Query String: gamma-radiation paclitaxel
- peroxisome proliferator-activated receptor gamma (ppar gamma)
- gamma secretase
- gamma-cystathionase
- gamma-secretase
- ppar-gamma
- rar-gamma
- gamma-aminobutyric acid receptor subunit alpha-1/gamma-2
- dag kinase gamma
- g gamma-i
- gamma hydroxybutyric, ghb
- gamma-carbonic anhydrase
- gamma-glutamylcysteine synthetase
- gmp-pde gamma
- p38 delta/gamma
- ppar alpha/gamma
- gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-1
- gamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-4/beta-3/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-1
- gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2
- gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2
- akap-7 isoform gamma
- dna-pk/ p110-gamma
- interferon gamma receptor 1
- interferon gamma-inducing factor
- nuclear receptor ror-gamma
- phospholipase c, gamma 1
- phospholipase c-gamma-1
- phospholipase c-gamma-2
- pi3k-alpha/ p110-gamma
- retinoic acid receptor gamma
- retinoic acid receptor, gamma
- gamma-secretase subunit aph-1a/gamma-secretase subunit aph-1b/gamma-secretase subunit pen-2/nicastrin/presenilin-1/presenilin-2
- 14-3-3 protein gamma
- cam kinase ii delta/gamma
- casein kinase i gamma 2
- gaba receptor gamma-1 subunit
- gamma carbonic anhydrase family protein
- gamma-amino-n-butyrate transaminase
- gamma-secretase subunit pen-2
- nuclear receptor ror-gamma (rorc)
- peroxisome proliferator-activated receptor gamma
- phosphoinositide 3-kinase (pi3k), gamma
- phosphoinositide 3-kinase-c2-gamma
- protein-glutamine gamma-glutamyltransferase 2
- protein-glutamine gamma-glutamyltransferase 6
- protein-glutamine gamma-glutamyltransferase e
- protein-glutamine gamma-glutamyltransferase k
- protein-glutamine gamma-glutamyltransferase z
- protein-glutamine gamma-glutamyltransferase, liver
- retinoic acid receptor rxr-gamma
- retinoic acid receptors gamma / alpha
- retinoid-related orphan receptor-gamma
- urease subunit alpha/beta/gamma
- gamma-secretase subunit aph-1a/gamma-secretase subunit pen-2/nicastrin [34-709]/presenilin-1
- acetylcholine receptor; alpha1/beta1/delta/gamma
- casein kinase i gamma 1 isoform
- nuclear receptor ror-gamma [238-497]
- nuclear receptor ror-gamma [258-518]
- peroxisome proliferator-activated receptor gamma (pparg)
- receptor-type tyrosine-protein phosphatase gamma
- retinoic acid receptor gamma [183-417]
- retinoic acid receptor rxr-alpha/gamma
- retinoid-related orphan receptor-gamma (rorgt)
- serine/threonine-protein kinase mrck gamma
- urease subunit alpha [f36l]/beta/gamma
- gamma-aminobutyric acid receptor subunit alpha-1 [g200c]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [s205c]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [t206c]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [v202c]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [v211c]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-3 [26-473]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-3 [26-473]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-3 [29-492]/beta-3 [26-473]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-4 [36-554]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-2 [26-512]/gamma-2 [40-467]
- gamma-aminobutyric acid receptor subunit alpha-6 [20-453]/beta-3 [26-473]/gamma-2 [40-467]
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
- 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
- acetylcholine receptor subunit alpha/beta/delta/gamma
- amp-activated protein kinase, gamma-1 subunit
- camp-dependent protein kinase catalytic subunit gamma
- eukaryotic translation initiation factor 4 gamma 1
- gamma-aminobutyric acid receptor subunit alpha (gabaa)
- gamma-aminobutyric acid receptor subunit alpha-1
- gamma-aminobutyric acid receptor subunit alpha-3
- gamma-aminobutyric acid receptor subunit beta-1
- gamma-aminobutyric acid receptor subunit rho-1
- gamma-aminobutyric acid receptor subunit rho-2
- gamma-aminobutyric acid receptor subunit rho-3
- mitogen-activated protein kinase 12 (p38 gamma)
- nicotinic acetylcholine receptor alpha1/beta1/gamma/delta
- nuclear receptor ror-gamma (aa 262-507)
- nuclear receptor ror-gamma [258-518,y502f]
- peroxisome proliferator-activated receptor alpha/delta/gamma
- peroxisome proliferator-activated receptor gamma [205-505]
- voltage-dependent calcium channel gamma-1 subunit
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,a118c]
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,m169c]
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,t120c]
- acetylcholine receptor protein alpha/beta/delta/gamma chain
- gabaa receptor, alpha-3, beta-2, gamma-2
- gabaa receptor, alpha-4, beta-3, gamma-2
- gabaa receptor, alpha-5, beta-2, gamma-2
- gabaa receptor, alpha-5, beta-3, gamma-2
- gabaa subunit alpha-1, beta-2, gamma-2
- gamma-aminobutyric acid receptor subunit alpha-2 (gabra2)
- gamma-aminobutyric acid receptor subunit alpha-2/delta
- phosphatidylinositol 3-kinase c2 domain-containing subunit gamma
- phosphatidylinositol 4-phosphate 5-kinase type i gamma
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
- pi(5)p 4-kinase type ii gamma
- retinoic acid-related nuclear receptor gamma t (rorgammat)
- retinoid x receptor gamma/retinoic acid receptor alpha
- serine/threonine-protein phosphatase pp1-gamma catalytic subunit
- gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-200],p14867[176-456]
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [663-759]
- ampk complex 1 (alpha-1,beta-1,gamma-1)
- ampk complex 7 (alpha-2,beta-1,gamma-1)
- gaba a receptor alpha-1/beta-1/gamma-2
- gaba a receptor alpha-2/beta-2/gamma-2
- gaba a receptor alpha-3/beta-2/gamma-2
- gaba a receptor alpha-4/beta-3/gamma-2
- gaba a receptor alpha-5/beta-3/gamma-2
- gaba a receptor alpha-6/beta-2/gamma-2
- gaba receptor alpha-1/beta-1/gamma-2 subunit
- gaba receptor alpha-1/beta-2/gamma-2 subunit
- gaba receptor alpha-2/beta-2/gamma-2 subunit
- gaba receptor alpha-2/beta-3/gamma-2 subunit
- gaba receptor alpha-3/beta-3/gamma-2 subunit
- gaba receptor alpha-4/beta-3/gamma-2 subunit
- gaba receptor alpha-5/beta-3/gamma-2 subunit
- gaba receptor alpha-6/beta-2/gamma-2 subunit
- gaba-a receptor; alpha-1/beta-3/gamma-2
- gaba-a receptor; alpha-5/beta-3/gamma-2
- gaba-a receptor; alpha-6/beta-3/gamma-2
- gamma-aminobutyric acid receptor (gaba(a)) subunit alpha-4
- gamma-aminobutyric acid receptor subunit alpha-1/beta-1
- gamma-aminobutyric acid receptor subunit alpha-1/beta-2
- gamma-aminobutyric acid receptor subunit alpha-1/beta-3
- gamma-aminobutyric acid receptor subunit alpha-4/beta-3
- gamma-aminobutyric acid receptor subunit alpha-4/beta3/delta
- gamma-aminobutyric acid receptor subunit alpha-6/beta-2
- gamma-aminobutyric acid receptor subunit alpha-6/beta-3
- gamma-aminobutyric acid receptor subunit beta-1/beta-2
- gamma-aminobutyric acid type b receptor subunit 1/2
- peroxisome proliferator-activated receptor gamma/nuclear receptor corepressor 2
- phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit gamma (pik3cg)
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
- phosphorylase b kinase gamma catalytic chain, liver/testis isoform
- protein-glutamine gamma-glutamyltransferase 2/tyrosine-protein kinase jak3
- retinoic acid-related nuclear receptor gamma t (ror t)
- serine/threonine-protein phosphatase 2b catalytic subunit gamma isoform
- amp-activated protein kinase alpha-2/beta-2/gamma-2
- calcium/calmodulin-dependent protein kinase type ii subunit gamma (camkllg)
- gabaa receptor mutant, alpha-1 (a160c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (d97c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (f99c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (g157c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (s204c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (t162c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1 (y209c), beta-2, gamma-2
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (d56c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (f77c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (l140c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r132c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r144c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r185c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (r194c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (t126c)
- gabaa receptor mutant, alpha-1, beta-2, gamma-2 (t142c)
