOS1 inhibitors US Patent US11702418 (2023)
- Blomgren, PA; Clarke, A; Currie, KS; Di Paolo, J; Kropf, JE; Lee, SH; Lo, JR; Mitchell, SA; Schmitt, AC; Swaminathan, S; Xiong, J; Xu, J; Zhao, Z Syk inhibitors US Patent US9504684 (2016)
- Genung, N; Levin, TH TYK2 INHIBITORS US Patent US20240360157 (2024)
- BEARSS, DJ; KAUWE, III, JS; MOLLARD, AH TYRO3 INHIBITORS US Patent US20240425499 (2024)
- Chobanian, H; Biftu, T; Pio, B; Wu, Z Thrombin inhibitors US Patent US9469608 (2016)
- Kluge, A; Lagu, B; Maiti, P; Panigrahi, SK USP30 inhibitors US Patent US10968172 (2021)
- Martinelli, R; Bond, JF USP9X Inhibitors US Patent US20240294467 (2024)
- Foitzik, RC; Morrow, BJ; Hemley, CF; Lunniss, GE; Camerino, MA; Ganame, D; Stupple, PA; Lessene, R; Kersten, WJ; Harvey, AJ; Holmes, IP VEGFR3 inhibitors US Patent US9238644 (2016)
- Li, D; West, AV; Caravella, J; Genung, NE; Bartels, F; Dow, RL; Leit de Moradei, SM; Sitnikov, N WRN INHIBITORS US Patent US20250034136 (2025)
- AHMED, A; MARTINEZ BROKAW, C; CARSON, CA; CONNER, SE; FORTNER, KC; FRANCISKOVICH, JB; GERNERT, DL; GREEN, SJ; LUGAR, III, CW; MARIMUTHU, J; NAGARAJAN, S; NICOLAOU, C; ONOBUN, E; STOUT, SL; TROMICZAK, EG; VARIN, T cGAS INHIBITORS US Patent US20230391786 (2023)
- Broom, AD Rational design of enzyme inhibitors: multisubstrate analogue inhibitors. J Med Chem 32: 2-7 (1989)
- Cherney, RJ; King, BW; Gilmore, JL; Liu, RQ; Covington, MB; Duan, JJ; Decicco, CP Conversion of potent MMP inhibitors into selective TACE inhibitors. Bioorg Med Chem Lett 16: 1028-31 (2006)
- Brem, J; Schofield, CJ; Cahill, ST; Calvopina, K; Hinchcliffe, P; Cain, R; Spencer, J; Fishwick, CW; Avison, MB β-lactamase inhibitors US Patent US11980631 (2024)
- Herath, S; Urbano, M; Kim, E; Chen, C; Li, Q; Ayers, J; Nakamura, K; Zhu, X; Rosen, H; Rosenblum, JS; Zhang, MC; Liu, Y; Ueno, M 15-PGDH inhibitors US Patent US12304897 (2025)
- Hearn, BR; Myles, DC; Chawla, R; Yeghikyan, D; Venkateshappa, C; Samajdar, S; Bera, K; Gore, ST; Ng, RA ACYLSULFONAMIDE KAT6A INHIBITORS US Patent US20250136553 (2025)
- Cheng, D; Ding, Q; He, Z; Zhou, X; Zhou, Y; Yin, X; Xie, Z AMINOHETEROARYL KINASE INHIBITORS US Patent US20240166635 (2024)
- CIAMMAICHELLA, A; DI FABIO, R; FERRIGNO, F; FEZZARDI, P; MONTALBETTI, C; PETROCCHI, A; RELITTI, N; ROSSETTI, I; SFERRAZZA, A; TORRENTE, E; FERRANTE, L; GRILLO, A AZABICYCLIC SHP2 INHIBITORS US Patent US20240109900 (2024)
- Kaiser, TM AZAINDOLE ROCK INHIBITORS US Patent US20240246972 (2024)
- Chen, Z; Cogan, D; Guo, X; Marshall, DR; Meyers, KM; Zhang, Y Aldosterone synthase inhibitors US Patent US9890171 (2018)
- Blass, B Aldosterone synthase inhibitors. ACS Med Chem Lett 4: 375-6 (2013)
- Sayre, LM Amine oxidase inhibitors US Patent US9161922 (2015)
- Quattropani, A; Kulkarni, SS; Giri, AG Annulated glycosidase inhibitors US Patent US11458140 (2022)
- Guo, X; Man, CC; Takahashi, H Azaquinazolinediones chymase inhibitors US Patent US8501749 (2013)
- Kysil, V; Parchinsky, VZ; Pushechnikov, A; Ivachtchenko, AV; Abagyan, R; Savchuk, N BCL-2 Inhibitors US Patent US20250115577 (2025)
- Chen, Y; Lou, Y BCL-2 inhibitors US Patent US10377755 (2019)
- Schönbrunn, E; Lawrence, NJ; Lawrence, HR; Reuther, G BRD4-JAK2 inhibitors US Patent US12391676 (2025)
- Guo, Y; Xue, H; Wang, Z; Sun, H Bcl-2 inhibitors US Patent US11420968 (2022)
- Dombroski, MA; Letavic, MA; McClure, KF; Barberia, JT; Carty, TJ; Cortina, SR; Csiki, C; Dipesa, AJ; Elliott, NC; Gabel, CA; Jordan, CK; Labasi, JM; Martin, WH; Peese, KM; Stock, IA; Svensson, L; Sweeney, FJ; Yu, CH Benzimidazolone p38 inhibitors. Bioorg Med Chem Lett 14: 919-23 (2004)
- Blizzard, TA; Chen, H; Gude, C; Hermes, JD; Imbriglio, J; Kim, S; Wu, JY; Mortko, CJ; Mangion, I; Rivera, N; Ruck, RT; Shevlin, M Beta-lactamase inhibitors US Patent US8487093 (2013)
- Luo, G; Dzierba, CD; Macor, JE Biaryl kinase inhibitors US Patent US10981910 (2021)
- Hummel, J; Hie, L; Lacharity, JJ; Li, X; Qian, D; Wang, X; Wei, B Bicyclic DGK Inhibitors US Patent US20250066363 (2025)
- Wang, J; Zang, W; Liu, J; Zheng, W Bivalent SIRT1 inhibitors. Bioorg Med Chem Lett 27: 180-186 (2017)
- Mindich, AL; Chestnova, AJ; Kasatkina, MA; Alafinov, AI; Gavrilov, AS; Evdokimov, AA; Lenshmidt, LV; Maksimenko, EA; Mishina, MS; Silonov, SA; Smirnov, EJ; Iakovlev, PA; Morozov, DV CDK8/19 inhibitors US Patent US11840531 (2023)
- Stauffer, SR; Heemers, HV; Macdonald, JD; Ben-Salem, S; Maw, J; Arya, T; Sonawane, DP; Coker, JA CITRON KINASE INHIBITORS US Patent US20250243196 (2025)
- Richardson, TE; Higgin, M; MacDonald, T Calcium channel inhibitors US Patent US11130750 (2021)
- Chuang, C; Morgan, BP Cardiac sarcomere inhibitors US Patent US12065436 (2024)
- Fang, L; Wang, Y; Ma, T; Song, L; Huang, Z; Yang, J; Gu, S Cathepsin L inhibitors US Patent US11858905 (2024)
- GEGE, C; KOHLHOF, H; MÜHLER, A; VITT, D DEUTERATED DHODH INHIBITORS US Patent US20240199535 (2024)
- Lindsey, D; Scott, K DIHYDROOROTATE DEHYDROGENASE INHIBITORS WIPO WO2022070071 (2022)
- Chang, K; Kim, Y; Groutas, WC; Perlman, S Deuterated protease inhibitors US Patent US12180156 (2024)
- Chen, Z; Creighton, CJ; Cunningham, M; Finn, J; Hilgers, M; Jung, M; Kohnen, LA; Lam, T; Li, X; Stidham, M; Tari, L; Trzoss, M; Zhang, J Dihydrofolate reductase inhibitors US Patent US8835445 (2014)
- Thunuguntla, SS; Subramanya, H; Kunnam, SR; Sanivaru Vijay, SR; Bingi, C; Kusanur, R; Schwarz, M; Arlt, M Dihydroorotate dehydrogenase inhibitors US Patent US9006454 (2015)
- Ahmad, S; Negash, LA Dihydropyridinone MGAT2 inhibitors US Patent US9365558 (2016)
- Li, Z; Zhong, W; Wang, J; Zeng, Q; Tsui, H; Yang, Z; Zhang, X ErbB receptor inhibitors US Patent US10822334 (2020)
- Yang, Z; Zhang, X ErbB/BTK inhibitors US Patent US11896597 (2024)
- Voss, M; Sone, H; Chackalamannil, S; Ohkouchi, M Factor IXa inhibitors US Patent US8980916 (2015)
- Xu, J; Ali, A; Zhou, W; Gao, Y; Edmondson, SD; Mertz, E; Neelamkavil, SF; Liu, W; Sun, W; Shen, D; Harper, B; Zhu, C; Bara, T; Lim, Y; Yang, M Factor XIA inhibitors US Patent US10214512 (2019)
- Hicks, JD; McKittrick, BA; Whitehead, BR; Lombardo, M; Han, X; Taylor, JA; Chu, HD; So, S; Orth, P; Wu, Z Factor XIIa inhibitors US Patent US11014920 (2021)
- Neelamkavil, SF; Edmondson, SD; Guo, Z; Hruza, AW; Hussain, Z; Lesburg, CA; Moningka, R; Ogawa, AK; Mal, R Factor XIa inhibitors US Patent US9663527 (2017)
- Liu, W; Edmondson, SD; Guo, Z; Mertz, E; Ogawa, AK; So, S; Sun, W; Brockunier, LL; Ali, A; Kuang, R; Wu, H Factor Xla inhibitors US Patent US9783530 (2017)
- Ding, P; Gelman, M; Kinsella, T; Singh, R; Bhamidipati, S; Velaparthi, U; Borzilleri, RM; Rahaman, H; Warrier, JS GDF-8 inhibitors US Patent US9981944 (2018)
- Gil, AM; Padilla, MM; Cascon, MA; Huerta, AF; Rico, ML; Puerto, MJ; Morera, AC; Aparicio, EM GSK-3 inhibitors US Patent US8686042 (2014)
- Wu, W; Burnett, DA Gamma secretase inhibitors US Patent US9226927 (2016)
- Kalayanov, G; Torssell, S; Wahling, H HCV polymerase inhibitors US Patent US10106571 (2018)
- Boyd, MJ; Molinaro, C; Roy, A; Truong, V HIV protease inhibitors US Patent US9079834 (2015)
- Dahmann, G; Hoffmann, M; Klicic Badoux, J; Lamb, DJ; McCarthy, C; Napier, SC; Parrish, K; Scott, J; Fitzgerald, JL; Walker, E Heteroaryl SYK inhibitors US Patent US10947243 (2021)
- Dahmann, G; Hoffmann, M; Klicic, J; Lamb, DJ; McCarthy, C; Napier, SC; Parrish, K; Scott, J; Fitzgerald, JL; Walker, E Heteroaryl Syk inhibitors US Patent US9914735 (2018)
- Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent US10793535 (2020)
- Burger, M; Lan, J Heterocyclic kinase inhibitors US Patent US8759338 (2014)
- Rajagopal, S; Kachhadia, V; Ponpandian, T; Keeri, AR; Mani, U; Rathinasamy, S; Rajendran, P; Mani, K; Ramachandran, B; Narayanaswamy, P; Rajagopal, S Histone deacetylase inhibitors US Patent US8476255 (2013)
- Miller, TA; Witter, DJ; Belvedere, S Histone deacetylase inhibitors. J Med Chem 46: 5097-116 (2003)
- Chen, YK; Nie, Z; Stafford, JA; Veal, JM Histone demethylase inhibitors US Patent US9896436 (2018)
- Zawadzka, A; Czarnocki, Z; Lozinska, I; Moleda, Z; Panasiewicz, M Hybrid cholinesterase inhibitors US Patent US8841453 (2014)
- Coates, DA; Frimpong, K; Holloway, WG; Jones, BS; Levinson, AM; Lugar, III, CW; Richett, ME; Watson, BM; Woodman, ME IL-17A inhibitors US Patent US12252491 (2025)
- HARDICK, DJ; Blackaby, WP; Thomas, EJ; Brookfield, FA; Shepherd, J; Bubert, C; Ridgill, MP INHIBITORS OF METTL3 US Patent US20240101589 (2024)
- INGHARDT, T; LINDSTEDT, E; JURVA, U; SELMI, N INHIBITORS OF MYELOPEROXIDASE US Patent US20240166642 (2024)
- Josef, TT; David, O; Pascal, F; Klaus, W; Achim, S INTERLEUKIN-17 INHIBITORS WIPO WO2022091056 (2022)
- Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent US10842803 (2020)
- Bohmann, JA; Gutierrez, NM; Mcdonough, JA; Campbell, RF; Joyce, MG; Panchal, R; Sankhala, R; Duplantier, A Inhibitors for coronavirus US Patent US11963959 (2024)
- Hachtel, S; Dedio, J; Shimshock, S; Lanter, C Inhibitors of CXCR2 US Patent US8552033 (2013)
- Aube, J; Scott, EE; Fehl, C Inhibitors of CYP17A1 US Patent US9611270 (2017)
- de Vicente Fidalgo, J; Hermann, JC; Lemoine, R; Li, H; Lovey, AJ; Sjogren, EB; Soth, M Inhibitors of JAK US Patent US8618103 (2013)
- Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 (2013)
- Chaturvedula, PV; Kimura, SR Inhibitors of PDE10 US Patent US8592423 (2013)
- Brubaker, JD; Kim, JL; Wilson, KJ; Wilson, D; DiPietro, LV Inhibitors of RET US Patent US11279688 (2022)
- Deshaies, RJ; Li, J; Cohen, S; Perez, C; Ma, Y Inhibitors of RPN11 US Patent US10005735 (2018)
- Bentley, J; Bosanac, T; Brearley, AS; Cooper, SC; Devraj, R; Hughes, RO; Jarjes-Pike, RA; Marlin, FJ; Parrott, SA; Silva, D Inhibitors of SARM1 US Patent US12331033 (2025)
- Turkson, J; Hamilton, AD Inhibitors of STAT3 US Patent US8969578 (2015)
- Bhagirath, N; Kennedy-Smith, J; Le, NT; Lucas, MC; Padilla, F; Soth, M Inhibitors of SYK US Patent US10112928 (2018)
- Bouyssou, T; Gottschling, D; Heine, N; Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent US10800757 (2020)
- Nilsson, KM; Astrand, AB; Berggren, AI; Johansson, JR; Lepisto, MJ; Kawatkar, SP; Su, Q; Kettle, JG JAK1 selective inhibitors US Patent US10961228 (2021)
- Dounay, AB; McAllister, L; Parikh, VD; Rong, S; Verhoest, PR KAT II inhibitors US Patent US8598200 (2013)