- gamma-aminobutyric acid receptor subunit alpha-1/beta-2/delta
- gamma-aminobutyric acid receptor subunit alpha-1/beta-3/delta
- gamma-aminobutyric acid receptor subunit alpha-4/beta-1/delta
- gamma-aminobutyric acid receptor subunit alpha-4/beta-2/delta
- gamma-aminobutyric acid receptor subunit alpha-4/beta-3/delta
- gamma-aminobutyric acid receptor subunit alpha-6/beta-2/delta
- gamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta
- peroxisome proliferator-activated receptor gamma/retinoic acid receptor rxr-alpha
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/gamma isoform
- phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (144-1102)
- protein-glutamine gamma-glutamyltransferase 2/receptor-type tyrosine-protein phosphatase eta
- calcium/calmodulin-dependent protein kinase type ii subunit alpha/beta/delta/gamma
- peroxisome proliferator-activated receptor gamma [182-505]/regulatory protein gal4 [1-147]
- phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta/gamma isoform
- protein kinase c alpha/beta/delta/epsilon/eta/gamma/theta/zeta type
taxol CHEMBL428647 BDBM50001839 PACLITAXEL
Guanosine 5 -(gamma-S)triphosphate BDBM35866 GTP-gamma-S gamma-Thio-GTP
3-(gamma,gamma-dimethylallyl)resveratrol BDBM50269596 CHEMBL457145
BDBM50269598 3-(gamma,gamma-dimethylpropenyl)moracinM CHEMBL463125
BDBM50269599 5-(gamma,gamma-dimethylallyl)-oxyresveratrol CHEMBL463126
gamma-cyclodextrin BDBM36126
alpha-methyl-gamma,gamma-diphenylallenecarboxylic acid ethyl ester CHEMBL443611 BDBM50292631
CHEMBL558092 BDBM50294101 N1-Benzylamine-N3-(gamma,gamma-dimethylallyl)guanidine Bis-(trifluoroacetate)
TMe-gamma-cyclodextrin BDBM36248
gamma-methyl-APB BDBM82005
4-[N3-gamma,gamma-Dimethyallyl)guanidino]-1-guanidino-butane bis(trifluoroacetate) BDBM50294103 CHEMBL549342
BDBM50205417 CHEMBL220200 UTP-gamma-S
BDBM50250088 [gamma-lactam4,5]PACAP27 CHEMBL524528
BDBM50250089 CHEMBL501268 [gamma-lactam4,5]PACAP38
CHEMBL514745 3'-[gamma-hydroxymethyl-(E)-gamma-methylallyl]-2,4,2',4'-tetrahydroxychalcone 11'-O-coumarate BDBM50250979
N1-[3'-Aminopropyl)-3-aminopropyl]-N3-(gamma,gamma-dimethylallyl)-guanidine bis(trifluoroacetate) CHEMBL553638 BDBM50294102
Cycloartenol Trans-Ferulate BDBM50483936 Gamma Oryzanol 3-O-Ferulylcycloartenol Cycloartenyl Ferulate Cycloartenol Ferulate Gamma-Oryzanol
KWELL Gammallin Gexane BDBM50410525 LINDANE HEXICIDE Gamma Benzene Hydrochloride Gammaxene GAMENE HEXACHLORANE BENZENE HEXACHLORIDE, GAMMA
BDBM50275048 CHEMBL446976 2-octyl gamma-bromoacetoacetate
BDBM92992 L-glutamate gamma-methyl ester
CHEMBL1098291 BDBM50531188 Carnosic Acid Gamma-Lactone
CHEMBL244883 BDBM50199731 methotrexate gamma-hydroxamic acid
CHEMBL85937 BDBM50104419 Glutamyl-gamma-boronate analogue
CHEMBL87796 Glutamyl-gamma-boronate analogue BDBM50104413
NSC_440317 BDBM86479 CAS_440317 ATP,Gamma S
alpha, gamma-diketo acid, 1 BDBM33409
(2S)-6-(gamma,gamma-dimethylallyl)-3',4'-dimethoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone BDBM50241693 CHEMBL516860
CHEMBL267603 BDBM50199734 folate gamma-L-phenylalaninehydroxamic acid
US9328123, Rotenone B BDBM224807 Gamma-irradiated rotenone
methotrexate gamma-L-phenylalaninehydroxamic acid CHEMBL396296 BDBM50199733
CHEMBL464609 BDBM50241692 (2S)-6-(gamma,gamma-dimethylallyl)-5,4'-dihydroxy-3'-methoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone
4-Hydroxyvaleric acid lactone dihydro-5-methyl-2(3H)-furanone gamma-valerolactone 4-Valerolactone gamma-Pentanolactone 4-Methyl-4-hydroxybutanoic acid lactone CHEMBL195593 5-methyldihydrofuran-2(3H)-one BDBM50168010 4-Pentanolide gamma-Pentalactone 4-Methyl-gamma-butyrolactone 4-Hydroxypentanoic acid lactone
(2S)-6-(gamma,gamma-dimethylallyl)-5-3'-dihydroxy-4'-methoxy-6'',6''dimethylpyran[2'',3''7,8]flavanone CHEMBL451703 BDBM50241688
CHEMBL455606 BDBM50241687 (2S)-6-(gamma,gamma-dimethylallyl)-5-hydroxy-3',4'-dimethoxy-6'',6''-dimethylpyran[2'',3'':7,8]flavanone
CHEMBL494570 1-(6-aminohexyl)-3-(3-methylbut-2-enyl)guanidine BDBM50294113 N-(gamma,gamma-Dimethylallyl)-N-(6-aminohexyl)-guanidine
N-(gamma,gamma-Dimethylallyl)-N-(5-aminopentyl)-guanidine BDBM50294112 1-(5-aminopentyl)-3-(3-methylbut-2-enyl)guanidine CHEMBL495424
CHEMBL1398 Alpha-Phenyl-Gamma-Butyrolactone alpha-phenylbutyrolactone BDBM50180937
CHEMBL388879 methotrexate gamma-L-proline-hydroxamic acid BDBM50199735
Gamma2-MSH GAMMA-MSH BDBM82413 CAS_72711-43-4
GHB BDBM50023575 4-hydroxybutanoic acid 4-hydroxybutyric acid 4-hydroxy-butyric acid CHEMBL1342 Xyrem gamma-hydroxybutyric acid Gamma Hydroxybutyric Acid
4,4-difluoro-N(gamma)-hydroxy-L-arginine CHEMBL476417 BDBM50266728
2-Nitrooxy-N-[3-(1,2,3,4-tetrahydro-acridin-9-ylamino)-propyl]-acetamide 9-[N-gamma-(2'-(nitrooxy)acetyl)-gamma-aminopropylamino]-1,2,3,4-tetrahydroacridine CHEMBL269865 BDBM50233367
BDBM50270551 P1,P4-di(uridine 5'-)beta,gamma-difluoromethylenetetraphosphate CHEMBL502712
CAS_57659-38-8 Acetylenic GABA-7 BDBM81477 GAMMA-ACETYLENIC GABA
P1,P4-di(uridine 5'-)beta,gamma-dichloromethlyenetetraphosphate BDBM50270552 CHEMBL476021
adenosine 5'-O-(3-thiotriphosphate) ATP{gamma}S BDBM36312
9-[N-gamma-(3'-(nitrooxy)propyl)-gamma-aminobutylamino]-1,2,3,4-tetrahydroacridine BDBM50233374 N-(3-Nitrooxy-propyl)-N'-(1,2,3,4-tetrahydro-acridin-9-yl)-butane-1,4-diamine CHEMBL407320
2,8-dimethyl-5-(2-pyrazine-2-ylethyl)-gamma-carboline CHEMBL1783970 BDBM50346049
1-(Guanidino)-17-(N1-(gamma,gamma-dimethylallyl)guanidino)-9-azaheptadecane tris(trifluoroacetate) BDBM50294104 CHEMBL560699 N-(8-{8-[N'-(3-Methyl-but-2-enyl)-guanidino]-octylamino}-octyl)-guanidine
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- Parker, MF; Barten, DM; Bergstrom, CP; Bronson, JJ; Corsa, JA; Deshpande, MS; Felsenstein, KM; Guss, VL; Hansel, SB; Johnson, G; Keavy, DJ; Lau, WY; Mock, J; Prasad, CV; Polson, CT; Sloan, CP; Smith, DW; Wallace, OB; Wang, HH; Williams, A; Zheng, M N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors. Bioorg Med Chem Lett 17: 4432-6 (2007)
- Gunasekera, SP; Isbrucker, RA; Longley, RE; Wright, AE; Pomponi, SA; Reed, JK Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp. J Nat Prod 67: 110-1 (2004)
- Jiang, X; Bender, CF; Visnick, M; Hotema, MR; Sheldon, ZS; Lee, C; Caprathe, BW; Bolton, G; Kornberg, B Pyrimidine tricyclic enone derivatives for inhibition of ROR-gamma and other uses US Patent US11292781 (2022)
- Josien, H; Bara, T; Rajagopalan, M; Asberom, T; Clader, JW; Favreau, L; Greenlee, WJ; Hyde, LA; Nomeir, AA; Parker, EM; Pissarnitski, DA; Song, L; Wong, GT; Zhang, L; Zhang, Q; Zhao, Z Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors. Bioorg Med Chem Lett 17: 5330-5 (2007)
- Toyota, Y; Nomura, S; Makishima, M; Hashimoto, Y; Ishikawa, M Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression. Bioorg Med Chem Lett 27: 2776-2780 (2017)
- Kitas, EA; Galley, G; Jakob-Roetne, R; Flohr, A; Wostl, W; Mauser, H; Alker, AM; Czech, C; Ozmen, L; David-Pierson, P; Reinhardt, D; Jacobsen, H Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors. Bioorg Med Chem Lett 18: 304-8 (2008)
- Sparey, T; Clarke, E; Hannam, J; Harrison, T; Madin, A; Shearman, M; Sohal, B Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors. Bioorg Med Chem Lett 18: 375-9 (2008)
- Nadin, A; Owens, AP; Castro, JL; Harrison, T; Shearman, MS Synthesis and gamma-secretase activity of APP substrate-based hydroxyethylene dipeptide isosteres. Bioorg Med Chem Lett 13: 37-41 (2002)
- Müller-Uri, C; Singer, EA; Fleischhacker, W Synthesis of alkyl-substituted arecoline derivatives as gamma-aminobutyric acid uptake inhibitors. J Med Chem 29: 125-32 (1986)
- Reynisson, J; Court, W; O'Neill, C; Day, J; Patterson, L; McDonald, E; Workman, P; Katan, M; Eccles, SA The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg Med Chem 17: 3169-76 (2009)
- Chebib, M; Vandenberg, RJ; Froestl, W; Johnston, GA Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists. Eur J Pharmacol 329: 223-9 (1997)
- ChEMBL_1618264 (CHEMBL3860433) Displacement of [125I]-CXCL12 from HA-tagged human recombinant CXCR4 expressed in HEK293 cells incubated for 1 hr by gamma-radiation counting analysis
- ChEMBL_839291 (CHEMBL2077962) TP_TRANSPORTER: drug resistance (paclitaxel) in HCT15/CL02 cells
- ChEMBL_1487657 (CHEMBL3532643) Reversible inhibition of human CYP2C8 paclitaxel 6alpha-hydroxylase activity
- ChEMBL_1904909 (CHEMBL4407267) Inhibition of CYP2C8 (unknown origin) using paclitaxel as substrate
- ChEMBL_838757 (CHEMBL2078583) TP_TRANSPORTER: drug resistance (paclitaxel) in MES-SA/DX5 cells
- ChEMBL_1827556 (CHEMBL4327430) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM
- ChEMBL_2116914 (CHEMBL4825980) Inhibition of paclitaxel stimulated- P-gp ATPase activity (unknown origin)
- ChEMBL_1797586 (CHEMBL4269703) Inhibition of ATM phosphorylation at Ser1981 residue in human HT-29 cells using ionizing radiation
- ChEMBL_2116923 (CHEMBL4825989) Inhibition of P-gp (unknown origin) expressed in MCF7 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring reduction in paclitaxel EC50 at 50 nM incubated for 72 hrs in presence of paclitaxel by SRB assay (Rvb = 11.5 nM)
- ChEMBL_2151595 (CHEMBL5036057) Inhibition of CYP2C8 in human liver microsome using paclitaxel as substrate
- ChEMBL_1797587 (CHEMBL4269704) Inhibition of DNA-PK phosphorylation at Ser2056 residue in human HT-29 cells using ionizing radiation
- ChEMBL_2024838 (CHEMBL4678651) Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4.23 +/- 0.6 uM)
- ChEMBL_2116924 (CHEMBL4825990) Inhibition of P-gp (unknown origin) expressed in MES-SA/DX5 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring reduction in paclitaxel EC50 at 50 nM incubated for 72 hrs in presence of paclitaxel by SRB assay (Rvb = 294.6 nM)
- ChEMBL_2444934 Inhibition of P-gp in human Caco-2 cells in presence of paclitaxel
- ChEMBL_2024816 (CHEMBL4678629) Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 4 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 91.40 +/- 23.32 nM)
- ChEMBL_2024817 (CHEMBL4678630) Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 20 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 91.40 +/- 23.32 nM)
- ChEMBL_2024818 (CHEMBL4678631) Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 91.40 +/- 23.32 nM)
- ChEMBL_2024829 (CHEMBL4678642) Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 4 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 1886.37 +/- 243.05 nM)
- ChEMBL_2024830 (CHEMBL4678643) Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 20 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 1886.37 +/- 243.05 nM)
- ChEMBL_2024834 (CHEMBL4678647) Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 4 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4233.18 +/- 499.10 nM)
- ChEMBL_2024835 (CHEMBL4678648) Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 20 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4233.18 +/- 499.10 nM)
- ChEMBL_2024836 (CHEMBL4678649) Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 4233.18 +/- 499.10 nM)
- ChEMBL_2024839 (CHEMBL4678652) Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay (Rvb = 1886.37 +/- 243.05 nM)
- ChEMBL_1587229 (CHEMBL3825965) Inhibition of ABCB1 in human KBVIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 8 uM after 72 hrs by SRB assay (Rvb = 1196.09 +/- 44.8 nM)
- ChEMBL_1587230 (CHEMBL3825966) Inhibition of ABCB1 in human KBVIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 1196.09 +/- 44.8 nM)
- ChEMBL_1755244 (CHEMBL4190004) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 1 uM after 4 days by CellTiter-Glo assay (Rvb = 1202 nM)
- ChEMBL_1755245 (CHEMBL4190005) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 3 uM after 4 days by CellTiter-Glo assay (Rvb = 1202 nM)
- ChEMBL_1755246 (CHEMBL4190006) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 10 uM after 4 days by CellTiter-Glo assay (Rvb = 1202 nM)
- ChEMBL_1755247 (CHEMBL4190007) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 20 uM after 4 days by CellTiter-Glo assay (Rvb = 1202 nM)
- ChEMBL_1755248 (CHEMBL4190008) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of paclitaxel-mediated cytotoxicity by measuring paclitaxel IC50 at 30 uM after 4 days by CellTiter-Glo assay (Rvb = 1202 nM)
- ChEMBL_496041 (CHEMBL998471) Displacement of [3H]paclitaxel from pig biotinylated tubulin after 2 hrs by SPA
- ChEMBL_1741905 (CHEMBL4157655) Inhibition of ABCB1 in human SW620/Ad300 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 3.39 +/- 0.84 microM)
- ChEMBL_1741906 (CHEMBL4157656) Inhibition of ABCB1 in human SW620/Ad300 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 20 uM after 72 hrs by MTT assay (Rvb = 3.39 +/- 0.84 microM)
- ChEMBL_1741907 (CHEMBL4157657) Inhibition of ABCB1 in human SW620/Ad300 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 4 uM after 72 hrs by MTT assay (Rvb = 3.39 +/- 0.84 microM)
- ChEMBL_1741941 (CHEMBL4157691) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 0.09 +/- 0.02 microM)
- ChEMBL_1741942 (CHEMBL4157692) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 20 uM after 72 hrs by MTT assay (Rvb = 0.09 +/- 0.02 microM)
- ChEMBL_1741943 (CHEMBL4157693) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 4 uM after 72 hrs by MTT assay (Rvb = 0.09 +/- 0.02 microM)
- ChEMBL_2089947 (CHEMBL4771210) Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 11.8 +/- 1.13 nM)
- ChEMBL_2089948 (CHEMBL4771211) Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 11.8 +/- 1.13 nM)
- ChEMBL_2089959 (CHEMBL4771222) Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 26.50 +/- 4.1 nM)
- ChEMBL_2089960 (CHEMBL4771223) Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 26.50 +/- 4.1 nM)
- ChEMBL_2089965 (CHEMBL4771228) Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 1762 +/- 63 nM)
- ChEMBL_2089966 (CHEMBL4771229) Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 1762 +/- 63 nM)
- ChEMBL_2151092 (CHEMBL5035554) Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay
- ChEMBL_161149 (CHEMBL767417) Inhibition of Protein kinase C gamma (PKC-gamma)
- ChEMBL_1668632 (CHEMBL4018520) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 mins
- ChEMBL_874592 (CHEMBL2186228) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 10 mins
- ChEMBL_1500054 (CHEMBL3584050) Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for paclitaxel at 1 uM after 5 days by CellTiter 96 Aqueous assay
- ChEMBL_1500167 (CHEMBL3584716) Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for paclitaxel at 10 uM after 5 days by CellTiter 96 Aqueous assay
- ChEMBL_1827565 (CHEMBL4327439) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 24 hrs by MTT assay (Rvb = 3837.57 uM)
- ChEMBL_1827566 (CHEMBL4327440) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 24 hrs by MTT assay (Rvb = 3837.57 uM)
- ChEMBL_1827569 (CHEMBL4327443) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 1396.57 uM)
- ChEMBL_1827570 (CHEMBL4327444) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 1396.57 uM)
- ChEMBL_2111356 (CHEMBL4820206) Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by MTT assay
- ChEMBL_2111357 (CHEMBL4820207) Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM measured after 72 hrs by MTT assay
- ChEBML_154356 Binding affinity towards peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEBML_154541 Binding affinity for Peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_196000 (CHEMBL800489) Binding affinity for Retinoic Acid Receptor gamma (RAR gamma)
- ChEMBL_1826942 (CHEMBL4326816) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 72 hrs by MTT assay (Rvb = 1353.98 +/- 303.33 nM)
- ChEMBL_1826943 (CHEMBL4326817) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 1353.98 +/- 303.33 nM)
- ChEMBL_1827560 (CHEMBL4327434) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 398.34 +/- 0.58 uM)
- ChEMBL_1827561 (CHEMBL4327435) Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 72 hrs by MTT assay (Rvb = 398.34 +/- 0.58 uM)
- ChEMBL_1862982 (CHEMBL4363838) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 72 hrs by MTT assay (Rvb = 352.31 +/- 10.9 nM)
- ChEMBL_1862983 (CHEMBL4363839) Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by MTT assay (Rvb = 352.31 +/- 10.9 nM)
- ChEMBL_2111360 (CHEMBL4820210) Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by MTT assay
- ChEMBL_2111361 (CHEMBL4820211) Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM measured after 72 hrs by MTT assay
- ChEMBL_2135225 (CHEMBL4844835) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 0.5 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay
- ChEMBL_2135226 (CHEMBL4844836) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 1 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay
- ChEMBL_2135227 (CHEMBL4844837) Inhibition of ABCB1 (unknown origin) expressed in HEK293T cells assessed as reduction in paclitaxel IC50 at 2 uM pre-incubated for 4 hrs followed by paclitaxel addition and measured after 72 hrs by MTT assay