- ZHANG, G; MIAO, J; WANG, C; NI, Z; LI, H KRAS G12C INHIBITORS US Patent US20240166660 (2024)
- Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRAS G12D INHIBITORS US Patent US20230279025 (2023)
- Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRas G12D inhibitors US Patent US11453683 (2022)
- Linschoten, M Kallikrein 7 inhibitors US Patent US9744148 (2017)
- Klaveness, J; Sieng, B; Lundvall, S; Bøen, CA; Hnida, K LDHA activity inhibitors US Patent US11142520 (2021)
- Quattropani, A; Kulkarni, SS; Giri, AG Linear glycosidase inhibitors US Patent US11213525 (2022)
- Suzuki, T; Miyata, N Lysine demethylases inhibitors. J Med Chem 54: 8236-50 (2011)
- de Man, AP; Buijsman, RC; Sterrenburg, JG; de Wit, JJ; van Cauter, F; van Gemert, SP; Prinsen, MB; Mulder, WR; Muller, M; Vu-Pham, D; Grobben, Y; Simons-van Riel, WE; Van Mil, YG MACROCYCLIC BTK INHIBITORS US Patent US20250074911 (2025)
- Johansson, MH; Svensson, B; Borgström, B; Paulsen, F MACROCYCLIC TAK1 INHIBITORS US Patent US20240279233 (2024)
- Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H MCL-1 inhibitors US Patent US10988451 (2021)
- Thuring, JW; Bonfanti, J; Fortin, JM Macrocyclic integrase inhibitors US Patent US8497270 (2013)
- Lumeras Amador, W; Boulet, SL; Burkholder, TP; Carballares Martin, S; Gilmour, R; Hahn, PJ; Bauer, RA; Rankovic, Z Mutant IDH1 inhibitors US Patent US10696665 (2020)
- Farady, C; Gommermann, N; Janser, P; Mackay, A; Mattes, H; Smith, N; Solovay, CF; Stiefl, NJ; Vangrevelinghe, E; Velcicky, J; von Matt, A NLRP3 inflammasome inhibitors US Patent US11208399 (2021)
- Bagley, SW; Bootsma, AN; Choi, C; Dow, RL; Edmonds, DJ; Garcia-Irizarry, CN; Gerstenberger, BS; Ingle, G; O''Brien, JG; Parikh, MD; Rescourio, GC; Schmitt, DC NOVEL ACC INHIBITORS US Patent US20240109915 (2024)
- Cusack, KP; Hoemann, MZ; Kinsman, DA; Osman, S; Stambuli, JP; Argiriadi, MA; O''Reilly, C; Dexter, H; Fordyce, E; St. Gallay, S Nicotinamide RIPK1 inhibitors US Patent US11767310 (2023)
- Bootsma, AN; Ebner, DC; Kung, DW; Perry, MA; Schmitt, DC; Strohbach, JW; Thorarensen, A Novel SIK Inhibitors US Patent US20240124450 (2024)
- Ito, K; Strong, P; Rapeport, WG; Murray, PJ; King-Underwood, J; Williams, JG; Onions, S; Charron, CE P38MAP kinase inhibitors US Patent US9242960 (2016)
- Jabri, S; Ogawa, AK; Sinz, CJ; Hicks, JD; Cheng, AC; Gao, Y; Yang, S; Bao, J; Hayes, DA; Lang, SB; Taoka, BM; Tian, M; Shearn-Nance, GP; Kuang, R; Lombardo, MJ; Wu, Z; Zhao, Z PLASMA KALLIKREIN INHIBITORS US Patent US20230286958 (2023)
- Brown, DT; Christophersen, P; Jacobsen, TA; Larsen, JS; Poulsen, PH; Strøbaek, D Potassium channel inhibitors US Patent US12006289 (2024)
- Gardner, JH; Shalwitz, R; Wu, S Prolyl hydroxylase inhibitors US Patent US10562854 (2020)
- Zhang, J Protein kinase inhibitors US Patent US8598184 (2013)
- Kajino, M; Hasuoka, A; Tarui, N; Takagi, T Proton pump inhibitors US Patent US10308605 (2019)
- Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent US11655217 (2023)
- Reynolds, D; Hao, M; Wang, J; Prajapati, S; Satoh, T; Selvaraj, A Pyrimidine FGFR4 inhibitors US Patent US9730931 (2017)
- Kuduk, SD; McComas, CC; Reger, TS Pyrimidine PDE10 inhibitors US Patent US9663513 (2017)
- Chen, Z; Kim, SH; Barbosa, SA; Huynh, T; Tortolani, DR; Leavitt, KJ; Wei, DD; Manne, V; Ricca, CS; Gullo-Brown, J; Poss, MA; Vaccaro, W; Salvati, ME Pyrrolopyridazine MEK inhibitors. Bioorg Med Chem Lett 16: 628-32 (2005)
- Jacobsen, EJ; Anderson, DR; Blinn, JR; Hockerman, SL; Heier, R; Mukherjee, P Pyrrolopyrimidine ITK inhibitors US Patent US12297203 (2025)
- Dzierba, CD; Dasgupta, B; Macor, JE; Bronson, JJ; Rajamani, R; Karageorge, GN Pyrrolotriazine kinase inhibitors US Patent US9737542 (2017)
- DeLeon, P; Egbertson, M; Hills, ID; Johnson, AW; Machacek, M Quinolinone PDE2 inhibitors US Patent US8680116 (2014)
- Cox, CD; Flores, BA; Hostetler, E; Fan, H Radiolabeled PDE10 inhibitors US Patent US8846000 (2014)
- Ginn, JD; Marshall, DR; Sibley, R; Sorcek, RJ; Young, ER; Zhang, Y Rho kinase inhibitors US Patent US9079880 (2015)
- Shepard, S; Shao, L; Wang, X; Yue, EW SPIROCYCLIC LACTAM INHIBITORS US Patent US20250101020 (2025)
- Holmes, IP; Bergman, Y; Lunniss, GE; Nikac, M; Chol, N; Hemley, CF; Walker, SR; Foitzik, RC; Ganame, D; Lessene, R Selective FAK inhibitors US Patent US9120761 (2015)
- van Duzer, JH; Mazitschek, R Selective HDAC3 inhibitors US Patent US9096549 (2015)
- Ma, H; Filip, SV; Henry, MA; Dolan, JA; Dietrich, B Selective kinase inhibitors US Patent US8592415 (2013)
- Steinmetzer, T; Saupe, SM Serine protease inhibitors US Patent US8921319 (2014)
- Ondeyka, D; Qian, X; Vachal, P; Tyagarajan, S; Smith, CJ; Li, H; Bao, J Spirocyclic CETP inhibitors US Patent US9717714 (2017)
- Ding, F; Jiang, J; Shen, D; Shen, H; Shi, Z Spiropiperidine prolylcarboxypeptidase inhibitors US Patent US8785634 (2014)
- Quattropani, A; Kulkarni, SS; Giri, AG Sulfoximine glycosidase inhibitors US Patent US11261183 (2022)
- Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, CP; Rahaman, H; Warrier, JS TGF-β inhibitors US Patent US10287295 (2019)
- Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, C; Rahaman, H; Warrier, JS TGF-beta inhibitors US Patent US9884868 (2018)
- Li, D; West, AV; Caravella, J; Genung, NE; Bartels, F; Dow, RL; Leit de Moradei, SM; Sitnikov, N TRIAZOLO WRN INHIBITORS US Patent US20250129069 (2025)
- Hutchinson, JH; Lonergan, D; Rowbottom, M; Lai, AG Tetracyclic autotaxin inhibitors US Patent US9926318 (2018)
- Ammann, S; Bacon, EM; Brizgys, G; Chin, E; Chou, C; Cottell, JJ; Ndukwe, M; Shatskikh, M; Taylor, JG; Wright, NE; Yang, Z; Zipfel, SM Thiadiazole IRAK4 inhibitors US Patent US11702414 (2023)
- Barrow, JC; Cox, CD; Nolt, MB; Shipe, WD Triazolopyridinone PDE10 inhibitors US Patent US9266881 (2016)
- Cox, CD; Dudkin, VY; Kim, JJ; Kuduk, SD; McVean, CA; Reger, T; Sheen, JT; Steele, T Triazolyl PDE10 inhibitors US Patent US9200001 (2015)
- Xu, Y; Halcomb, R; Kirschberg, TA; Romero, FA Tricyclic ASK1 inhibitors US Patent US10919911 (2021)
- Owens, TD Tyrosine kinase inhibitors US Patent US9688676 (2017)
- ILIOPOULOS, D; HO, DG; ASAD, S; KARAGIANNIDIS, I VANIN-1 INHIBITORS US Patent US20250066353 (2025)
- Halim, R; Harding, M; Hufton, R; Morton, CJ; Jahangiri, S; Pool, BR; Jeynes, TP; Draffan, AG; Frey, B; Lilly, MJ Viral polymerase inhibitors US Patent US8546389 (2013)
- Risley, JM; Huang, DH; Kaylor, JJ; Malik, JJ; Xia, YQ Glycosylasparaginase inhibition studies: competitive inhibitors, transition state mimics, noncompetitive inhibitors. J Enzym Inhib 16: 269-74 (2001)
- Harriman, GC; Brewer, M; Bennett, R; Kuhn, C; Bazin, M; Larosa, G; Skerker, P; Cochran, N; Gallant, D; Baxter, D; Picarella, D; Jaffee, B; Luly, JR; Briskin, MJ Selective cell adhesion inhibitors: Barbituric acid based alpha4beta7--MAdCAM inhibitors. Bioorg Med Chem Lett 18: 2509-12 (2008)
- Lindsley, CW; Zhao, Z; Leister, WH; Robinson, RG; Barnett, SF; Defeo-Jones, D; Jones, RE; Hartman, GD; Huff, JR; Huber, HE; Duggan, ME Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett 15: 761-4 (2005)
- Ren, X; Hess, R; Hummel, J; Lacharity, JJ; Li, X; Manns, S; Qian, D; Wang, X; Wei, B COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS US Patent US20250186450 (2025)
- Innocenti, A; Maresca, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors? Bioorg Med Chem Lett 18: 3938-41 (2008)
- St-Denis, Y; Lévesque, S; Bachand, B; Edmunds, JJ; Leblond, L; Préville, P; Tarazi, M; Winocour, PD; Siddiqui, MA Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors. Bioorg Med Chem Lett 12: 1181-4 (2002)
- De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 (2015)
- Luo, G; Chen, L Acyl sulfonamide NaV1.7 inhibitors US Patent US10550080 (2020)
- Cox, CD; Raheem, IT; Shipe, WD; Theberge, CR Alkoxy pyrimidine PDE10 inhibitors US Patent US8785467 (2014)
- Cee, V; Chavez, Jr., F; Chen, JJ; Harrington, EH; Herberich, B; Jackson, CL; Lanman, BA; Nguyen, TT; Norman, MH; Pettus, LH; Reed, AB; Smith, AL; Tamayo, NA; Tasker, A; Wang, H; Wu, B; Wurz, R Amides as pim inhibitors US Patent US9394297 (2016)
- Coates, DA; Qin, LH; Wei, Y; Zhou, J Amino pyrimidine SSAO inhibitors US Patent US10464928 (2019)
- Coates, DA; Qin, LH; Wei, Y; Zhou, J Amino pyrimidine ssao inhibitors US Patent US10793552 (2020)
- Mertzman, ME; Dzierba, CD; Guernon, JM; Hart, AC; Luo, G; Macor, JE; Pitts, WJ; Shi, J; Spergel, SH Aminoimidazopyridazines as kinase inhibitors US Patent US11440913 (2022)
- Contreras, JM; Rival, YM; Chayer, S; Bourguignon, JJ; Wermuth, CG Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem 42: 730-41 (1999)
- Childers, KK; Haidle, AM; Machacek, MR; Northrup, AB Aminopyrimidines as SYK inhibitors US Patent US8759366 (2014)
- Altman, MD; Childers, KK; Di Francesco, ME; Ellis, JM; Fischer, C; Grimm, J; Haidle, AM; Kattar, SD; Northrup, AB; Otte, RD; Petrocchi, A; Schell, AJ; Zhou, H Aminopyrimidines as Syk inhibitors US Patent US9290490 (2016)
- Woods, KW; Lai, C; Miyashiro, JM; Tong, Y; Florjancic, AS; Han, EK; Soni, N; Shi, Y; Lasko, L; Leverson, JD; Johnson, EF; Shoemaker, AR; Penning, TD Aminopyrimidinone cdc7 kinase inhibitors. Bioorg Med Chem Lett 22: 1940-3 (2012)
- Watterson, SH; Andappan Murugaiah Subbaiah, M; Dzierba, CD; Gong, H; Guernon, JM; Guo, J; Hart, AC; Luo, G; Macor, JE; Pitts, WJ; Shi, J; Venables, BL; Weigelt, CA; Wu, Y; Zheng, ZB; Sit, S; Chen, J Aminopyrrolotriazines as kinase inhibitors US Patent US11618753 (2023)
- Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent US10603330 (2020)
- Steurer, S; Ettmayer, P; Mantoulidis, A B-RAF kinase inhibitors US Patent US9290507 (2016)
- Bosanac, T; Hughes, RO; Devraj, R; Parrott, SA BENZOPYRAZOLE INHIBITORS OF SARM1 US Patent US20240051939 (2024)
- Chen, Y; Masuda, E; Lamagna, C BICYCLIC INHIBITORS OF IRAK US Patent US20230391748 (2023)
- Liu, J; Kozlowski, JA; Alhassan, A; Boga, SB; Gao, X; Guiadeen, DG; Wang, J; Yu, W; Cai, J; Liu, S; Wang, D; Wu, H; Yang, C Benzamide imidazopyrazine Btk inhibitors US Patent US10087188 (2018)
- Burns, C; Garnier, J; Sharp, PP; Feutrill, J; Cuzzupe, A Benzodiazepines as bromodomain inhibitors US Patent US10167292 (2019)
- Groendyke, BJ; Powell, CE; Feru, F; Gero, TW; Li, Z; Szabo, H; Pang, K; Feutrill, J; Chen, B; Li, B; Gray, NS; Scott, DA Benzopyrimidodiazepinone inhibitors of TNK2. Bioorg Med Chem Lett 30: (2020)