- ChEMBL_1508932 (CHEMBL3602151) Modulation of P-gp in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistance
- ChEMBL_1864328 (CHEMBL4365303) Inhibition of Pgp (unknown origin) expressed in MDCK cells assessed as reduction in paclitaxel transport
- ChEMBL_572591 (CHEMBL1025207) Inhibition of CYP2C8 in human liver microsomes assessed as inhibition of paclitaxel 6-alpha-hydroxylation
- ChEMBL_854489 (CHEMBL2160811) Inhibition of human CYP2C8 in liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 48 hrs
- ChEMBL_1587212 (CHEMBL3825948) Inhibition of full length human ABCB1 expressed in Flp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 8 uM after 72 hrs by SRB assay (Rvb = 644.78 +/- 2.6 nM)
- ChEMBL_1587213 (CHEMBL3825949) Inhibition of full length human ABCB1 expressed in Flp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 72 hrs by SRB assay (Rvb = 644.78 +/- 2.6 nM)
- ChEMBL_154356 (CHEMBL759117) Binding affinity towards peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_154522 (CHEMBL762149) Binding affinity against Peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_154525 (CHEMBL762152) Binding affinity against peroxisome proliferator activated receptor gamma (PPAR-gamma)
- ChEMBL_2089953 (CHEMBL4771216) Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured after 72 hrs by SRB assay (Rvb = 797 +/- 73 nM)
- ChEMBL_2089954 (CHEMBL4771217) Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM measured after 72 hrs by SRB assay (Rvb = 797 +/- 73 nM)
- ChEMBL_1501739 (CHEMBL3587719) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate by LC-MS/MS analysis
- ChEMBL_1655299 (CHEMBL4004665) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 15 mins
- ChEMBL_2156137 (CHEMBL5040797) Inhibition of CYP2C8 in human liver microsomes using Paclitaxel as substrate by LC-MS/MS analysis
- ChEMBL_738490 (CHEMBL1743391) Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using human liver microsomes
- ChEMBL_738491 (CHEMBL1743392) Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using human liver microsomes
- ChEMBL_738492 (CHEMBL1743393) Mechanism based inhibition of human cytochrome P450 2C8 measured by paclitaxel hydroxylation using a recombinant system
- ChEMBL_850903 (CHEMBL2156886) Inhibition of human CYP2C8 using paclitaxel as substrate after 45 mins by LC/MS/MS analysis
- ChEBML_154188 In vitro activation of human peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_154215 (CHEMBL759460) Binding affinity against human Peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_305792 (CHEMBL827980) Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP
- ChEMBL_1855736 (CHEMBL4356465) Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 3 uM after 48 hrs by MTT assay (Rvb = 2120 nM)
- ChEMBL_1855745 (CHEMBL4356474) Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 2120 nM)
- ChEMBL_1855746 (CHEMBL4356475) Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 7 uM after 48 hrs by MTT assay (Rvb = 2120 nM)
- ChEMBL_1855747 (CHEMBL4356476) Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 2120 nM)
- ChEBML_153616 In vitro transcription activation on human peroxisome proliferator activated receptor-gamma (PPAR gamma)
- ChEBML_222303 In vitro binding affinity against human PPAR gamma (peroxisome proliferator-activated gamma receptor)
- ChEMBL_154361 (CHEMBL756623) In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma)
- ChEMBL_154548 (CHEMBL757883) In vitro binding affinity against human PPAR gamma (peroxisome proliferator-activated gamma receptor)
- ChEMBL_222303 (CHEMBL841917) In vitro binding affinity against human PPAR gamma (peroxisome proliferator-activated gamma receptor)
- ChEMBL_1284966 (CHEMBL3108547) Modulation of p-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversal of paclitaxel resistance
- ChEBML_154534 Agonist activity against PPAR gamma
- ChEBML_68901 Inhibitory activity against gamma-secretase
- ChEMBL_358169 (CHEMBL854203) Inhibition of gamma secretase
- ChEMBL_364830 (CHEMBL870177) Inhibition of PPAR gamma
- ChEMBL_389284 (CHEMBL868040) Inhibition of PTP gamma
- ChEMBL_438619 (CHEMBL888950) Inhibition of gamma-secretase
- ChEMBL_453103 (CHEMBL902249) Inhibition of Gamma-secretase
- ChEMBL_458481 (CHEMBL941797) Inhibition of PKC gamma
- ChEMBL_458510 (CHEMBL941826) Inhibition of P38 gamma
- ChEMBL_475761 (CHEMBL930277) Inhibition of p38-gamma
- ChEMBL_481048 (CHEMBL997488) Inhibition of PKC gamma
- ChEMBL_489230 (CHEMBL989977) Inhibition of p38beta/gamma
- ChEMBL_509592 (CHEMBL1001353) Inhibition of PI3K gamma
- ChEMBL_582355 (CHEMBL1063392) Inhibition of p38-gamma
- ChEMBL_606945 (CHEMBL1072688) Inhibition of p38-gamma
- ChEMBL_625017 (CHEMBL1109685) Inhibition of p38-gamma
- ChEMBL_627033 (CHEMBL1104515) Inhibition of p38-gamma
- ChEMBL_644879 (CHEMBL1211156) Inhibition of p38-gamma
- ChEMBL_664522 (CHEMBL1259904) Inhibition of PI3K-gamma
- ChEMBL_716959 (CHEMBL1670987) Inhibition of PPAR gamma
- ChEMBL_758493 (CHEMBL1811571) Inhibition of p38-gamma
- ChEMBL_68435 (CHEMBL683047) Binding affinity against Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2
- ChEMBL_70702 (CHEMBL685338) Binding affinity for Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2
- ChEMBL_757720 (CHEMBL1809664) Inhibition of PLK1 assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
- ChEMBL_1493770 (CHEMBL3530853) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysis
- ChEMBL_1616316 (CHEMBL3858385) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC/MS/MS analysis
- ChEMBL_1703503 (CHEMBL4054736) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 15 mins by LC-MS/MS analysis
- ChEMBL_1932999 (CHEMBL4478651) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 10 mins by LC/MS/MS analysis
- ChEMBL_2066470 (CHEMBL4721723) Inhibition of human liver microsome CYP2C8 using paclitaxel as substrate incubated for 20 mins by LC-MS/MS analysis
- ChEMBL_977241 (CHEMBL2416912) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 20 mins by LC-MS analysis
- ChEMBL_302648 (CHEMBL839938) Binding affinity towards gamma-aminobutyric-acid GABA-A receptor alpha-4-beta-3-gamma-2
- ChEMBL_302649 (CHEMBL839939) Binding affinity towards gamma-aminobutyric-acid GABA-A receptor alpha-6-beta-3-gamma-2
- ChEMBL_69813 (CHEMBL678910) Direct activation of human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2
- ChEMBL_757718 (CHEMBL1809662) Inhibition of Aur-A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
- ChEMBL_2271780 Inhibition of ATR in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblotting analysis
- ChEMBL_2271781 Inhibition of ATM in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblotting analysis
- ChEMBL_1281756 (CHEMBL3100525) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 20 mins by LC-MS/MS analysis
- ChEMBL_813100 (CHEMBL2020719) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins by LC-MS/MS analysis
- ChEBML_153125 Inhibition of protein kinase C-gamma
- ChEBML_153154 Inhibition of protein kinase C gamma
- ChEBML_154532 Activity against murine PPAR gamma receptor
- ChEBML_161146 Inhibition of Protein kinase C gamma
- ChEBML_161147 Inhibition of Protein kinase C gamma
- ChEBML_161148 Inhibition of Protein kinase C gamma
- ChEBML_161284 Inhibition of Protein kinase C gamma
- ChEBML_161285 Inhibition of Protein kinase C gamma
- ChEBML_163495 Effective concentration against RAR-gamma receptor
- ChEMBL_1349386 (CHEMBL3269976) Inhibition of human PPAR-gamma
- ChEMBL_1762449 (CHEMBL4197696) Inhibition of human gamma-secretase
- ChEMBL_208172 (CHEMBL819078) Binding affinity against gamma thrombin
- ChEMBL_2267333 Inhibition of p110 gamma (unknown origin)
- ChEMBL_2272293 Inhibition of gamma-secretase (unknown origin)
- ChEMBL_2272599 Inhibition of PI3K gamma (unknown origin)
- ChEMBL_2294027 Inhibition of gamma-secretase (unknown origin)
- ChEMBL_2422156 Agonist activity at human PPAR gamma
- ChEMBL_2517236 Inhibition of p110 gamma (unknown origin)
- ChEMBL_2583445 Inhibition of PI3K gamma (unknown origin)
- ChEMBL_377005 (CHEMBL868560) Inhibition of DNA polymerase gamma
- ChEMBL_463059 (CHEMBL928969) Inhibition of human p38-gamma
- ChEMBL_612859 (CHEMBL1067548) Inhibition of p38-gamma MAPK
- ChEMBL_655504 (CHEMBL1244548) Binding affinity to p38-gamma
- ChEMBL_687469 (CHEMBL1292145) Inhibition of human PKC-gamma
- ChEMBL_773493 (CHEMBL1839859) Inhibition of recombinant p38-gamma
- Inhibition Assay Inhibition assay using gamma-secretase.
- ChEMBL_154354 (CHEMBL880951) Binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) was determined by HTRF assay
- ChEMBL_70537 (CHEMBL681094) Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2
- ChEMBL_70714 (CHEMBL682418) Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2
- ChEMBL_757717 (CHEMBL1809661) Inhibition of MPS1 assessed as [33P]-gamma-ATP incorporation into substrate P38-betatide by gamma counting
- ChEMBL_757719 (CHEMBL1809663) Inhibition of CDK2/Cyclin A assessed as [33P]-gamma-ATP incorporation into substrate by gamma counting
- ChEMBL_2451239 Inhibition of human URAT1 expressed in HEK293T cells using 14C- uric acid assessed as uric acid absorption by measuring intracellular liquid radiation value by liquid scintillation counting analysis
- ChEMBL_2452064 Inhibition of PI3K p110-gamma (unknown origin) in presence of [gamma-32P]ATP by radioactivity based kinase assay
- ChEMBL_631390 (CHEMBL1109142) Inhibition of Plk2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631391 (CHEMBL1109143) Inhibition of Plk3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631403 (CHEMBL1109155) Inhibition of VEGFR3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631405 (CHEMBL1109157) Inhibition of KIT assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631407 (CHEMBL1109159) Inhibition of AKT1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631408 (CHEMBL1109160) Inhibition of ALK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631410 (CHEMBL1109162) Inhibition of CDC7 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631411 (CHEMBL1109163) Inhibition of CDK7 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631413 (CHEMBL1111118) Inhibition of CHK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631415 (CHEMBL1111952) Inhibition of ERK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631416 (CHEMBL1111953) Inhibition of FGFR1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631417 (CHEMBL1111954) Inhibition of IGF1R assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631419 (CHEMBL1111956) Inhibition of IKK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631421 (CHEMBL1111958) Inhibition of LCK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631422 (CHEMBL1111959) Inhibition of MAPKAPK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631423 (CHEMBL1111960) Inhibition of MET assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631424 (CHEMBL1111961) Inhibition of NEK6 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631426 (CHEMBL1111963) Inhibition of PAK4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631427 (CHEMBL1111964) Inhibition of PDK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631430 (CHEMBL1111967) Inhibition of p38alpha assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631431 (CHEMBL1111968) Inhibition of RET assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631432 (CHEMBL1111969) Inhibition of STK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631434 (CHEMBL1111971) Inhibition of TrkA assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631617 (CHEMBL1106611) Inhibition of VEGFR2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_68433 (CHEMBL683045) Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2
- ChEMBL_69814 (CHEMBL678911) Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2
- ChEMBL_70099 (CHEMBL678329) Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2
- ChEMBL_70261 (CHEMBL681248) Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2
- ChEMBL_70416 (CHEMBL682251) Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2
- ChEMBL_70695 (CHEMBL681480) Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2
- ChEMBL_745831 (CHEMBL1776201) Inhibition of NEK6 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745832 (CHEMBL1776202) Inhibition of NIM1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745833 (CHEMBL1776203) Inhibition of P38alpha assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745834 (CHEMBL1776204) Inhibition of PAK4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745836 (CHEMBL1776206) Inhibition of PDK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745837 (CHEMBL1776207) Inhibition of EphA2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745838 (CHEMBL1776208) Inhibition of ERK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745839 (CHEMBL1776209) Inhibition of FAK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745840 (CHEMBL1776210) Inhibition of FGFR1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745842 (CHEMBL1776212) Inhibition of Haspin assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745843 (CHEMBL1776213) Inhibition of IGFR1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745844 (CHEMBL1776214) Inhibition of IKK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745845 (CHEMBL1776215) Inhibition of IR assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745846 (CHEMBL1776216) Inhibition of JAK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745847 (CHEMBL1776217) Inhibition of JAK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745848 (CHEMBL1776218) Inhibition of KIT assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745849 (CHEMBL1776219) Inhibition of LCK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745850 (CHEMBL1776220) Inhibition of LYN assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745851 (CHEMBL1776221) Inhibition of MAPKAPK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745852 (CHEMBL1776222) Inhibition of MET assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745853 (CHEMBL1776223) Inhibition of MNK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745854 (CHEMBL1776224) Inhibition of MPS1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745855 (CHEMBL1776225) Inhibition of MST4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745933 (CHEMBL1776303) Inhibition of PERK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745934 (CHEMBL1776304) Inhibition of PIM1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745935 (CHEMBL1776305) Inhibition of PIM2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745936 (CHEMBL1776306) Inhibition of PKAalpha assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745937 (CHEMBL1776307) Inhibition of PKCbeta assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745938 (CHEMBL1776308) Inhibition of RET assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745939 (CHEMBL1776309) Inhibition of ROS1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745941 (CHEMBL1775240) Inhibition of Syk assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745942 (CHEMBL1775241) Inhibition of TLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745943 (CHEMBL1775242) Inhibition of TRKA assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745944 (CHEMBL1775243) Inhibition of TYK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745945 (CHEMBL1775244) Inhibition of VEGFR2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745946 (CHEMBL1775245) Inhibition of VEGFR3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745947 (CHEMBL1775246) Inhibition of ZAP70 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747145 (CHEMBL1777511) Inhibition of PLK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747146 (CHEMBL1777512) Inhibition of PLK2 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747147 (CHEMBL1777513) Inhibition of PLK3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747248 (CHEMBL1776507) Inhibition of FLT3 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747249 (CHEMBL1776508) Inhibition of MELK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747251 (CHEMBL1776510) Inhibition of ABL assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747252 (CHEMBL1776511) Inhibition of ACK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747253 (CHEMBL1776512) Inhibition of AKT1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747254 (CHEMBL1776513) Inhibition of ALK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747257 (CHEMBL1776516) Inhibition of BRK assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747258 (CHEMBL1776517) Inhibition of BUB1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747265 (CHEMBL1776524) Inhibition of CHK1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747266 (CHEMBL1776525) Inhibition of EEF2K assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_1487046 (CHEMBL3531872) Competitive inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6-hydroxylation after 20 mins by LC-MS/MS analysis
- ChEMBL_1668634 (CHEMBL4018522) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 2 to 40 mins measured after 2 mins
- ChEMBL_993293 (CHEMBL2443950) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 5 to 60 mins by LC-MS/MS analysis
- ChEBML_147141 Binding affinity for gamma-S binding assay
- ChEBML_161272 Inhibition of human Protein kinase C gamma
- ChEBML_161274 Inhibition of human Protein kinase C gamma
- ChEBML_196013 Binding affinity towards Retinoic acid receptor gamma
- ChEBML_196319 Binding affinity against Retinoic acid receptor gamma
- ChEBML_196322 Binding affinity for Retinoic acid receptor gamma
- ChEBML_196329 Binding affinity against Retinoic acid receptor gamma
- ChEBML_306114 In vitro binding affinity for PPAR-gamma
- ChEBML_68902 Inhibitory concentration against gamma-secretase was determined
- ChEMBL_1365495 (CHEMBL3297010) Inhibition of human DNA polymerase gamma
- ChEMBL_1450781 (CHEMBL3363926) Inhibition of PI3K-gamma (unknown origin)
- ChEMBL_153124 (CHEMBL758470) Inhibition of protein kinase C gamma
- ChEMBL_153154 (CHEMBL761877) Inhibition of protein kinase C gamma
- ChEMBL_154187 (CHEMBL762736) Transcriptional activation by human PPAR gamma
- ChEMBL_154211 (CHEMBL759456) Inhibitory concentration of the PPAR gamma)
- ChEMBL_1583672 (CHEMBL3815759) Inhibition of PI3K gamma (unknown origin)
- ChEMBL_161143 (CHEMBL767411) Inhibition of protein kinase C gamma
- ChEMBL_161145 (CHEMBL767413) Inhibition of Protein kinase C gamma
- ChEMBL_161146 (CHEMBL767414) Inhibition of Protein kinase C gamma
- ChEMBL_161284 (CHEMBL766914) Inhibition of Protein kinase C gamma
- ChEMBL_163481 (CHEMBL772394) Transcriptional activation for RAR gamma receptor
- ChEMBL_1762453 (CHEMBL4197700) Inhibition of gamma-secretase (unknown origin)
- ChEMBL_1925267 (CHEMBL4428339) Inhibition of gamma secretase (unknown origin)
- ChEMBL_2026875 (CHEMBL4681033) Agonist activity at human PPAR-gamma
- ChEMBL_2199021 (CHEMBL5111537) Inhibition of human DNA polymerase gamma
- ChEMBL_220901 (CHEMBL824656) Binding affinity at human PPAR gamma
- ChEMBL_339276 (CHEMBL867229) Binding affinity to human PPAR gamma
- ChEMBL_424080 (CHEMBL855083) Displacement of Fluormone from PPAR gamma
- ChEMBL_473713 (CHEMBL939369) Inhibition of p38-gamma MAP kinase
- ChEMBL_476359 (CHEMBL921519) Binding affinity at PPAR gamma receptor
- ChEMBL_533421 (CHEMBL983382) Inhibition of human DNA polymerase gamma
- ChEMBL_537070 (CHEMBL986219) Binding affinity to human p38-gamma
- ChEMBL_68895 (CHEMBL678617) Inhibition of human gamma-secretase activity
- ChEMBL_68900 (CHEMBL676871) In vitro inhibition of gamma secretase.