- Gong, X; Barrett, K; Cao, J; Gritzen, C; Noronha, G; Hood, JD; Mak, CC; McPherson, A; Pathak, VP; Renick, J; Soll, RM; Splittgerber, U; Wrasidlo, W; Zeng, B; Zhao, N; Dneprovskaia, E Benzotriazine inhibitors of kinases US Patent US8481536 (2013)
- Deschenes, D; Altman, MD; Ellis, JM; Fischer, C; Haidle, AM; Kattar, SD; Northrup, AB; Schell, AJ; Smith, GF; Taoka, BM; Bienstock, C; Di Francesco, ME; Donofrio, A; Peterson, S; Spencer, KB; Jewell, JP; Ali, A; Bennett, DJ; Dang, Q; Wai, J Bipyridylaminopyridines as Syk inhibitors US Patent US9145391 (2015)
- Gao, Y; van Haren, MJ; Moret, EE; Rood, JJM; Sartini, D; Salvucci, A; Emanuelli, M; Craveur, P; Babault, N; Jin, J; Martin, NI Bisubstrate Inhibitors of Nicotinamide J Med Chem 62: 6597-6614 (2019)
- Li, Z; Zancanella, M; Yu, C; Setti, LQ; Sham, H; Xu, Q; Yee, CW; Yu, M Bridged bicyclic kallikrein inhibitors US Patent US10144746 (2018)
- Behenna, DC; Chen, P; Freeman-Cook, KD; Hoffman, RL; Jalaie, M; Nagata, A; Nair, SK; Ninkovic, S; Ornelas, MA; Palmer, CL; Rui, EY CDK2/4/6 inhibitors US Patent US10800783 (2020)
- PAN, G; ZHU, X; ZHU, Y COMPOUNDS AS C5AR INHIBITORS US Patent US20240043439 (2024)
- Pardin, C; Keillor, JW; Lubell, WD Cinnamoyl inhibitors of transglutaminase US Patent US9162991 (2015)
- Beaumont, EJ; Devraj, R; Kerry, PS; Kumaravel, G; Loke, PL; Meniconi, M; Palfrey, JJ; North, C; Lecci, C; Tye, H Covalent inhibitors of PAD4 US Patent US10703741 (2020)
- Chen, P; Cho-Schultz, S; Deal, JG; Gallego, GM; Jalaie, M; Kania, RS; Nair, SK; Ninkovic, S; Orr, ST; Palmer, CL Cyclin dependent kinase inhibitors US Patent US10766884 (2020)
- Arasappan, A; Cox, JM; Debenham, JS; Guo, Z; Lai, Z; Meng, D Cyclobutyl pyrazolopyrimidine PDE9 inhibitors US Patent US12247031 (2025)
- Kuduk, SD; Beshore, DC; Reger, TS Cyclopropyl imidazopyridine PDE10 inhibitors US Patent US9359348 (2016)
- Wu, L; Courter, JR; He, C; Wang, X; Yao, W; Zhang, F Cyclopropylamines as LSD1 inhibitors US Patent US11247992 (2022)
- SADHU, N; SIVANANDHAN, D; RASTELLI, L; GAJENDRAN, C; SRIDHARAN, R DUAL LSD1/HDAC INHIBITORS US Patent US20250162994 (2025)
- Ahn, K; Boehm, M; Cabral, S; Carpino, PA; Futatsugi, K; Hepworth, D; Kung, DW; Orr, S; Wang, J Diacylglycerol acyltransferase 2 inhibitors US Patent US9296745 (2016)
- Rosse, G Dihydropteridinone Inhibitors of BRD4. ACS Med Chem Lett 7: 131-131 (2016)
- Bothe, U; Günther, J; Nubbemeyer, R; Siebeneicher, H; Ring, S; Bömer, U; Peters, M; Rausch, A; Denner, K; Himmel, H; Sutter, A; Terebesi, I; Lange, M; Wengner, AM; Guimond, N; Thaler, T; Platzek, J; Eberspächer, U; Schäfer, M; Steuber, H; Zollner, TM; Steinmeyer, A; Schmidt, N Discovery of IRAK4 Inhibitors J Med Chem 67: 1225-1242 (2024)
- Wangtrakuldee, P; Byrd, MS; Campos, CG; Henderson, MW; Zhang, Z; Clare, M; Masoudi, A; Myler, PJ; Horn, JR; Cotter, PA; Hagen, TJ Discovery of Inhibitors of ACS Med Chem Lett 4: 699-703 (2013)
- Wright, SW; Nelson, MJ Episulfide inhibitors of lipoxygenase Bioorg Med Chem Lett 2: 1385-1390 (1992)
- Leffler, H; Nilsson, UJ; Von Wachenfeldt, H Galactoside inhibitors of galectins US Patent US8703720 (2014)
- Bandyopadhyay, A; Cheung, M; Eidam, HS; Joshi, H; Su, D Ghrelin O-acyltransferase inhibitors US Patent US11312709 (2022)
- Hitchcock, SA; Amegadzie, A; Qian, W; Xia, X; Harried, SS Glycine transporter-1 inhibitors US Patent US9663476 (2017)
- BETTIGOLE, S; SU, M; COGAN, DA; VAN BERKOM, L; NIECZYPOR, P; VAN DER HEIJDEN, G; VIJAYACHANDRAN, P HETEROCYCLIC INHIBITORS OF ENPP1 US Patent US20240376113 (2024)
- Gillis, EP; Bowsher, MS; Scola, PM Hepatitis C virus inhibitors US Patent US9334279 (2016)
- Devraj, R; Kumaravel, G; Lecci, C; Loke, PL; Meniconi, M; Monck, NJ; North, CL; Ridgill, MP; Tye, H Heteroaryl inhibitors of PAD4 US Patent US11026937 (2021)
- Gurney, ME; Hagen, TJ; Mo, X; Vellekoop, AS; Romero, DL; Campbell, R; Walker, JR; Zhu, L Heteroaryl inhibitors of PDE4 US Patent US11401286 (2022)
- Papaioannou, N; Travins, JM; Fink, SJ; Ellard, JM; Rae, A Heteroaryl plasma kallikrein inhibitors US Patent US11370803 (2022)
- Dineen, T; Marx, IE; Nguyen, HN; Weiss, M Heteroaryl sodium channel inhibitors US Patent US9079902 (2015)
- Bigi, S; Keung, W; Swann, S; Vu, PH; Woodhead, SJ; Gangloff, AR Heteroarylamide inhibitors of TBK1 US Patent US9994547 (2018)
- Vu, B; Dominique, R; Chen, Y; Li, H Heterocycles as WIP1 Inhibitors US Patent US20240116910 (2024)
- Shaw, S; Bhamidipati, S; Taylor, V Heterocyclic RIP1 kinase inhibitors US Patent US11479543 (2022)
- Parnell, KM; McCall, J; Romero, D Heterocyclic inhibitors of MCT4 US Patent US10214492 (2019)
- Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA Heterocyclic inhibitors of PTPN11 US Patent US10280171 (2019)
- Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic inhibitors of glutaminase US Patent US8604016 (2013)
- Li, Y; Yao, W; Combs, AP; Yue, EW; Mei, S; Glenn, J; Maduskuie, Jr., TP; Sparks, RB; Douty, B; He, C Heterocyclylamines as PI3K inhibitors US Patent US11433071 (2022)
- Chern, J; Yu, C; Liu, J; Ho, Y; Wu, C; Huang, C; Hung, P Histone deacetylases (HDACs) inhibitors US Patent US11535598 (2022)
- Blagg, B; Mishra, S Hsp90β selective inhibitors US Patent US12030867 (2024)
- Kotian, PL; Babu, YS; Wu, M; Chintareddy, VR; Kumar, VS; Zhang, W Human plasma kallikrein inhibitors US Patent US11230530 (2022)
- Meek, TD; Li, L; Tseng, CK; Drelich, A INHIBITORS OF CYSTEINE PROTEASES US Patent US20240150396 (2024)
- ORME, MW; ZUNIGA, ES; KUKSA, VA; CRAFT, RS; SAVEEDRA, EM; MEISSNER, JW; HARTOG, JA; DROS, AC INHIBITORS OF VAP-1 US Patent US20230295140 (2023)
- Zeng, Q; Wade, WS; Patterson, JB IRE-1α inhibitors US Patent US9493435 (2016)
- Vacca, JP; Bettigole, SE IRE1 small molecule inhibitors US Patent US11945784 (2024)
- Blagg, J; Drysdale, M; Clark, D; Winship, P ISOINDOLINES AS PMS2 INHIBITORS US Patent US20240425453 (2024)
- PubChem, PC Identify HuR specific inhibitors PubChem Bioassay (2015)
- Lynch, KR; Macdonald, TL; Mathews, TP; Kennedy, A; Kharel, Y Imidamide sphingosine kinase inhibitors US Patent US9421177 (2016)
- Kehler, J; Rasmussen, LK; Langgård, M; Jessing, M; Juhl, K; Vital, PJ Imidazopyrazinones as PDE1 inhibitors US Patent US11472810 (2022)
- Rosse, G Imidazopyridazine Inhibitors of PI3Kß. ACS Med Chem Lett 7: 1012-1013 (2016)
- Zhang, D; Xie, G Indolinone protein kinase inhibitors US Patent US9163010 (2015)
- Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Dorner-Ciossek, C; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Reeves, J; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Rast, G Inhibitors of β-secretase US Patent US8981112 (2015)
- Furuyama, H; Goto, Y; Kawanishi, N; Layton, ME; Mita, T; Ogino, Y; Onozaki, Y; Rossi, MA; Sakamoto, T; Sanderson, PE; Wang, J Inhibitors of AKT activity US Patent US8536193 (2013)
- Bock, MG; Gaul, C; Gunmadi, VR; Sengupta, S Inhibitors of CYP 17 US Patent USRE45173 (2014)
- Altman, MD; Andresen, BM; Brubaker, JD; Donofrio, A; Fischmann, T; Gibeau, CR; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF; Torres, L Inhibitors of IRAK4 activity US Patent US9943516 (2018)
- Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of LRRK2 kinase US Patent US11578061 (2023)
- Bearss, DJ; Kauwe, III, JS; Mollard, AH Inhibitors of NEK7 kinase US Patent US11713321 (2023)
- Bo, YY; Liu, L; Nishimura, N; Norman, MH; Siegmund, AC; Tamayo, NA; Yang, KC Inhibitors of PI3 kinase US Patent US8729074 (2014)
- Kaldor, SW; Kanouni, T; Murphy, E; Cox, J; Kania, R Inhibitors of RAF kinases US Patent US11377431 (2022)
- Orme, MW; Zuniga, ES; Kuksa, VA; Craft, RS; Saveedra, EM; Meissner, JW; den Hartog, JA; Dros, AC Inhibitors of VAP-1 US Patent US11787791 (2023)
- Bukhtiyarov, Y; Cacatian, S; Dillard, LW; Dorner-Ciossek, C; Fuchs, K; Jia, L; Lala, DS; Morales-Ramos, A; Reeves, J; Singh, SB; Venkatraman, S; Xu, Z; Yuan, J; Zhao, Y; Zheng, Y; Rast, G Inhibitors of beta-secretase US Patent US9949975 (2018)
- Desai, MC; Hui, HC; Liu, H; Sun, J; Xu, L Inhibitors of cytochrome P450 US Patent US8987313 (2015)
- Clement, B; Kotthaus, J; Schade, D Inhibitors of dimethylarginine dimethylaminohydrolase US Patent US8921421 (2014)
- Sun, D; McGee, LR; Du, X; Zhu, L; Yan, X; Rew, Y; Eksterowicz, J; Medina, JC; Zhou, H; Balbas, MD; Fantin, VR Inhibitors of glucocorticoid receptor US Patent US11124537 (2021)
- Heiser, U; Sommer, R; Gaertner, U; Hamann, A; Almstetter, M; Thormann, M; Treml, A; Demuth, H; Hoffman, T Inhibitors of glutaminyl cyclase US Patent US8962860 (2015)
- Holson, E; Wagner, FF; Haggarty, SJ; Zhang, Y; Lundh, M; Wagner, B; Lewis, MC; Petryshen, TL Inhibitors of histone deacetylase US Patent US11377423 (2022)
- Lohse, B; Kristensen, JL; Kristensen, LH; Agger, K; Helin, K; Gajhede, M; Clausen, RP Inhibitors of histone demethylases. Bioorg Med Chem 19: 3625-36 (2011)
- Abeywardane, A; Broadwater, J; Takahashi, H Inhibitors of leukotriene production US Patent US9303018 (2016)
- Konradi, A; Dominy, SS; Lynch, CC; Coburn, C; Vacca, J Inhibitors of lysine gingipain US Patent US9988375 (2018)
- Ferdinandy, P; Csont, TB; Csonka, C; Kedvesné Kupai, K; Kovács, L; Kis-Tamás, A; Takács, FT; Kónya, D; Medgyes, G; Cseh, S; Hajdú, I; Lörincz, Z; Dormán, G; Görbe, A Inhibitors of matrix metalloproteinases US Patent US9487462 (2016)
- Byun, DH; Cai, ZR; Canales, EY; Debien, LP; Hansen, TR; Huang, R; Jansa, P; Lee, RA; Loyer-Drew, JA; McFadden, R; Mitchell, ML; Pyun, H; Saito, RD; Sangi, MS; Schrier, AJ; Shatskikh, ME; Taylor, JG; Van Veldhuizen, JJ; Xu, L Inhibitors of peptidylarginine deiminases US Patent US11878965 (2024)
- Edwards, HJ; Evans, DM; Meghani, P; Novak, AR Inhibitors of plasma kallikrein US Patent US10221161 (2019)
- Bauer, SM; Jia, ZJ; Mehrotra, M; Song, Y; Xu, Q; Huang, W; Venkataramani, C; Rose, JW; Pandey, A Inhibitors of protein kinases US Patent US11414410 (2022)
- Zheng, X; Martin, MW; Ng, PY; Thomason, JR; Han, B; Rudnitskaya, A; Lancia, Jr., DR Isoindolines as HDAC inhibitors US Patent US11535607 (2022)
- Bosanac, T; Bentzien, J; Burke, MJ; DiSalvo, DT; Mao, W; Soleymanzadeh, F; Westbrook, JA; Xiong, Z Isoquinolones as BTK inhibitors US Patent US10570118 (2020)
- Li, A; Li, S; Wang, P; Dang, C; Liu, D KRAS mutant protein inhibitors US Patent US11345701 (2022)