- ChEMBL_720298 (CHEMBL1679164) Inhibition of human DNA polymerase gamma
- ChEMBL_941101 (CHEMBL2330898) Inhibition of PKC gamma (unknown origin)
- ChEMBL_154377 (CHEMBL758986) in vitro agonist activity against peroxisome proliferator activated receptor-gamma (PPAR-gamma), using alkaline phosphatase activity transactivator assay
- ChEMBL_558101 (CHEMBL956591) Displacement of [3H]GHB from gamma-hydroxybutyrate binding site of gamma-hydroxybutyrate receptor in rat forebrain synaptic membranes
- ChEMBL_631394 (CHEMBL1109146) Inhibition of Aurora A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631401 (CHEMBL1109153) Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631406 (CHEMBL1109158) Inhibition of c-ABL assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631409 (CHEMBL1109161) Inhibition of Aurora B assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631418 (CHEMBL1111955) Inhibition of GSK3-beta assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631420 (CHEMBL1111957) Inhibition of insulin receptor assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631428 (CHEMBL1111965) Inhibition of PKA-alpha assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631429 (CHEMBL1111966) Inhibition of PKC-beta assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_745841 (CHEMBL1776211) Inhibition of GSK3-beta assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747255 (CHEMBL1776514) Inhibition of Aur-A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747256 (CHEMBL1776515) Inhibition of Aur-B assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747259 (CHEMBL1776518) Inhibition of CDC7/DBF4 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747260 (CHEMBL1776519) Inhibition of CDK1/CYCB assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747261 (CHEMBL1776520) Inhibition of CDK2/CYCA assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747262 (CHEMBL1776521) Inhibition of CDK2/CYCE assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747263 (CHEMBL1776522) Inhibition of CDK4/CYCD1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_747264 (CHEMBL1776523) Inhibition of CDK5/P25 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_1487039 (CHEMBL3531865) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6-hydroxylation after 5 to 30 mins by LC-MS/MS analysis
- ChEMBL_1487047 (CHEMBL3532217) Linear mixed inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6-hydroxylation after 20 mins by LC-MS/MS analysis
- ChEMBL_631393 (CHEMBL1109145) Inhibition of CDK2/Cyclin A assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631400 (CHEMBL1109152) Inhibition of CDK1/Cyclin B assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631402 (CHEMBL1109154) Inhibition of CDK2/Cyclin E assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631412 (CHEMBL1111117) Inhibition of CDK4/Cyclin D1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_631414 (CHEMBL1111951) Inhibition of EGFR isoform 1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_68434 (CHEMBL683046) Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2
- ChEMBL_70256 (CHEMBL682715) Agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes
- ChEMBL_70411 (CHEMBL682825) Agonist activity on human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes
- ChEMBL_70701 (CHEMBL685337) Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2
- ChEMBL_1755242 (CHEMBL4190002) Inhibition of ALDH1A1 in human SKOV3TR cells assessed as potentiation of 100 nM paclitaxel-mediated cytotoxicity after 4 days by CellTiter-Glo assay
- ChEBML_139553 Activation of murine PPAR gamma ligand binding domain
- ChEBML_153232 Maximum transcriptional activation of human PPAR gamma receptor
- ChEBML_196016 Binding affinity towards human Retinoic acid receptor gamma
- ChEBML_196170 Transcriptional activation of retinoic acid receptor RAR gamma
- ChEBML_70524 Binding affinity for retinoic acid receptor RAR gamma
- ChEBML_70528 Binding affinity for retinoic acid receptor RAR gamma
- ChEMBL_1442318 (CHEMBL3377679) Binding affinity to PPAR-gamma (unknown origin)
- ChEMBL_153629 (CHEMBL762525) In vitro transcriptional activation by PPAR gamma
- ChEMBL_153632 (CHEMBL762528) In vitro transcriptional activation by PPAR gamma
- ChEMBL_153634 (CHEMBL762530) Final binding affinity against PPAR-gamma receptor
- ChEMBL_153635 (CHEMBL762531) Initial binding affinity against PPAR-gamma receptor
- ChEMBL_161274 (CHEMBL772955) Inhibition of human Protein kinase C gamma
- ChEMBL_161278 (CHEMBL772959) Inhibition of Protein kinase C gamma (PKC)
- ChEMBL_1721611 (CHEMBL4136611) Inhibition of cystathionine gamma-lyase (unknown origin)
- ChEMBL_195999 (CHEMBL800488) Binding affinity for Retinoic acid receptor gamma
- ChEMBL_196001 (CHEMBL800490) Binding affinity for Retinoic acid receptor gamma
- ChEMBL_196006 (CHEMBL797870) Agonistic activity towards retinoic acid receptor-gamma
- ChEMBL_196007 (CHEMBL797871) Antagonistic activity towards retinoic acid receptor-gamma
- ChEMBL_196015 (CHEMBL798025) Selective activity towards retinoic acid receptor-gamma
- ChEMBL_196308 (CHEMBL805023) Transactivation potency for Retinoic acid receptor gamma
- ChEMBL_196322 (CHEMBL806265) Binding affinity for Retinoic acid receptor gamma
- ChEMBL_196640 (CHEMBL800753) Agonistic activity towards retinoid X receptor-gamma
- ChEMBL_196641 (CHEMBL800754) Antagonistic activity towards retinoid X receptor-gamma
- ChEMBL_196642 (CHEMBL800755) Selective activity towards retinoid X receptor-gamma
- ChEMBL_196643 (CHEMBL800756) Synergistic activity towards retinoid X receptor-gamma
- ChEMBL_306114 (CHEMBL830065) In vitro binding affinity for PPAR-gamma
- ChEMBL_320732 (CHEMBL880877) Dissociation constant for Retinoic acid receptor gamma
- ChEMBL_439784 (CHEMBL888894) Displacement of [3H]rosiglitazone from PPAR gamma
- ChEMBL_531813 (CHEMBL991525) Antagonist activity at protein kinase C gamma
- ChEMBL_543160 (CHEMBL1014320) Inhibition of gamma-glutamyltranspeptidase by colorimetric assay
- ChEMBL_586604 (CHEMBL1061183) Binding constant for full-length p38-gamma
- ChEMBL_774246 (CHEMBL1908463) Binding constant for p38-gamma kinase domain
- ChEMBL_978823 (CHEMBL2423425) Inhibition of PI-3K gamma (unknown origin)
- ChEMBL_434338 (CHEMBL919396) Agonist activity at human opioid gamma receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding
- ChEMBL_70095 (CHEMBL678325) Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes
- ChEMBL_70691 (CHEMBL679474) Effective agonist dose for human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes
- ChEMBL_1492464 (CHEMBL3528839) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH
- ChEMBL_1492465 (CHEMBL3528840) Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPH
- ChEMBL_1822761 (CHEMBL4322525) Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assay
- ChEMBL_1839489 (CHEMBL4339704) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate measured after 15 mins in presence of NADPH by LC-MS/MS analysis
- ChEMBL_1904558 (CHEMBL4406780) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate incubated for 40 mins in presence of NADPH by LC-MS/MS analysis
- ChEMBL_1992478 (CHEMBL4626213) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate incubated for 20 mins in presence of NADPH by LC/MS/MS analysis