- Dong, Q; Kaldor, SW MAPK/ERK kinase inhibitors US Patent US8470837 (2013)
- FLEURY, M; BARSANTI, PA; MCSPADDEN, ED METHIONINE ADENOSYLTRANSERASE 2A INHIBITORS US Patent US20250243188 (2025)
- Bobinski, TP; Smith, CR; Marx, MA; Ketcham, JM; Burns, AC; Lawson, JD; Kulyk, S; Kuehler, J; Ivetac, A MTA-cooperative PRMT5 inhibitors US Patent US11479551 (2022)
- Juhl, K; Jessing, M; Langgård, M; Vital, PJ; Kehler, J; Rasmussen, LK; Clementson, CM; Marigo, M Macrocycles as PDE1 inhibitors US Patent US10618913 (2020)
- Hoflack, J; Blom, P; Lavergne, O; Gomez, S Macrocyclic LRRK2 kinase inhibitors US Patent US10377772 (2019)
- Zhang, X; Glunz, P; Priestley, ES; Johnson, JA; Wurtz, NR; Ladziata, V Macrocyclic factor VIIa inhibitors US Patent US9174974 (2015)
- Wang, C; Corte, JR; Rossi, KA; Bozarth, JM; Wu, Y; Sheriff, S; Myers, JE; Luettgen, JM; Seiffert, DA; Wexler, RR; Quan, ML Macrocyclic factor XIa inhibitors. Bioorg Med Chem Lett 27: 4056-4060 (2017)
- Hendricks, RT; Stoycheva, AD; Bonfanti, J; Raboisson, PJ; Fortin, JM; Mercey, GJ Macrocyclic flu endonuclease inhibitors US Patent US11312727 (2022)
- Smallheer, JM; Kick, EK; Valente, MN; Hu, CH; Halpern, OS; Jusuf, S Macrocyclic inhibitors of myeloperoxidase US Patent US10577383 (2020)
- Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Hunter, D; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J; Bai, Y; Zheng, Z; Zhang, X Metallo-beta-lactamase inhibitors US Patent US10227331 (2019)
- Lee, J; Barczak, N; Escobedo, JA; Conti, C; Han, B; Lancia, Jr., DR; Liu, C; Martin, MW; Ng, PY; Rudnitskaya, A; Thomason, JR; Zheng, X Methods using HDAC11 inhibitors US Patent US10508088 (2019)
- Zeng, Q; Faris, M; Mollard, A; Warner, SL; Flynn, GA Multiple kinase pathway inhibitors US Patent US9714247 (2017)
- Brand, S; Wyatt, P; Thompson, S; Smith, V; Bayliss, T; Harrison, J; Norcross, N; Cleghorn, L; Gilbert, I; Brenk, R N-myristoyl transferase inhibitors US Patent US9156811 (2015)
- Curtin, ML; Sorensen, BK; Heyman, HR; Clark, RF; Woller, KR; Shah, OJ; Michaelides, M; Tse, C; Vasudevan, A; Mack, H; Hansen, TM; Sweis, R; Pliushchev, MA NAMPT and rock inhibitors US Patent US9302989 (2016)
- Omidkhah, N; Ghodsi, R NO-HDAC dual inhibitors. Eur J Med Chem 227: (2022)
- Miller, CA; Griffin, PR; Kamenecka, TM; Rumbaugh, G; Surman, M; Young, S; Duddy, S; Radnai, L NONMUSCLE MYOSIN II INHIBITORS US Patent US20250163056 (2025)
- SHARMA, R; BAHEKAR, R; PRAJAPATI, V; JOSHI, D; DAVE, K NOVEL INHIBITORS OF AUTOTAXIN US Patent US20240327407 (2024)
- BROWN, DT; CHRISTOPHERSEN, P; JACOBSEN, TA; LARSEN, JS; POULSEN, PH; STRØBAEK, D NOVEL POTASSIUM CHANNEL INHIBITORS US Patent US20240034717 (2024)
- Blass, BE Novel Potassium Channel Inhibitors. ACS Med Chem Lett 11: 2357-2358 (2020)
- Bell, AS; Yu, Z; Hutton, JA; Wright, MH; Brannigan, JA; Paape, D; Roberts, SM; Sutherell, CL; Ritzefeld, M; Wilkinson, AJ; Smith, DF; Leatherbarrow, RJ; Tate, EW Novel Thienopyrimidine Inhibitors of J Med Chem 63: 7740-7765 (2020)
- Caldwell, JP; De Jesus, R; Ding, F; Gill, CJ; Ho, GD; Ha, SN; Koseoglu, SJ; Labroli, MA; Lee, SH; Madsen-Duggan, C; Mandal, M; Roemer, T; Su, J; Tan, CM; Tan, Z; Tang, H; Wang, H; Yang, C; Yang, S Oxazolidinones as taro inhibitors US Patent US11141410 (2021)
- Converso, A; Kaufman, ML; Rodzinak, K Oxy-cyanoquinolinone PDE9 inhibitors US Patent US10370337 (2019)
- Wilson, JE; Brucelle, F; Levell, JR P300/CBP HAT inhibitors US Patent US11274090 (2022)
- Wilson, JE; Levell, JR P300/CBP hat inhibitors US Patent US11414384 (2022)
- King-Underwood, J; Ito, K; Strong, P; Rapeport, WG; Charron, CE; Murray, PJ; Williams, JG; Onions, ST P38 MAP kinase inhibitors US Patent US9260410 (2016)
- EWIN, RA; CURTIS, MP; MADDUX, TM; KYNE, GM PHOSPHODIESTERASE 3 (PDE3) INHIBITORS US Patent US20240308973 (2024)
- Liotta, D; Jecs, E; Altas Tahirovic, Y; Wilson, L; Pelly, S Pan-tropic entry inhibitors US Patent US11649235 (2023)
- Burns, CJ; Daigle, D; Chu, G; Hamrick, J; Boyd, SA; Zulli, AL; Mesaros, EF; Condon, SM; Trout, RE; Myers, CL; Xu, Z Penicillin-binding protein inhibitors US Patent US12173018 (2024)
- Piomelli, D; Clapper, JR; Moreno-Sanz, G; Duranti, A; Tontini, A; Mor, M; Tarzia, G Peripherally restricted FAAH inhibitors US Patent US9187413 (2015)
- Cofre, V; Converso, A; Rodzinak, K Phenyl-cyanoquinolinone PDE9 inhibitors US Patent US10370336 (2019)
- Du, Z; Evarts, J; Kaplan, J; Kim, M; Naduthambi, D; Patel, L; Perreault, S; Phillips, BW; Phillips, G; Stevens, KL; Treiberg, JA; Van Veldhuizen, J; Watkins, WJ; Yeung, SC Phosphatidylinositol 3-kinase inhibitors US Patent US10221197 (2019)
- Taddei, DM; Onions, ST; Smith, AJ; Copmans, AH; Broeckx, RL Phosphoinositide 3-kinase inhibitors US Patent US9227977 (2016)
- Piomelli, D; Scarpelli, R; Migliore, M; Heim, R; Garcia-Guzmàn, M Piperazinyl methanone NAAA inhibitors US Patent US10556892 (2020)
- Wang, S; Aguilar, A; Zheng, K; Xu, S; Xu, T; Bernard, D; Huang, L Piperidines as menin inhibitors US Patent US10899738 (2021)
- Wurtz, NR; Viet, A; Shaw, SA; Dilger, A; Valente, MN; Khan, JA; Jusuf, S; Narayanan, R; Fernando, G; Lo, F; Liu, X; Locke, GA; Kopcho, L; Abell, LM; Sleph, P; Basso, M; Zhao, L; Wexler, RR; Duclos, F; Kick, EK Potent Triazolopyridine Myeloperoxidase Inhibitors. ACS Med Chem Lett 9: 1175-1180 (2018)
- Iqbal, M; Chatterjee, S; Kauer, JC; Das, M; Messina, P; Freed, B; Biazzo, W; Siman, R Potent inhibitors of proteasome. J Med Chem 38: 2276-7 (1995)
- Mao, L; Xu, X; Shaabani, N; Jin, C Protease inhibitors as antivirals US Patent US11753373 (2023)
- Johnson, PD; Leach, A; Luke, RW; Matusiak, ZS; Morris, JJ Protein kinase B inhibitors US Patent US11236095 (2022)
- Devel, L; Beau, F; Czarny, B; Dive, V Pseudodipeptides as MMP inhibitors US Patent US8691753 (2014)
- Saxty, G; Hamlett, CC; Berdini, V; Murray, CW; Angibaud, PR; Querolle, OA; Poncelet, VS Pteridines as FGFR inhibitors US Patent US10272087 (2019)
- Cox, CD; Raheem, IT; Schreier, JD Pyrazolopyrimidine PDE 10 inhibitors US Patent US8957077 (2015)
- Vasbinder, MM; Schenkel, LB; Swinger, KK; Kuntz, KW Pyridazinones as PARP7 inhibitors US Patent US10870641 (2020)
- Mastracchio, A; Bruncko, M; Lai, C; Miyashiro, JM; Tao, Z; Woods, KW; Penning, TD; Souers, AJ Pyridine CDK9 kinase inhibitors US Patent US9650358 (2017)
- Li, Y; Metcalf, BW; Combs, AP Pyrimidinones as PI3K inhibitors US Patent US10829502 (2020)
- Zhang, J; Guo, C; Bouzida, D; Dong, L; Li, H; Marakovits, JT; Yang, A; Hong, Y Pyrrolopyrazoles, potent kinase inhibitors US Patent US8530652 (2013)
- Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent US10562891 (2020)
- Balasubramanian, G; Kilambi, N; Rathinasamy, S; Rajendran, P; Narayanan, S; Rajagopal, S Quinolone-based HDAC inhibitors. J Enzyme Inhib Med Chem 29: 555-62 (2014)
- Dominguez, C; Carini, D; Weber, P; Knabb, R; Alexander, R; Kettner, C; Wexler, R S1 heterocyclic thrombin inhibitors Bioorg Med Chem Lett 7: 79-84 (1997)
- Wein, MN; Greenlee, WJ SALT INDUCIBLE KINASE INHIBITORS US Patent US20240025892 (2024)
- Orsi, D; Wagner, FF; Corsello, S; Shekhar, M; Handing, K; Ferrara, SJ; McKinney, D; Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Christian, S; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Kaulfuss, S; Rupaimoole, R; Lienau, P; Brzezinka, K; Berger, M SUBSTITUTED HETEROCYCLIC CSNK1 INHIBITORS US Patent US20250188075 (2025)
- Jia, Z; Wu, Y; Pan, Y; Zhou, J; Li, Q Salts of TAM inhibitors US Patent US11104682 (2021)
- Vakkalanka, SK; Muthuppalaniappan, M; Nagarathnam, D Selective PI3K delta inhibitors US Patent US9150579 (2015)
- Shariat-Madar, Z; Rimoldi, JM; Gadepalli, RS Selective inhibitors of prolylcarboxypeptidase US Patent US9193762 (2015)
- Chang, M; Mobashery, S Selective matrix metalloproteinase inhibitors US Patent US9951035 (2018)
- Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent US9867833 (2018)
- Chiosis, G; He, H; Llauger-Bufi, L; Kim, J; Larson, SM; Smith-Jones, P Small-molecule HSP90 inhibitors US Patent US10676476 (2020)
- Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M Spiroindolinones as DDR1 inhibitors US Patent US10618897 (2020)
- Chen, Y; Ding, Q; Sun, Y Spiropyrrolidines as MDM2 inhibitors US Patent US9701685 (2017)
- Quattropani, A; Kulkarni, SS; Giri, AG Substituted dihydrobenzofuran glycosidase inhibitors US Patent US10995090 (2021)
- Dineen, T; Kreiman, C; Weiss, M; Geuns-Meyer, S Sulfamide sodium channel inhibitors US Patent US9051311 (2015)
- Frey, R; Gong, J; Ji, Z; Lai, C; Penning, T; Song, X; Souers, A; Tong, Y; Zhu, G Tetracyclic CDK9 kinase inhibitors US Patent US9328112 (2016)
- Quattropani, A; Kulkarni, SS; Giri, AG; Wishart, G; Rakesh, P Tetrahydro-benzoazepine glycosidase inhibitors US Patent US11795165 (2023)
- Foitzik, RC; Camerino, MA; Walker, SR; Lagiakos, HR Tetrahydroisoquinoline derived PRMT5-inhibitors US Patent US10647708 (2020)
- Bergman, YE; Camerino, MA; Walker, SR; Stupple, PA Tetrahydroisoquinolines as PRMT5 inhibitors US Patent US10421743 (2019)
- Guy, RK; Slavish, PJ; Shadrick, WR; Young, BM; Boyd, VA; Bharatham, N; Price, JE; Shelat, A Tetrahydroquinoline-based bromodomain inhibitors US Patent US11028051 (2021)
- Armbrust, K; Romanov Michailidis, F; Worm, KI; Ellis, JM Thienopyridine inhibitors of RIPK2 US Patent US11168093 (2021)
- Campbell, D; Chapman, J; Diraimondo, TR; Duron, SG Transglutaminase 2 (TG2) inhibitors US Patent US11548892 (2023)
- Cravatt, BF; Ogasawara, D; Viader, A; Deng, H; Van Der Wel, T; Van Der Stelt, M Triazole DAGLα inhibitors US Patent US10583137 (2020)
- Franzini, M; Ye, XM; Adler, M; Aubele, DL; Garofalo, AW; Gauby, S; Goldbach, E; Probst, GD; Quinn, KP; Santiago, P; Sham, HL; Tam, D; Truong, A; Ren, Z Triazolopyridazine LRRK2 kinase inhibitors. Bioorg Med Chem Lett 23: 1967-73 (2013)
- Smallheer, JM; Shaw, SA; Halpern, OS; Hu, CH; Kick, EK Triazolopyridine inhibitors of myeloperoxidase US Patent US10407422 (2019)
- Yang, W; Glunz, PW; Bhide, RS; Thiyagarajan, K Tricyclic rho kinase inhibitors US Patent US10654860 (2020)
- Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent US9328096 (2016)
- MacKeigan, JP; Ellsworth, E; Martin, KR; Aleiwi, BA ULK1 AND ULK2 INHIBITORS US Patent US20250059194 (2025)
- Alvarado, JR; Stauffer, SR; Gogliotti, RD; Han, C; Meyers, KM; Tian, J; Macdonald, JD; Fesik, SW; Lee, T WDR5 inhibitors and modulators US Patent US10844044 (2020)
- Brubaker, JD; Dai, Y; Dineen, TA; Du, G; Fang, C; Haidle, AM; Kim, JL; Perola, E; Samarakoon, T; Wilson, D WILD TYPE KIT INHIBITORS US Patent US20240262826 (2024)
- Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails. Bioorg Med Chem Lett 12: 1551-7 (2002)
- Wang, E; Casciano, CN; Clement, RP; Johnson, WW HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res 18: 800-6 (2001)
- Hou, W; Sun, H; Ma, Y; Liu, C; Zhang, Z Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors. J Med Chem 62: 5901-5919 (2019)
- Darras, FH; Kling, B; Heilmann, J; Decker, M Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer. ACS Med Chem Lett 3: 914-919 (2012)
- Madge, DJ; Hazelwood, R; Iyer, R; Jones, HT; Salter, M Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors Bioorg Med Chem Lett 6: 857-860 (1996)
- Adkison, KK; Barrett, DG; Deaton, DN; Gampe, RT; Hassell, AM; Long, ST; McFadyen, RB; Miller, AB; Miller, LR; Payne, JA; Shewchuk, LM; Wells-Knecht, KJ; Willard, DH; Wright, LL Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg Med Chem Lett 16: 978-83 (2006)
- Aoyama, Y; Uenaka, M; Konoike, T; Iso, Y; Nishitani, Y; Kanda, A; Naya, N; Nakajima, M 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma. Bioorg Med Chem Lett 10: 2403-6 (2001)
- Ramtohul, YK; Powell, D; Leclerc, JP; Leger, S; Oballa, R; Black, C; Isabel, E; Li, CS; Crane, S; Robichaud, J; Guay, J; Guiral, S; Zhang, L; Huang, Z Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors. Bioorg Med Chem Lett 21: 5692-6 (2011)
- Dener, JM; Wang, VR; Rice, KD; Gangloff, AR; Kuo, EY; Newcomb, WS; Putnam, D; Wong, M Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors. Bioorg Med Chem Lett 11: 2325-30 (2001)
- Esteves, MA; Ortet, O; Capelo, A; Supuran, CT; Marques, SM; Santos, MA New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors. Bioorg Med Chem Lett 20: 3623-7 (2010)
- Vaidya, GN; Rana, P; Venkatesh, A; Chatterjee, DR; Contractor, D; Satpute, DP; Nagpure, M; Jain, A; Kumar, D Paradigm shift of "classical" HDAC inhibitors to "hybrid" HDAC inhibitors in therapeutic interventions. Eur J Med Chem 209: (2021)
- Bachand, B; Tarazi, M; St-Denis, Y; Edmunds, JJ; Winocour, PD; Leblond, L; Siddiqui, MA Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors. Bioorg Med Chem Lett 11: 287-90 (2001)
- Hird, AW; Aquila, BM; Block, MH; Hennessy, EJ; Kamhi, VM; Omer, CA; Laing, NM; Saeh, JC; Sha, L; Yang, B Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors. Bioorg Med Chem Lett 24: 1820-4 (2014)
- Cox, CD; Beshore, DC; Kim, JJ; Kuduk, SD; McVean, CA; Reger, T; Sheen, JT 1,3 substituted azetidine PDE10 inhibitors US Patent US9365562 (2016)
- Bock, MG; Gaul, C; Gummadi, VR; Sengupta, S 17a-hydroxylase/C17,20-lyase inhibitors US Patent US9339501 (2016)
- Greenwood, JR; Harriman, GC; Borg, G; Masse, CE ACC inhibitors and uses thereof US Patent US10208044 (2019)
- Leit de Moradei, SM; Kreutter, K; Harwood, HJ; Therrien, E ACLY inhibitors and uses thereof US Patent US11492341 (2022)
- Liang, J; Jakalian, A; Lambrecht, MJ; Larouche-Gauthier, R; Huestis, M; Ung, MU; Wang, X; Yadav, A; Zbieg, JR; Broccatelli, F AMIDES AS CBL-B INHIBITORS US Patent US20240300927 (2024)
- ALFARO, J; BELMAR, S; NÚÑEZ VASQUEZ, GE; PUJALA, B; SATHE, BD; THAKRAL, P; PATIDAR, RK; BERNALES, S; CHAKRAVARTY, S ATF6 INHIBITORS AND USES THEREOF US Patent US20240124434 (2024)
- SHAN, B; HOU, B; YUWEN, H; CHEN, P; SHI, Z; GU, Z; CHEN, P; CAI, Z; MEI, J ATR INHIBITORS AND USES THEREOF US Patent US20230295166 (2023)
- Schüttelkopf, AW; Gros, L; Blair, DE; Frearson, JA; van Aalten, DM; Gilbert, IH Acetazolamide-based fungal chitinase inhibitors. Bioorg Med Chem 18: 8334-40 (2010)
- Sheppard, D; DeGrado, WF; Jo, H; Sundaram, A; Beresis, R Alpha-5 beta-1 inhibitors US Patent US11530180 (2022)
- Bagdanoff, JT; Ding, Y; Han, W; Huang, Z; Jiang, Q; Jin, JX; Kou, X; Lee, P; Lindvall, M; Min, Z; Pan, Y; Pecchi, S; Pfister, KB; Poon, D; Rauniyar, V; Wang, XM; Zhang, Q; Zhou, J; Zhu, S Aminoheteroaryl benzamides as kinase inhibitors US Patent US9242996 (2016)
- Notte, G Apoptosis signal-regulating kinase inhibitors US Patent US9051313 (2015)
- Lee, D; Bhat, KP; Fong, HH; Farnsworth, NR; Pezzuto, JM; Kinghorn, AD Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod 64: 1286-93 (2001)
- Vrudhula, VM; Dzierba, CD; Bronson, JJ; Macor, JE; Nara, SJ; Rajamani, R; Karatholuvhu, MS Aryl amide-based kinase inhibitors US Patent US9708337 (2017)
- Barber, J; Cho-Schultz, S; Del Bel, ML; Gallego, RA; He, M; Jalaie, M; Kania, RS; McTigue, MA; Nair, SK; Schmitt, AD; Tuttle, JB; Zhou, D; Zhou, R Azalactam compounds as HPK1 inhibitors US Patent US11684616 (2023)
- Wang, H; Cee, VJ; Herberich, BJ; Jackson, CL; Lanman, BA; Nixey, T; Pettus, LH; Reed, AB; Wu, B; Wurz, R; Tasker, A Azole compounds as PIM inhibitors US Patent US9321756 (2016)
- Cisar, J; Kuduk, S; DeRatt, L; Simonnet, YR BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS US Patent US20240158414 (2024)
- Brameld, KA; Owens, T Benzimidazole derivatives as ITK inhibitors US Patent US9573958 (2017)
- Aktoudianakis, E; Chin, G; Corkey, BK; Du, J; Elbel, K; Jiang, RH; Kobayashi, T; Lee, R; Martinez, R; Metobo, SE; Mish, M; Munoz, M; Shevick, S; Sperandio, D; Yang, H; Zablocki, J Benzimidazole derivatives as bromodomain inhibitors US Patent US9458145 (2016)
- Czardybon, W; Brzózka, K; Galezowski, M; Windak, R; Milik, M; Zawadzka, M; Guzik, P; Wincza, E; Prokop, M; Wiklik, K; Sabiniarz, A; Cholody, WM; Horvath, R; Rzymski, T Benzimidazole derivatives as kinase inhibitors US Patent US10174013 (2019)
- Bellenie, BR; Carter, MK; Cheung, KM; Davis, OA; Hoelder, S; Lloyd, MG; Varela Rodriguez, A; Woodward, H; Innocenti, P Benzimidazolone derived inhibitors of BCL6 US Patent US12110286 (2024)
- Shook, BC; Kim, IJ; Blaisdell, TP; Yu, J; Panarese, J; Or, YS Benzodiazepine derivatives as RSV inhibitors US Patent US11390631 (2022)
- Hocutt, FM; Leonard, Jr., BE; Peltier, HM; Phuong, VK; Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H; Zhao, LX Benzoimidazoles as prolyl hydroxylase inhibitors US Patent US11618744 (2023)
- Ye, Y; Li, Z; Qian, D; Winterton, S; Wu, L; Yao, W Bicyclic amines as CDK2 inhibitors US Patent US11851426 (2023)
- Combs, AP; Sparks, RB; Maduskuie, Jr., TP Bicyclic azaheterocyclobenzylamines as PI3K inhibitors US Patent US10259818 (2019)
- Vasudevan, A; Penning, TD; Chen, H; Liang, B; Wang, S; Wu, F; Shen, Y; Liu, C; Zou, Z; Pliushchev, M Bicyclic carboxamide inhibitors of kinases US Patent US9212192 (2015)
- Hert, J; Hunziker, D; Mattei, P; Rudolph, M; Schmitz, P; Di Giorgio, P Bicyclic compounds as ATX inhibitors US Patent US11673888 (2023)
- Sun, Y; Lu, L; Yao, W; He, C; Zhang, F Bicyclic heterocycles as FGFR inhibitors US Patent US10040790 (2018)
- Lu, L; Wu, L; Shen, B; Yao, W Bicyclic heterocycles as FGFR4 inhibitors US Patent US9801889 (2017)
- Fuller, NO; Lowe, III, JA Bicyclic inhibitors of histone deacetylase US Patent US11225479 (2022)
- Li, Y; Zhuo, J; Mei, S Bipyrazole derivatives as JAK inhibitors US Patent US9926301 (2018)
- Fandrick, K; Feng, X; Janowsky, A; Johnson, R; Cashman, JR Bivalent biogenic amine reuptake inhibitors. Bioorg Med Chem Lett 13: 2151-4 (2003)
- Bowlin, TL; Moir, DT; Chandran, K; Dye, Jr., JM; Williams, JD; Aron, ZD; Barbor, JP; Lively, KN; Nash, PJ; Mills, DM; Basu, A Broad spectrum inhibitors of filoviruses US Patent US11459308 (2022)
- Chesworth, R; Moradei, OM; Shapiro, G; Jin, L; Babine, RE CARM1 INHIBITORS AND USES THEREOF US Patent US20230279020 (2023)
- Huang, Z; Wang, T; Wang, C; Fan, Y CDK9 inhibitors in cancer research. RSC Med Chem 13: 688-710 (2022)
- FOURTOUNIS, J; YOUNG, J; BERNIER, C; DUROCHER, D; HUSTEDT, N COMBINATION THERAPIES INCLUDING MYT1 INHIBITORS US Patent US20240207300 (2024)
- XIE, Y; WU, Y; QIAN, L COMPOUNDS USED AS SRC INHIBITORS US Patent US20250042904 (2025)
- Kreutter, KD; Whitehead, L; West, AV; Albanese, SK; Verras, A; Robinson, S; Kaila, N; Campos, S; Demarco, K CTPS1 inhibitors and uses thereof US Patent US12331046 (2025)
- BRINER, K; CHEN, X; JOSEPH, S; RAUNIYAR, V; ZECRI, F CYCLIN-DEPENDENT KINASE (CDK2) INHIBITORS US Patent US20240360137 (2024)
- Levy, DE; Schulman, H; Paraselli, BR; Kumar, NS; Dabbugoddu, B; Balasubramanyam, C CaMKII inhibitors and uses thereof US Patent US11325908 (2022)
- Lim, J; Altman, MD; Childers, ML; Gibeau, CR; Ho, GD; Tsui, H Carboxamide inhibitors of IRAK4 activity US Patent US10155765 (2018)
- Parlati, F; Orford, K; Whiting, SH Combination therapy with glutaminase inhibitors US Patent US10278968 (2019)
- Cheung, M; Tangirala, RS Compounds as diacylglycerol acyltransferase inhibitors US Patent US9738658 (2017)
- Lim, J; Huang, X; Ferguson, RD; Zhou, W; Boyce, CW; Siliphaivanh, P; Witter, DJ; Maletic, MM; Kozlowski, JA; Wilson, KJ Compounds that are ERK inhibitors US Patent US10065967 (2018)
- Jordan, A; Newton, R; Hynd, G; Sutton, JM; Waszkowycz, B Compounds useful as RET inhibitors US Patent US11352361 (2022)
- Sparey, T; Beher, D; Best, J; Biba, M; Castro, JL; Clarke, E; Hannam, J; Harrison, T; Lewis, H; Madin, A; Shearman, M; Sohal, B; Tsou, N; Welch, C; Wrigley, J Cyclic sulfamide gamma-secretase inhibitors. Bioorg Med Chem Lett 15: 4212-6 (2005)
- Durón, SG; Chapman, J; Sydserff, SG; Rao, SG; Stein, G; Wade, W Cystathionine-γ-lyase (CSE) inhibitors US Patent US9725426 (2017)
- Durón, SG; Chapman, J; Sydserff, SG; Rao, SG; Stein, G Cystathionine-gamma-lyase (CSE) inhibitors US Patent US10227314 (2019)
- Chua, GNL; Wassarman, KL; Sun, H; Alp, JA; Jarczyk, EI; Kuzio, NJ; Bennett, MJ; Malachowsky, BG; Kruse, M; Kennedy, AJ Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett 10: 180-185 (2019)
- Abdelghani, A; A., CD; Anthony, D; Xavier, F; Shuhei, K; M., LS; Bing, L; G., NA; Alexander, P; A., VB; C., YE DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 WIPO WO2022098809 (2022)
- Leblond, B; Casagrande, A; Desire, L; Foucourt, A; Besson, T DYRK1 inhibitors and uses thereof US Patent US9446044 (2016)
- Bethel, PA; Gerhardt, S; Jones, EV; Kenny, PW; Karoutchi, GI; Morley, AD; Oldham, K; Rankine, N; Augustin, M; Krapp, S; Simader, H; Steinbacher, S Design of selective Cathepsin inhibitors. Bioorg Med Chem Lett 19: 4622-5 (2009)