- ChEMBL_2101711 (CHEMBL4810107) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis
- ChEMBL_2119410 (CHEMBL4828476) Inhibition of P-gp (unknown origin) expressed in human LCC6MDR cells assessed as reversal of paclitaxel resistance after 5 days by MTS/PMS assay
- ChEMBL_70090 (CHEMBL677036) Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2
- ChEMBL_70252 (CHEMBL682711) Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2
- ChEMBL_70257 (CHEMBL681244) Effective dose for agonist activity on human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 in Xenopus oocytes
- ChEMBL_70407 (CHEMBL680434) Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2
- ChEMBL_70552 (CHEMBL680671) Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-5-beta-3-gamma-2
- ChEBML_161307 Binding affinity for protein kinase C gamma-C1B domain
- ChEBML_196331 Inhibition of [3H]ATRA binding to RAR gamma receptor
- ChEBML_221639 Inhibition of p56 lck autophosphorylation, gamma-[33P]ATP incorporation
- ChEMBL_147142 (CHEMBL754174) Binding affinity for gamma-S binding assay; Inactive
- ChEMBL_153232 (CHEMBL764465) Maximum transcriptional activation of human PPAR gamma receptor
- ChEMBL_154518 (CHEMBL764404) Transcriptional activation of peroxisome proliferator activated receptor gamma
- ChEMBL_154539 (CHEMBL760259) Binding affinity for peroxisome proliferator activated receptor gamma
- ChEMBL_1563455 (CHEMBL3783048) Agonist activity at PPAR-gamma receptor (unknown origin)
- ChEMBL_195987 (CHEMBL807693) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_195988 (CHEMBL879244) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_196157 (CHEMBL804930) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_196160 (CHEMBL804933) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_196170 (CHEMBL804943) Transcriptional activation of retinoic acid receptor RAR gamma
- ChEMBL_196178 (CHEMBL804951) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_196667 (CHEMBL803399) Transcriptional activation of Retinoic acid receptor RAR gamma
- ChEMBL_197216 (CHEMBL798964) Transcriptional activation of Retinoid X receptor RXR gamma
- ChEMBL_197219 (CHEMBL798967) Transcriptional activation of Retinoid X receptor RXR gamma
- ChEMBL_197233 (CHEMBL801379) Transcriptional activation of Retinoid X receptor RXR gamma
- ChEMBL_197234 (CHEMBL801380) Effective concentrations against Retinoic acid receptor RXR-gamma
- ChEMBL_197243 (CHEMBL803365) Binding affinity towards Retinoic acid receptor RXR-gamma
- ChEMBL_2267394 Inhibition of human gamma secretase by western blot assay
- ChEMBL_2494610 Agonist activity at full length ERR-gamma (unknown origin)
- ChEMBL_2521088 Inhibition of peroxisome proliferator-activated receptors gamma (unknown origin)
- ChEMBL_305937 (CHEMBL833484) Inhibition of human Peroxisome proliferator activated receptor gamma
- ChEMBL_306190 (CHEMBL830984) In vitro binding affinity for human PPAR gamma
- ChEMBL_320735 (CHEMBL881208) Binding affinity towards peroxisome proliferator activated receptor gamma
- ChEMBL_339279 (CHEMBL868414) Transactivation by human PPAR gamma in COS1 cells
- ChEMBL_643027 (CHEMBL1176541) Binding affinity to human NTR1 by gamma counting
- ChEMBL_643028 (CHEMBL1176542) Binding affinity to human NTR2 by gamma counting
- ChEMBL_68428 (CHEMBL682874) Inhibition of Gamma-aminobutyric acid type B receptor
- ChEMBL_70524 (CHEMBL681081) Binding affinity for retinoic acid receptor RAR gamma
- ChEMBL_70649 (CHEMBL678640) Binding affinity against Gamma-amino-N-butyrate transaminase
- ChEMBL_70659 (CHEMBL678649) Inhibitory activity against Gamma-amino-N-butyrate transaminase
- ChEMBL_951390 (CHEMBL2349764) Inhibition of human FAK using [gamma-33P]ATP
- ChEMBL_154529 (CHEMBL760250) In vitro binding to peroxisome proliferator activated receptor gamma (PPAR gamma) using [3H]-BRL 49653 as radioligand in scintillation proximity assay (SPA)
- ChEMBL_2452108 Inhibition of human recombinant PI3K p110-gamma incubated for 120 mins in presence of [gamma-33P]ATP by radioactivity based scintillation proximity assay
- ChEMBL_68432 (CHEMBL683044) Antagonistic potency against human Gamma-aminobutyric acid A receptor alpha-6-beta-3-gamma-2 expressed in Xenopus oocytes at 1 mM
- ChEMBL_70098 (CHEMBL678328) Antagonistic potency against human Gamma-aminobutyric acid A receptor alpha-1-beta-3-gamma-2 expressed in Xenopus oocytes at 1 mM
- ChEMBL_70106 (CHEMBL681641) Binding affinity to human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2, determined using [3H]-Ro- 15-1788 radioligand
- ChEMBL_70260 (CHEMBL681247) Antagonistic potency against human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in Xenopus oocytes at 1 mM
- ChEMBL_70415 (CHEMBL682250) Antagonistic potency against human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes at 1 mM
- ChEMBL_70538 (CHEMBL681095) Antagonistic potency against human Effective dose for agonist activity on human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2
- ChEMBL_70539 (CHEMBL682901) Antagonistic potency against human Effective dose for agonist activity on human Gamma-aminobutyric acid A receptor alpha-4-beta-3-gamma-2
- ChEMBL_70694 (CHEMBL679477) Antagonistic potency against human Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in Xenopus oocytes at 1 mM
- ChEMBL_1492474 (CHEMBL3528849) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPH
- ChEMBL_1492475 (CHEMBL3528850) Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPH
- ChEMBL_1661001 (CHEMBL4010613) Inhibition of human CYP2C8 using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis
- ChEMBL_2253560 (CHEMBL5167770) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysis
- ChEMBL_303742 (CHEMBL829785) Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expressed in HEK293 cells
- ChEMBL_303743 (CHEMBL829786) Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-2-beta-2-gamma-2 expressed in HEK293 cells
- ChEMBL_303744 (CHEMBL829787) Displacement of [3H]flumazenil from rat GABA-A Gamma-aminobutyric acid A receptor alpha-5-beta-3-gamma-2 expressed in HEK293 cells
- ChEMBL_70266 (CHEMBL681405) Binding affinity to human gamma-amino butyric-acid A receptor alpha-2-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligand
- ChEMBL_70418 (CHEMBL682253) Binding affinity to human gamma-amino butyric-acid A receptor alpha-3-beta-3-gamma-2, using a [3H]-Ro- 15-1788 radioligand
- ChEMBL_1677530 (CHEMBL4027673) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate upto 10 uM after 20 mins in presence of NADPH by LC-MS/MS analysis
- ChEMBL_2124311 (CHEMBL4833544) Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6a-hydroxylation reaction incubated for 30 mins in presence of NADP by LC-MS/MS analysis
- ChEMBL_2093866 (CHEMBL4775129) Inhibition of DNA-PK in human A549 cells assessed as reduction in radiation-induced autophosphorylation at S2056 residue preincubated for 1 hr followed by 8 Gy irradiation and measured after 1 hr by ELISA
- ChEBML_154201 Peroxisome proliferator activated receptor gamma agonistic activity in HepG2 cells.
- ChEBML_154209 In vitro binding affinity for human PPAR gamma in SPA
- ChEBML_68750 Compound was tested for inhibitory potency against gamma-Glutamyl Hydrolase.