- Tan, R; Zhang, W; Wang, Y; Zhao, X; Cheng, T; Lin, S; Wang, W Deuterated compounds as rock inhibitors US Patent US11485707 (2022)
- Lee, HY; Sohn, JH; Kwon, BM Development of tripeptidyl farnesyltransferase inhibitors. Bioorg Med Chem Lett 12: 1599-602 (2002)
- Lim, Y; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R Diacylglyceride O-acyltransferase 2 inhibitors US Patent US11787810 (2023)
- Boehm, M; Cabral, S; Dowling, MS; Futatsugi, K; Huard, K; Lee, EC; Londregan, AT; Polivkova, J; Price, DA; Li, Q Diacylglycerol acyl transferase 2 inhibitors US Patent US10071992 (2018)
- Shen, D; Dwyer, MP; Sinz, CJ; Wang, D; Stachel, SJ; Paone, DV; Forster, A; Berger, R; Chen, Y; Qian, Y; Xu, S; Hu, C Dihydropyrazolopyrimidinone compounds as PDE2 inhibitors US Patent US10174037 (2019)
- Claremon, DA; Dillard, LW; Dong, C; Fan, Y; Jia, L; Liu, Z; Lotesta, SD; Marcus, A; Singh, SB; Tice, CM; Yuan, J; Zhao, W; Zheng, Y; Zhuang, L Dihydropyrrolopyridine inhibitors of ROR-gamma US Patent US11535614 (2022)
- Choi, S; Song, KS; Lee, SH; Kim, MJ; Seo, HJ; Park, E; Kong, Y; Park, SO; Kang, H; Jung, ME; Lee, K; Kim, HJ; Lee, JS; Lee, MW; Kim, M; Hong, DH; Kang, M Diphenylmethane derivatives as SGLT2 inhibitors US Patent US9034921 (2015)
- Naganuma, K; Omura, A; Maekawara, N; Saitoh, M; Ohkawa, N; Kubota, T; Nagumo, H; Kodama, T; Takemura, M; Ohtsuka, Y; Nakamura, J; Tsujita, R; Kawasaki, K; Yokoi, H; Kawanishi, M Discovery of selective PDE4B inhibitors. Bioorg Med Chem Lett 19: 3174-6 (2009)
- Hunt, JA; Beresis, RT; Goulet, JL; Holmes, MA; Hong, XJ; Kovacs, E; Mills, SG; Ruzek, RD; Wong, F; Hermes, JD; Park, YW; Salowe, SP; Sonatore, LM; Wu, L; Woods, A; Zaller, DM; Sinclair, PJ Disubstituted pyrimidines as Lck inhibitors. Bioorg Med Chem Lett 19: 5440-3 (2009)
- Woo, LW; Bubert, C; Sutcliffe, OB; Smith, A; Chander, SK; Mahon, MF; Purohit, A; Reed, MJ; Potter, BV Dual aromatase-steroid sulfatase inhibitors. J Med Chem 50: 3540-60 (2007)
- Vandeusen, CL; Walts, AE; Or, YS EIF4E inhibitors and uses thereof US Patent US11753403 (2023)
- Haq, N; Niu, D; Petter, RC; Qiao, L; Singh, J; Zhu, Z ERK inhibitors and uses thereof US Patent US9796700 (2017)
- Kozak, KR; Prusakiewicz, JJ; Rowlinson, SW; Marnett, LJ Enantiospecific, selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 12: 1315-8 (2002)
- Makriyannis, A; Nikas, SP; Alapafuja, SO; Shukla, VG Fatty acid amide hydrolase inhibitors US Patent US9102622 (2015)
- Knight, ZA; Shokat, KM Features of selective kinase inhibitors. Chem Biol 12: 621-37 (2005)
- Liu, D; Zhang, M Furanone compounds as kinase inhibitors US Patent US9458140 (2016)
- Fatheree, PR; Brandt, GE; Smith, C; Sullivan, SD; Van Orden, LJ Fused imidazo-piperidine JAK inhibitors US Patent US11254669 (2022)
- Nara, SJ; Dzierba, CD; Macor, JE; Bronson, JJ; Ramkumar, R; Maishal, TK; Karatholuvhu, MS; Thangavel, S; Thiyagarajan, K Fused pyridines as kinase inhibitors US Patent US10174044 (2019)
- Di Francesco, ME; Jones, P; Heffernan, T; Hamilton, MM; Kang, Z; Soth, MJ; Burke, JP; Le, K; Carroll, CL; Palmer, WS; Lewis, R; McAfoos, T; Czako, B; Liu, G; Theroff, J; Herrera, Z; Yau, A GLS1 inhibitors for treating disease US Patent US11370786 (2022)
- Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A; Keding, SJ; Smith, DL Ghrelin 0-acyl transferase inhibitors US Patent US10227310 (2019)
- Galka, CS; Hembre, EJ; Honigschmidt, NA; Martinez-Grau, MA; Plaza, GR; Rubio, A Ghrelin O-acyl transferase inhibitors US Patent US10093651 (2018)
- McEachern, EJ; Vocadlo, DJ; Zhou, Y; Selnick, HG Glycosidase inhibitors and uses thereof US Patent US9522883 (2016)
- Wagner, FF; Hickman, D HDAC6 INHIBITORS AND USES THEREOF US Patent US20250179065 (2025)
- Hooker, J; Wang, C; Strebl-Bantillo, MG; Rokka, JK HDAC6 inhibitors and imaging agents US Patent US11890356 (2024)
- Kuo, Y; Huang, W; Chang, C HDAC8 inhibitors for treating cancer US Patent US11505523 (2022)
- HEINRICH, T; Gehrtz, P HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS US Patent US20250032625 (2025)
- DE LOMBAERT, S HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS US Patent US20250066318 (2025)
- Linney, ID; Ray, NC; Watson, MJ; Blaney, PM; Kern, OT; Osborne, S; Amber, M; Mpamhanga, C HETEROCYCLIC DERIVATIVES AS MALT1 INHIBITORS US Patent US20250136577 (2025)
- Zhong, W; Zhu, X; Feng, S; Wu, L; Huang, W; Liu, H; Liu, R; Wen, KX; Zhou, H HPK1 INHIBITORS AND USES THEREOF US Patent US20230339896 (2023)
- Hudson, AR; Govek, SP; Nagasawa, JY; Botrous, I; Smith, ND; Fasanya, KL HSD17B13 INHIBITORS AND USES THEREOF US Patent US20240034736 (2024)
- Adams, JA; Bechle, BM; Dutra, JK; Garnsey, MR; Hou, X; Lee, J; Nason, II, DM; O''Neil, SV; Rankic, DA; Wang, Y; Wright, AS; Zhang, L; Zhang, L; Edmonds, DJ HSD17B13 INHIBITORS AND/OR DEGRADERS US Patent US20240150334 (2024)
- Smythe, ML; Flanagan, JU Haematopoietic-prostaglandin D2 synthase inhibitors US Patent US9199976 (2015)
- Nelms, K; Schwartz, B; Jackson, C; Banwell, M; Hammond, E Heparanase inhibitors and use thereof US Patent US11718609 (2023)
- Bosanac, T; Bentzien, J; Burke, MJ; Fryer, RM; Larson, ET; Mao, W; McKibben, BP; Shen, Y; Soleymanzadeh, F; Tschantz, MA Heteroaromatic compounds as BTK inhibitors US Patent US9975882 (2018)
- Fleck, MT; Godbout, C; Koolman, HF Heteroaromatic compounds as Vanin inhibitors US Patent US11078182 (2021)
- Kargbo, RB Heterocyclic Amides as Kinase Inhibitors. ACS Med Chem Lett 9: 1160-1161 (2018)
- Pham, SM; Chakravarty, S; Kankanala, J; Chen, J; Miller, CP; Pettigrew, JD; Nayak, AK; Barde, A Heterocyclic compounds as BET inhibitors US Patent US11584756 (2023)
- Deng, Y; Zhu, L; Shipps, Jr., GW; Lo, S; Sun, B; Huang, X; Bienstock, C; Cooper, AB; Gao, X; Yao, X; Zhu, HY; Kelly, JM; Boga, SB; Alhassan, A; Tagat, JR; Mansoor, UF; Wilson, KJ; O'Boyle, BM; Daniels, MH; Schell, A; Siliphaivanh, P; Fischer, C Heterocyclic compounds as ERK inhibitors US Patent US8999957 (2015)
- He, C; Li, Z; Wu, L; Yao, W; Zhang, F Heterocyclic compounds as LSD1 inhibitors US Patent US11401272 (2022)
- Hallur, G; Duraiswamy, AJ; Purra, BR; Rao, NV; Rajagopal, S Heterocyclic compounds as pad inhibitors US Patent US11833156 (2023)
- Shepard, S; Ai, Y; Combs, AP; Falahatpisheh, N; Shao, L; Shvartsbart, A Heterocyclic derivatives as PI3K inhibitors US Patent US11078204 (2021)
- Di Francesco, ME; Jones, P; Carroll, CL; Cross, JB; Ramaswamy, SK; Johnson, MG; Lively, S; Lapointe, D Heterocyclic inhibitors of ATR kinase US Patent US11434233 (2022)
- Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent US10329303 (2019)
- Heymach, J; Robichaux, J; Nilsson, M; Jones, P; Cross, J; Theroff, J Heterocyclic inhibitors of tyrosine kinase US Patent US11365189 (2022)
- Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Highly selective tripeptide thrombin inhibitors. J Med Chem 36: 314-9 (1993)
- Brown, LE; Huang, DS; Cowen, LE; Whitesell, L; Marcyk, P Hsp90 inhibitors and uses thereof US Patent US11312722 (2022)
- HUDKINS, RL; BENSEN, DC INDAZOLE COMPOUNDS AS KINASE INHIBITORS US Patent US20240109865 (2024)
- van Leyen, K; Zheng, Y; Holman, T; Johnson, G; Herr, RJ INHIBITORS OF 12/15-LIPOXYGENASE US Patent US20240336642 (2024)
- TYHONAS, J; KANOUNI, T; COX, JM; KANIA, RS; OUYANG, XS INHIBITORS OF CDK4/6 KINASE US Patent US20250163063 (2025)
- TONKS, N; GAUSS, C; VENKATARAMANI, P; JOSHUA-TOR, L; ELKAYAM, E; ABED, YA; CHENG, KF; ALTITI, A; ORFI, L; SZABADKAI, I; SZOKOL, B; HORVATH, Z INHIBITORS OF DYRK AND PIM US Patent US20240199561 (2024)
- Abagyan, R; Parchinsky, VZ; Khvat, A; Ivachtchenko, AV; Savchuk, N INHIBITORS OF MENIN-MLL INTERACTION US Patent US20250163061 (2025)
- Veal, JM; Stafford, JA; Karanewsky, DS; Herath, S INHIBITORS OF QPCTL AND QPCT US Patent US20240101544 (2024)
- SACCHETTINI, J; ACHARYA, A; FLORES, A; KRIEGER, I; PARAI, M; ZHOU, N; BAM, R; JAISWAL, PK; TANG, S; BIAN, X; SHI, Z INHIBITORS OF SARS-COV-2 US Patent US20250074907 (2025)
- Mathavan, I; Liu, LJ; Robinson, SW; El-Sakkary, N; Elatico, AJJ; Gomez, D; Nellas, R; Owens, RJ; Zuercher, W; Navratilova, I; Caffrey, CR; Beis, K Identification of Inhibitors of the ACS Med Chem Lett 13: 1715-1722 (2022)
- Siebeneicher, H; Bauser, M; Buchmann, B; Heisler, I; Müller, T; Neuhaus, R; Rehwinkel, H; Telser, J; Zorn, L Identification of novel GLUT inhibitors. Bioorg Med Chem Lett 26: 1732-7 (2016)
- Mevellec, LA; Meerpoel, L; Coupa, S; Poncelet, VS; Pilatte, IN; Pasquier, ET; Berthelot, DJ; Querolle, OA; Meyer, C; Angibaud, PR; Demestre, CG; Mercey, GJ Imidazopyridazine derivatives as PI3KB inhibitors US Patent US10087187 (2018)
- Bärfacker, L; Scott, W; Hägebarth, A; Ince, S; Rehwinkel, H; Politz, O; Neuhaus, R; Briem, H; Bömer, U Imidazopyridazines as Akt kinase inhibitors US Patent US9604989 (2017)
- Cogan, DA; Bettigole, S; Van Berkom, L; Nieczypor, P; Su, M; Folmer, R Imino sulfanone inhibitors of ENPP1 US Patent US11780849 (2023)
- Malathong, V; Mali, VR; McMurtrie, DJ; Punna, S; Roth, HS; Singh, R; Yang, J; Zhang, P Indanes as PD-L1 inhibitors US Patent US11872217 (2024)
- Siu, T; Altman, MD; Andresen, BM; Liu, J; Kozlowski, J; Boga, SB; Yu, Y; Anand, R; Cai, J; Wang, D; Liu, S Indazole and azaindazole Btk inhibitors US Patent US10246457 (2019)
- Guo, J; Dzierba, CD; Hart, AC; Macor, JE; Pitts, WJ Indazole carboxamides as kinase inhibitors US Patent US12084426 (2024)
- Cai, J; Crespo, A; Debenham, J; Du, X; Liu, P; Liu, R; Madsen-Duggan, CB; Quan, W; Sinz, C; Wang, L Inhibitors of HIF prolyl hydroxylase US Patent US10208060 (2019)
- Vaccaro, W; Amore, C; Berger, J; Burrier, R; Clader, J; Davis, H; Domalski, M; Fevig, T; Salisbury, B; Sher, R Inhibitors of acyl CoA:cholesterol acyltransferase. J Med Chem 39: 1704-19 (1996)
- Illig, CR; Ballentine, SK; Chen, J; Desjarlais, RL; Meegalla, SK; Wall, M; Wilson, K Inhibitors of c-fms kinase US Patent US9221797 (2015)
- Kanouni, T; Arnold, LD; Kaldor, SW; Murphy, EA; Tyhonas, J Inhibitors of cyclin-dependent kinases US Patent US11390618 (2022)
- Pujala, B; Panpatil, D; Bernales, S; Belmar, S; Ureta Díaz, GA Inhibitors of fibroblast activation protein US Patent US11504364 (2022)
- Pinkerton, AB; Hassig, CA; Jackson, MR; Ardecky, RJ; Pass, I Inhibitors of glucocorticoid receptor translocation US Patent US10272074 (2019)
- Bjornson, K; Canales, E; Cottell, JJ; Karki, KK; Katana, AA; Kato, D; Kobayashi, T; Link, JO; Martinez, R; Phillips, BW; Pyun, H; Sangi, M; Schrier, AJ; Siegel, D; Taylor, JG; Tran, CV; Trejo Martin, TA; Vivian, RW; Yang, Z; Zablocki, J; Zipfel, S Inhibitors of hepatitis C virus US Patent US10335409 (2019)
- Roinestad, K; Guilford, W; Kirkland, T; Bhatt, L; Springman, E Inhibitors of leukotriene A4 hydrolase US Patent US10202362 (2019)
- Seitz, SP; Markwalder, JA; Purandare, AV Inhibitors of lysine methyl transferase US Patent US9822103 (2017)
- Hoffman, CS; Ceyhan, O Inhibitors of phosphodiesterase 11 (PDE11) US Patent US9173884 (2015)
- Zhang, Z; Zhang, S Inhibitors of protein tyrosine phosphatases US Patent US9217012 (2015)
- Banerjee, M; Middya, S; Shrivastava, R; Raina, S; Surya, A; Yadav, DB; Yadav, VK; Kapoor, KK; Venkatesan, A; Smith, RA; Thompson, SK Inhibitors of the kynurenine pathway US Patent US10294212 (2019)
- Rosse, G Irreversible inhibitors of cysteine proteases. ACS Med Chem Lett 4: 163-4 (2013)
- Brown, HA; Lindsley, CW; Waterson, AG; Scott, SA Isoform selective phospholipase D inhibitors US Patent US9127005 (2015)
- Claremon, DA; Dillard, LW; Dong, C; Fan, Y; Jia, L; Lotesta, SD; Marcus, A; Singh, SB; Tice, CM; Yuan, J; Zhao, W; Zheng, Y; Zhuang, L Isoindoline inhibitors of ROR-gamma US Patent US9845308 (2017)
- Berger, R; Blizzard, TA; Campbell, BT; Chen, HY; Debenham, JS; Dewnani, SV; Dubois, B; Gude, C; Guo, ZZ; Harper, B; Hu, Z; Lin, S; Liu, P; Wang, M; Ujjainwalla, F; Xu, J; Xu, L; Zhang, R Isoquinoline derivatives as MGAT2 inhibitors US Patent US10065945 (2018)
- Chan, B; Drobnick, J; Gazzard, L; Heffron, T; Liang, J; Malhotra, S; Mendonca, R; Rajapaksa, N; Stivala, C; Tellis, J; Wang, W; Wei, B; Zhou, A; Cartwright, MW; Lainchbury, M; Gancia, E; Seward, E; Madin, A; Favor, D; Fong, KC; Hu, Y; Good, A Isoquinolines as inhibitors of HPK1 US Patent US11566003 (2023)
- Konradi, AW; Galemmo, Jr., RA; Dominy, SS; Lynch, CC; Holsinger, LJ Ketone inhibitors of lysine gingipain US Patent US11325884 (2022)
- De Vicente Fidalgo, J; Estrada, AA; Feng, JA; Fox, B; Francini, CM; Hale, CR; Hu, C; Leslie, CP; Osipov, M; Serra, E; Sweeney, ZK; Thottumkara, A Kinase inhibitors and uses thereof US Patent US11203600 (2021)
- Jayatilake, GS; Jayasuriya, H; Lee, ES; Koonchanok, NM; Geahlen, RL; Ashendel, CL; McLaughlin, JL; Chang, CJ Kinase inhibitors from Polygonum cuspidatum. J Nat Prod 56: 1805-10 (1993)
- Green, J; Charifson, P; Botella, GM; Griffin, A LONP1 INHIBITORS, USES AND METHODS US Patent US20250059213 (2025)
- Glunz, PW; Sitkoff, DF; Bodas, MS; Yadav, ND; Patil, S; Maddu Rao, PS Lactams as inhibitors of rock US Patent US10112929 (2018)
- Patel, JZ; Ahenkorah, S; Vaara, M; Staszewski, M; Adams, Y; Laitinen, T; Navia-Paldanius, D; Parkkari, T; Savinainen, JR; Walczynski, K; Laitinen, JT; Nevalainen, TJ Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett 25: 1436-42 (2015)
- Wiles, JA; Gadhachanda, VR MACROCYCLE COMPLEMENT FACTOR B INHIBITORS US Patent US20240182503 (2024)
- LIN, G; NATHAN, C; KIRKMAN, L; ZHAN, W; MORGAN, T; SATO, K; HARA, R; KAWASAKI, M; IMAEDA, T; TOITA, A; OKAMOTO, R; YUKAWA, T; ASO, K; WONG, T; GINN, JD; FOLEY, MA MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS US Patent US20240043470 (2024)
- Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 (2019)
- CASTRO, AC; BURKE, MJ; WYNN, TA; RUPPEL, SK; SANTILLANA SOTO, SL; HAINES, E; XU, L; ZAVIDIJ, O MEK INHIBITORS AND USES THEREOF US Patent US20230382863 (2023)
- Hu, X; Qiao, L; Seletsky, B; Patton, M; Cao, M; van der Mei, F; Miao, G; McDonald, I; Dzierba, C MK2 INHIBITORS AND USES THEREOF US Patent US20240190890 (2024)
- Trzoss, L; Dong, Q; Kaldor, SW; Hoffman, RL MK2 inhibitors and uses thereof US Patent US11680056 (2023)
- Harvey, DM; Campbell, JE; Duncan, KW MYST family histone acetyltransferase inhibitors US Patent US11685732 (2023)
- Corte, JR; Fang, T; Decicco, CP; Pinto, DJ; Rossi, KA; Hu, Z; Jeon, Y; Quan, ML; Smallheer, JM; Wang, Y; Yang, W Macrocycles as factor XIa inhibitors US Patent US9802939 (2017)
- Iyamu, ID; Huang, R Mechanisms and inhibitors of nicotinamide RSC Med Chem 12: 1254-1261 (2021)
- Chen, Y Methods of identifying SENP1 inhibitors US Patent US9791447 (2017)
- Minidis, A; Rahm, F; Viklund, J Mono-fluoro beta-secretase inhibitors US Patent US9650336 (2017)
- BLOM, PM; HOUSSEMAN, CG; DAUGAN, A; DUMOULIN, A; LAUGEOIS, M; DENIS, A; FAUCHER, N; BOTEZ, I; LE TIRAN, A; CHRISTENSEN, K; LAMOTTE, Y NEW MACROCYCLIC LRRK2 KINASE INHIBITORS US Patent US20230357269 (2023)
- Chan, B; Daniels, B; Drobnick, J; Gazzard, L; Heffron, T; Huestis, M; Liang, J; Malhotra, S; Mendonca, R; Rajapaksa, N; Siu, M; Stivala, C; Tellis, J; Wang, W; Wei, B; Zhou, A; Cartwright, MW; Gancia, E; Jones, G; Lainchbury, M; Madin, A; Seward, E; Favor, D; Fong, KC; Good, A; Hu, Y; Hu, B; Lu, A Naphthyridines as inhibitors of HPK1 US Patent US11034692 (2021)
- Arrington, KL; Burgey, C; Gilfillan, R; Han, Y; Patel, M; Li, CS; Luo, Y; Lei, Z Non-nucleoside reverse transcriptase inhibitors US Patent US9718819 (2017)
- Ghosh, AK Nonpeptide HIV-1 protease inhibitors US Patent US9085571 (2015)
- Castro, AC; Dang, LC; Soucy, F; Grenier, L; Mazdiyasni, H; Hottelet, M; Parent, L; Pien, C; Palombella, V; Adams, J Novel IKK inhibitors: beta-carbolines. Bioorg Med Chem Lett 13: 2419-22 (2003)
- Liu, F; Wang, B; Liu, Y; Shi, W; Tang, X; Wang, X; Hu, Z; Zhang, Y; Guo, Y; Chang, X; He, X; Xu, H; He, Y Novel TYK2 Inhibitors with an ACS Med Chem Lett 13: 1730-1738 (2022)
- Schmeck, C; Gielen-Haertwig, H; Vakalopoulos, A; Bischoff, H; Li, V; Wirtz, G; Weber, O Novel tetrahydrochinoline derived CETP inhibitors. Bioorg Med Chem Lett 20: 1740-3 (2010)
- Kotian, PL; Babu, YS; Zhang, W; Lu, P; Spaulding, AE; Lv, W; Dang, Z; Raman, K ORAL COMPLEMENT FACTOR D INHIBITORS US Patent US20250186391 (2025)
- Trzoss, L; Dong, Q; Kaldor, SW PARP1 inhibitors and uses thereof US Patent US11591331 (2023)
- NDUBAKU, C; MOORE, JT; GIBBONS, PA; CHANG, JH; ROMERO, FA; DU, X; KAWAI, H; CIBLAT, S; WANG, H; ALBERT, V; CONSTANTINEAU-FORGET, L; SILVA, H; POLAT, DE; NAYYAR, A; SHORE, DG; WU, K; TAN, J POLO LIKE KINASE 4 INHIBITORS US Patent US20230365537 (2023)
- Duncan, KW; Chesworth, R; Boriack-Sjodin, PA; Munchhof, MJ PRMT5 inhibitors and uses thereof US Patent US10118918 (2018)
- Tsou, LK; Hung, M; Chen, CW; Hsieh, M; Chang, Y; Chuang, LM PTGR2 INHIBITORS AND THEIR USE US Patent US20230279008 (2023)
- GIORDANETTO, F; JENSEN, M; JOGINI, V; SNOW, RJ PYRIDAZINONE COMPOUNDS AS TRPA1 INHIBITORS US Patent US20250154139 (2025)
- CARZANIGA, L; RANCATI, F; RIZZI, A; GHIDINI, E; IOTTI, N; MAZZUCATO, R; LEVANTO, S; WHITTAKER, BP PYRROLIDINE DERIVATIVES AS DDRS INHIBITORS US Patent US20240425482 (2024)
- Frick, JM; Garnsey, MR; Gerstenberger, BS; Hou, X; Korczynska, M; Lee, AA; Nguyen, LT; Reilly, U; Robinson, MC; Taylor, AP; Vargo, TR; Zhang, L Papain-like protease (PLpro) inhibitors US Patent US20240245673 (2024)
- Orwat, MJ; Pinto, DJ Phenylacetamides as inhibitors of rock US Patent US11306081 (2022)
- Vandeusen, CL; Weiberth, FJ; Gill, HS; Lee, G; Hillegass, A Phenyloxadiazole derivatives as PGDS inhibitors US Patent US9469627 (2016)
- Landry, DW; Deng, S; Arancio, O; Fiorito, J; Wasmuth, A Phosphodiesterase inhibitors and uses thereof US Patent US10626113 (2020)
- Benz, J; Grether, U; Hornsperger, B; Kuhn, B; Richter, H; Kocer, B; O''Hara, F; Ritter, M; Tsuchiya, S; Collin, L; Johnson, SE; Bell, C Piperazine derivatives as MAGL inhibitors US Patent US11390610 (2022)
- Abdel-Aziz, AA; Morsy, AS; Attia, SM Piperidine compounds as PDE5 inhibitors US Patent US12139461 (2024)
- Wang, S; Aguilar, A; Xu, S; Huang, L; Stuckey, J; Xu, T Piperidines as covalent menin inhibitors US Patent US11045448 (2021)
- Blackaby, WP; Thomas, EJ; Hardick, DJ; Shepherd, J; Brookfield, FA; Bubert, C; Ridgill, MP Polyheterocyclic compounds as METTL3 inhibitors US Patent US11725010 (2023)
- Barrows, RD; Jeffries, DE; Vishe, M; Tukachinsky, H; Zheng, SL; Li, F; Ma, Z; Li, X; Jin, S; Song, H; Zhang, R; Zhang, S; Ni, J; Luan, H; Wen, L; Rongshan, Y; Ying, C; Shair, MD Potent Uncompetitive Inhibitors of Nicotinamide J Med Chem 65: 14642-14654 (2022)
- Bonafoux, D; Davis, HM; Frank, KE; Friedman, MM; Herold, JM; Hoemann, MZ; Huntley, R; Osuma, A; Sheppard, G; Somal, GK; Van Camp, J; Van Epps, SA; Vasudevan, A; Wallace, GA; Wang, L; Wang, L; Wang, Z; Wilson, NS; Xu, X Primary carboxamides as BTK inhibitors US Patent US9567339 (2017)
- Charrier, J; Studley, J; Pierard, FY; Durrant, SJ; Littler, BJ; Hughes, RM; Siesel, DA; Angell, P; Urbina, A; Shi, Y Processes for preparing ATR inhibitors US Patent US10208027 (2019)
- Jin, X; Yu, R; Wang, X; Proud, CG; Jiang, T Progress in developing MNK inhibitors. Eur J Med Chem 219: (2021)
- Chen, W; Jia, ZJ; Loury, DJ Purinone compounds as kinase inhibitors US Patent US9637487 (2017)
- Forns, P; Esteve, C; Taboada, L; Alonso, JA; Orellana, A; Maldonado, M; Carreño, C; Ramis, I; López, M; Miralpeix, M; Vidal, B Pyrazine-based Syk kinase inhibitors. Bioorg Med Chem Lett 22: 2784-8 (2012)
- Guckian, K; Carter, MB; Lin, EY; Choi, M; Sun, L; Boriack-Sjodin, PA; Chuaqui, C; Lane, B; Cheung, K; Ling, L; Lee, WC Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett 20: 326-9 (2010)
- Schmidt, B; Scheufler, C; Volz, J; Feth, M; Hummel, R; Hatzelmann, A; Zitt, C; Wohlsen, A; Marx, D; Kley, H; Ockert, D; Heuser, A; Christiaans, JA; Sterk, GJ; Menge, WM Pyrazolone derivatives as PDE4 inhibitors US Patent US8865745 (2014)
- Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrazolopyrimidine inhibitors of IRAK4 activity US Patent US10329294 (2019)
- Cariou, CA; Charron, CE; Fordyce, EA; Hamza, D; Fyfe, MC; Ito, K; King-Underwood, J; Murray, PJ; Onions, ST; Thom, SM; Watson, HT; Williams, JG Pyrazolyl-ureas as kinase inhibitors US Patent US9701670 (2017)
- Bastian, JA; Clayton, JR; Coates, DA; Sall, DJ; Woods, TA Pyrazolylaminobenzimidazole derivatives as JAK inhibitors US Patent US10323019 (2019)
- Xu, Q; Song, Y; Pandey, A Pyridazine compounds as JAK inhibitors US Patent US9834548 (2017)
- Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinones as DAAO enzyme inhibitors US Patent US9750748 (2017)
- Altman, MD; Di Francesco, ME; Haidle, AM; Otte, RD; Ellis, JM; Childers, KK; Northrup, AB; Wang, L Pyridyl aminopyridines as Syk inhibitors US Patent US9120785 (2015)
- Boral, S; Malone, TC; Wang, S Pyridyl benzothiophenes as kinase inhibitors US Patent US9868726 (2018)
- Dilger, AK; Corte, JR; De Lucca, I; Fang, T; Yang, W; Wang, Y; Pabbisetty, KB; Ewing, WR; Zhu, Y; Wexler, RR; Pinto, DJ; Orwat, MJ; Smith, II, LM Pyrimidinones as factor XIa inhibitors US Patent US9453018 (2016)
- Braun, A; Crespin, O; Foricher, Y; Marciniak, G; Muzet, N; Nicolai, E; Pascal, C; Vivet, B; Viviani, F Pyrimidooxazocine derivatives as mTOR-inhibitors US Patent US9120812 (2015)
- Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolopyridazine inhibitors of IRAK4 activity US Patent US10040798 (2018)
- Brazeau, JF; Rosse, G Pyrrolopyrimidine Analogues as MKNK Inhibitors. ACS Med Chem Lett 6: 9-10 (2015)
- Li, Y; Burns, DM; Feng, H; Glenn, J; He, C; Huang, T; Mei, S; Pan, J; Wang, X; Ye, Y Pyrrolopyrimidine derivatives as TAM inhibitors US Patent US10053465 (2018)
- Li, Y; Wang, X; He, C Pyrrolotriazine compounds as TAM inhibitors US Patent US11591338 (2023)
- Li, Y; Wang, X; He, C Pyrrolotriazine compounds as tam inhibitors US Patent US9981975 (2018)
- Lim, J; Altman, MD; Brubaker, JD; Gibeau, CR Pyrrolotriazine inhibitors of IRAK4 activity US Patent US10329295 (2019)
- Erra Sola, M; Carrascal Riera, M; Taltavull Moll, J; Caturla Javaloyes, JF; Bernal Anchuela, FJ; Pages Santacana, LM; Mir Cepeda, M; Casals Coll, G; Hernandez Olasagarre, MB Pyrrolotriazinone derivatives as PI3K inhibitors US Patent US9388189 (2016)
- Pettersen, D; Davidsson, Ö; Whatling, C Recent advances for FLAP inhibitors. Bioorg Med Chem Lett 25: 2607-12 (2015)
- Chen, Y; Zhou, X Research progress of mTOR inhibitors. Eur J Med Chem 208: (2020)
- Khandelwal, A; Crowley, VM; Blagg, BSJ Resorcinol-Based Grp94-Selective Inhibitors. ACS Med Chem Lett 8: 1013-1018 (2017)
- Patel, DV; Ryono, DE Retro-Inverso Tripeptide Renin Inhibitors Bioorg Med Chem Lett 2: 1089-1092 (1992)
- Ammann, SE; Cai, X; Canales, EY; Chang, WK; Chin, GF; Kinfe, HH; Lazerwith, SE; McKinley, JL; Mish, MR; Naduthambi, D; Perry, JK; Rodriguez, KX; Schroeder, SD; Swank, CJ; Van Veldhuizen, JJ SARS-COV2 MAIN PROTEASE INHIBITORS US Patent US20240116946 (2024)
- Wang, K; Hu, Z; Zhang, F; Huang, W; Feng, T; Xiao, F; Zhong, W SOS1 INHIBITORS AND USES THEREOF US Patent US20240051956 (2024)
- Ren, Z; Sun, X; Xu, Q SSAO inhibitors and use thereof US Patent US11472769 (2022)
- BUCHSTALLER, H; KUHN, D; COLLINS, I; MATTHEWS, T; LANZ, J; CALDWELL, J; COLOMBANO, G SUBSTITUTED HETEROCYCLES AS HSET INHIBITORS US Patent US20250084074 (2025)
- HOFFMAN, RL; VA, PJ; PINCHMAN, JR; DONG, Q; KALDOR, SW SUBSTITUTED PYRIDINES AS PARP1 INHIBITORS US Patent US20230348473 (2023)
- Thomson, CG; Duncan, K; Fletcher, SR; Huscroft, IT; Pillai, G; Raubo, P; Smith, AJ; Stead, D Sarcosine based indandione hGlyT1 inhibitors. Bioorg Med Chem Lett 16: 1388-91 (2006)
- Blagg, BS; Crowley, VM Second generation GRP94-selective inhibitors US Patent US11028041 (2021)
- van Duzer, JH; Mazitschek, R Selective HDAC1 and HDAC2 inhibitors US Patent US9145412 (2015)
- Sotomayor, EM; Bergman, J; Kozikowski, A; Woan, KV; Villagra, AV Selective histone deactylase 6 inhibitors US Patent US9409858 (2016)
- Kaniskan, HÜ; Konze, KD; Jin, J Selective inhibitors of protein methyltransferases. J Med Chem 58: 1596-629 (2015)
- Hammock, BD; Hwang, SH; Wecksler, AT; Morisseau, C Sorafenib derivatives as sEH inhibitors US Patent US9029401 (2015)
- Quattropani, A; Kulkarni, SS; Rakesh, P; Giri, AG Spiro compounds as glycosidase inhibitors US Patent US11731972 (2023)
- Sarges, R; Schnur, RC; Belletire, JL; Peterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem 31: 230-43 (1988)
- Schnur, RC; Sarges, R; Peterson, MJ Spiro oxazolidinedione aldose reductase inhibitors. J Med Chem 25: 1451-4 (1983)
- Vokits, BP; Shaw, SA Spiroheptanyl hydantoins as rock inhibitors US Patent US11447487 (2022)
- Hendra, R; Salib, MN; Molinski, TF Spiroisoxazoline Inhibitors of Acetylcholinesterase from J Nat Prod 85: 2207-2216 (2022)
- Liu, P; Miller, CA; Yu, M; Zhang, Z; Ruppel, S; Padyana, AK Substituted benzamides as RIPK2 inhibitors US Patent US10138241 (2018)
- Anand, R; Colandrea, VJ; Reiter, M; Vachal, P; Zwicker, A; Wilson, JE; Zhang, F; Zhao, K Substituted benzopiperazines as CETP inhibitors US Patent US9126976 (2015)
- Ritzen, A; Langgard, M; Kehler, J; Nielsen, J; Kilburn, JP; Farah, MM Substituted imidazoles as PDE10A inhibitors US Patent US9592230 (2017)
- Terstiege, I; Schiesser, S; Xue, Y; Chang, H; Berggren, AI Substituted indazoles as IRAK4 inhibitors US Patent US11866405 (2024)
- Lee, T; Tarr, JC; Jeon, K; Salovich, JM; Shaw, S; Veerasamy, N; Kim, K; Christov, PP; Olejniczak, ET; Zhao, B; Fesik, SW; Bian, Z Substituted indole Mcl-1 inhibitors US Patent US11596639 (2023)
- Glunz, PW; Zou, Y; Quan, ML Substituted phthalazinones as rock inhibitors US Patent US9221767 (2015)
- Dai, G; Xiao, K Substituted piperazines as BTK inhibitors US Patent US11655254 (2023)
- Zhang, C; Liao, Y; Wang, J; Zhu, G; Ye, F; Tang, P; Chen, X; Huang, Z; Wu, S; Li, Y; Yan, P Substituted piperidines as BTK inhibitors US Patent US11542266 (2023)
- Ma, Y; Lahue, BR; Shipps, GW; Brookes, J; Wang, Y Substituted piperidines as HDM2 inhibitors. Bioorg Med Chem Lett 24: 1026-30 (2014)
- Kim, IW; Kim, NY; Jeong, SH; Kim, B; Lee, JH Substituted piperidines as kinase inhibitors US Patent US11407754 (2022)
- Kim, J; Choi, J; Park, S; Kim, HS; Jung, D; Koh, J; Kim, S; Lee, J Substituted pyrazoles as LRRK2 inhibitors US Patent US11370796 (2022)
- Zhang, D Substituted pyrazolopyrimidines as kinases inhibitors US Patent US9694011 (2017)
- Benowitz, AB; Fosbenner, DT; King, BW; Romeril, SP Substituted pyridines as DNMT1 inhibitors US Patent US11771711 (2023)
- Hoffman, RL; Va, PJ; Pinchman, JR; Dong, Q; Kaldor, SW Substituted pyridines as PARP1 inhibitors US Patent US11795173 (2023)
- Estrada, AA; Feng, JA; Lyssikatos, JP; Sweeney, ZK; de Vicente Fidalgo, J Substituted pyrimidines as LRKK2 inhibitors US Patent US11028080 (2021)
- Li, X Substituted pyrrolopyridines as ATR inhibitors US Patent US11236089 (2022)
- Jacobsen, EJ; Anderson, DR; Blinn, JR; Mukherjee, P; Changelian, P; Xu, C Substituted pyrrolopyridines as JAK inhibitors US Patent US11420966 (2022)
- Dinsmore, C; Fradera Llinas, FX; Kudale, AA; Machacek, M; Reutershan, MH; Thompson, CF; Trotter, BW; Yang, L; Altman, MD; Bogen, SL; Doll, RJ; Voss, ME Substituted pyrrolopyrimidines as HDM2 inhibitors US Patent US9637493 (2017)
- Babiss, L; Clark, M; Keefe, AD; Mulvihill, MJ; Ni, H; Renzetti, L; Ruebsam, F; Wang, C; Xie, Z; Zhang, Y Substituted spirocyclic inhibitors of autotaxin US Patent US10233182 (2019)
- Gardner, DS; Duncia, JV; Santella, JB Substituted thienopyrroles as PAD4 inhibitors US Patent US11981680 (2024)
- Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Zubov, D; Schamberger, J Substituted uracils as chymase inhibitors US Patent US9695131 (2017)
- Sokolsky, A; Winterton, S; Wu, L; Yao, W; Ye, M; Chen, Y; Favata, M; Lo, Y Sulfonylamide compounds as CDK2 inhibitors US Patent US11919904 (2024)
- Scholz, TH; Sondey, JM; Randall, WC; Schwam, H; Thompson, WJ; Mallorga, PJ; Sugrue, MF; Graham, SL Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase. J Med Chem 36: 2134-41 (1993)
- Castro, AC TEAD inhibitors and uses thereof US Patent US11458149 (2022)
- Hummel, J; Shi, S; Wang, X TETRACYCLIC COMPOUNDS AS DGK INHIBITORS US Patent US20240025900 (2024)
- Guanglin, L; Jie, C; Diane, DC; B., FD; Junqing, G; C., HA; Xirui, H; E., MM; Reiser, PM; Jianliang, S; H., SS; Lee, VB; Yong-Jin, W; Zili, X; G., YM TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS WIPO WO2022086828 (2022)
- Han, H; Zhao, L; Yao, W; Wang, X TRIAZOLOPYRIMIDINES AS A2A / A2B INHIBITORS US Patent US20250034153 (2025)
- ZHENG, S; DENG, W; CAMPOS, SA; YANG, Y; TIAN, Z; ZHENG, Q; WU, G; ZHAO, Z; LI, L; FU, J; ZHAO, S TRICYCLIC COMPOUNDS AS EGFR INHIBITORS US Patent US20240034743 (2024)
- Masse, CE; Greenwood, JR; Romero, DL; Harriman, GC; Wester, RT; Shelley, M; Kennedy-Smith, JJ; Dahlgren, M; Mondal, S; Robinson, S TYK2 inhibitors and uses thereof US Patent US11434240 (2022)
- Waghorn, PA; Jackson, MR; Gouverneur, V; Vallis, KA Targeting telomerase with radiolabeled inhibitors. Eur J Med Chem 125: 117-129 (2017)
- Liu, J; Kozlowski, JA; Andresen, BM; Boga, SB; Gao, X; Guiadeen, DG; Cai, J; Liu, S; Wang, D; Wu, H; Yang, C Tertiary alcohol imidazopyrazine BTK inhibitors US Patent US10208047 (2019)
- Fleck, MT; Binder, FP; Willwacher, J Tetrazole derivatives as TRPA1 inhibitors US Patent US11891403 (2024)
- Ahmad, S Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors US Patent US11479538 (2022)
- Claremon, DA; Dillard, LW; Dong, C; Fan, Y; Jia, L; Lotesta, SD; Marcus, A; Singh, SB; Tice, CM; Yuan, J; Zhao, W; Zheng, Y; Zhuang, L Thiazolopyrrolidine inhibitors of ROR- γ US Patent US9868748 (2018)
- Lim, J; Altman, MD; Gibeau, CR Thienopyrazine inhibitors of IRAK4 activity US Patent US10040802 (2018)
- Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent US10239876 (2019)
- Schindler, R; Lankau, H; Höfgen, N; Egerland, U; Langen, B; Dost, R; Ward, S Triazoles as NR2B receptor inhibitors US Patent US9981950 (2018)
- Flohr, A; Groebke Zbinden, K; Kuhn, B; Lerner, C; Rudolph, M; Schaffhauser, H Triazolo compounds as PDE10 inhibitors US Patent US9394311 (2016)
- Peterson, RT; Asnani, A; Liu, Y; Zheng, B; Wang, Y Tricyclic compounds as Cyp1 inhibitors US Patent US11396516 (2022)
- McCammant, MS; Styduhar, E; Vechorkin, O; Swyka, R; Yao, W Tricyclic heterocycles as FGFR inhibitors US Patent US11897891 (2024)
- Kane, Jr., JL; Matthews, G; Metz, M; Kothe, M; Liu, J; Scholte, A Tropomyosin-related kinase (TRK) inhibitors US Patent US11406644 (2022)
- Kane, Jr., JL; Matthews, G; Metz, M; Kothe, M; Liu, J; Scholte, A Tropomyosin-related kinase (Trk) inhibitors US Patent US10166239 (2019)
- ROMERO, DL; LEE, AD; BEHROUZ, B; FRITZEN, JR., EL USP30 INHIBITORS AND USES THEREOF US Patent US20250162989 (2025)
- Romero, DL; Johnson, MG; Lee, AD; Behrouz, B; Fritzen, Jr., EL USP30 inhibitors and uses thereof US Patent US11845724 (2023)