- ChEMBL_153619 (CHEMBL760384) Displacement of PPARgamma agonist from human PPAR gamma receptor
- ChEMBL_154051 (CHEMBL760856) Agonistic activity for human Peroxisome proliferator activated receptor gamma
- ChEMBL_161277 (CHEMBL772958) Inhibition of human Protein kinase C gamma with [Ca2+]
- ChEMBL_161286 (CHEMBL766916) Inhibition of Protein kinase C gamma at 1 uM
- ChEMBL_161293 (CHEMBL772101) Binding affinity for Protein kinase C gamma C1a domain
- ChEMBL_161299 (CHEMBL772107) Binding affinity for Protein kinase C gamma C1b domain
- ChEMBL_161305 (CHEMBL772113) Binding affinity for protein kinase C gamma-C1A domain
- ChEMBL_161307 (CHEMBL772115) Binding affinity for protein kinase C gamma-C1B domain
- ChEMBL_1625827 (CHEMBL3868296) Inhibition of PI3K-gamma (unknown origin) by KinaseGlo assay
- ChEMBL_1762450 (CHEMBL4197697) Inhibition of human gamma-secretase by cell based assay
- ChEMBL_1925268 (CHEMBL4428340) Inhibition of gamma secretase (unknown origin) mediated Notch signaling
- ChEMBL_1925288 (CHEMBL4428360) Inhibition of gamma secretase (unknown origin) mediated Notch activation
- ChEMBL_196165 (CHEMBL804938) Inhibition of binding to retinoid A receptor RAR gamma
- ChEMBL_196166 (CHEMBL804939) Dissociation constant for binding to Retinoic acid receptor gamma
- ChEMBL_196331 (CHEMBL801568) Inhibition of [3H]ATRA binding to RAR gamma receptor
- ChEMBL_197227 (CHEMBL798203) Dissociation constant for binding to Retinoid X receptor gamma
- ChEMBL_2019878 (CHEMBL4673691) Inhibition of PI3K-gamma (unknown origin) by HTRF assay
- ChEMBL_2213986 (CHEMBL5127118) Inhibition of ROR gamma (unknown origin) by FRET analysis
- ChEMBL_2538106 Inhibition of human p38-gamma by discoverX kinome scan assay
- ChEMBL_2583448 Inhibition of PI3K gamma (unknown origin) by membrane capture assay
- ChEMBL_302915 (CHEMBL830375) Binding affinity for murine peroxisome proliferator activated receptor gamma
- ChEMBL_302951 (CHEMBL841786) Binding affinity for human peroxisome proliferator activated receptor gamma
- ChEMBL_304205 (CHEMBL829745) Effective concentration against human Peroxisome proliferator activated receptor gamma
- ChEMBL_304215 (CHEMBL829755) Effective concentration for human peroxisome proliferator-activated receptor gamma
- ChEMBL_304468 (CHEMBL832684) Agonist response against human PPAR gamma in transactivation assay
- ChEMBL_306293 (CHEMBL828585) Inhibition of human Peroxisome proliferator activated receptor gamma binding
- ChEMBL_306696 (CHEMBL830853) Inhibition of human peroxisome proliferator activated receptor gamma binding
- ChEMBL_321366 (CHEMBL881510) Inhibitory concentration against mitogen-activated protein kinase p38-gamma
- ChEMBL_327489 (CHEMBL861781) Activity against PPAR gamma in human by FRET assay
- ChEMBL_376900 (CHEMBL871385) Inhibition of gamma secretase expressed in SH-SY5Y cells
- ChEMBL_440752 (CHEMBL889849) Inhibition of gamma secretase-mediated amyloid-beta peptid aggregation
- ChEMBL_447416 (CHEMBL896440) Inhibition of gamma secretase in APP-transfected CHO cells
- ChEMBL_463298 (CHEMBL930799) Inhibition of human gamma secretase in human SHSY5Y cells
- ChEMBL_70647 (CHEMBL678638) Concentration dependent inactivation of Gamma-amino-N-butyrate transaminase
- ChEMBL_70656 (CHEMBL678646) The Dissociation Constant for Gamma-amino-N-butyrate transaminase
- ChEMBL_756564 (CHEMBL1804637) Inhibition of human Nek2 in using [gamma-32P] ATP
- ChEMBL_767530 (CHEMBL1825642) Inhibition of CDK9 by [33P]gamma-ATP incorporation assay
- ChEMBL_789438 (CHEMBL1924414) Displacement of [125I]galanin from GalR1 by gamma counting
- ChEMBL_789439 (CHEMBL1924415) Displacement of [125I]galanin from GalR2 by gamma counting
- ChEMBL_839974 (CHEMBL2090370) Inhibition of PI3K gamma by continuous TR-FRET assay
- ChEMBL_951382 (CHEMBL2349756) Inhibition of YES (unknown origin) using [gamma-33P]ATP
- ChEMBL_951384 (CHEMBL2349758) Inhibition of MLK1 (unknown origin) using [gamma-33P]ATP
- ChEMBL_951385 (CHEMBL2349759) Inhibition of HGK (unknown origin) using [gamma-33P]ATP
- ChEMBL_951386 (CHEMBL2349760) Inhibition of MLCK (unknown origin) using [gamma-33P]ATP
- ChEMBL_951387 (CHEMBL2349761) Inhibition of GCK (unknown origin) using [gamma-33P]ATP
- ChEMBL_951388 (CHEMBL2349762) Inhibition of FGR (unknown origin) using [gamma-33P]ATP
- ChEMBL_951389 (CHEMBL2349763) Inhibition of FYN (unknown origin) using [gamma-33P]ATP
- ChEMBL_951391 (CHEMBL2349765) Inhibition of CHK2 (unknown origin) using [gamma-33P]ATP
- ChEMBL_631389 (CHEMBL1109141) Inhibition of GST-tagged PLK1 expressed in H5 insect cells assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_70250 (CHEMBL682709) Binding affinity towards human gamma-aminobutyric-acid A receptor alpha-2-beta-3-gamma-2 using [3H]Ro-151788 expressed in L(tk-) cells
- ChEMBL_70262 (CHEMBL681249) Displacement of [3H]Ro-151788 from human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 stably expressed in L(tk-) cells
- ChEMBL_70405 (CHEMBL680432) Binding affinity towards human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2 using [3H]Ro-151788 expressed in L(tk-) cells
- ChEMBL_70410 (CHEMBL682824) Effective dose for agonist activity on activity on human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expressed in Xenopus oocytes
- ChEMBL_808454 (CHEMBL1961030) Inhibition of human CDC7/DBF4 expressed using baculovirus expression system assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting
- ChEMBL_1500056 (CHEMBL3584052) Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival after 5 days by MTS assay
- ChEMBL_1668633 (CHEMBL4018521) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 2 to 40 mins followed by NADPH-generating system addition measured after 2 mins
- ChEMBL_2547700 Inhibition of Mps1 in human A2780 cells assessed as abolish in KNL-1 phosphorylation at Thr-875 level and pretreated with 100 nmol/L paclitaxel within 30 mins
- ChEBML_154360 Binding affinity was determined by displacement of 20 nM [3H]- thiazolidinedione from 4 nM biotinylated human Peroxisome proliferator activated receptor gamma (PPAR gamma) ligand binding domain
- ChEMBL_303793 (CHEMBL829842) Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha-1-beta-3-gamma-2 expressed in L(tk-) cells
- ChEMBL_303794 (CHEMBL829843) Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha-2-beta-3-gamma-2 expressed in L(tk-) cells
- ChEMBL_303795 (CHEMBL829844) Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha-3-beta-3-gamma-2 expressed in L(tk-) cells
- ChEMBL_303796 (CHEMBL829845) Displacement of [3H]-Ro- 15-1788 from human gamma-aminobutyric-acid GABA-A receptor alpha-5-beta-3-gamma-2 expressed in L(tk-) cells
- ChEMBL_911966 (CHEMBL3058797) Inhibition of Setaria cervi Gamma-glutamyltranspeptidase using L-gamma-glutamyl-p-nitroanilide as substrate incubated for 15 min prior to substrate addition by spectrophotometric analysis
- ChEMBL_1764605 (CHEMBL4199852) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate pretreated for 5 mins followed by NADPH addition and measured after 10 mins by LC-MS analysis
- ChEMBL_2212604 (CHEMBL5125553) Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis
- ChEBML_154050 Agonist activity against human peroxisome proliferator activated receptor gamma was determined
- ChEBML_154208 In vitro binding affinity against human peroxisome proliferator activated receptor gamma
- ChEBML_196014 Inhibition of [3H]RA to binding Retinoic acid receptor RAR gamma
- ChEBML_68572 Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)
- ChEBML_70657 Apparent dissociation constants for inactivation of Gamma-amino-N-butyrate transaminase
- ChEBML_70671 Binding affinity against Gamma-amino-N-butyrate transaminase in pig brain
- ChEMBL_154209 (CHEMBL759454) In vitro binding affinity for human PPAR gamma in SPA
- ChEMBL_1546996 (CHEMBL3748099) Inhibition of human ALK5 in presence of (33P)gamma ATP
- ChEMBL_1546997 (CHEMBL3748100) Inhibition of human KDR in presence of (33P)gamma ATP
- ChEMBL_1546999 (CHEMBL3748102) Inhibition of human ALK2 in presence of (33P)gamma ATP
- ChEMBL_1762445 (CHEMBL4197692) Inhibition of gamma-secretase (unknown origin) assessed as notch cleavage
- ChEMBL_196164 (CHEMBL804937) Inhibition of binding to murine Retinoic acid receptor RAR gamma
- ChEMBL_196325 (CHEMBL806268) Binding constant for baculovirus-expressed Retinoic acid receptor RAR gamma
- ChEMBL_196327 (CHEMBL806270) In vitro binding affinity for Retinoic acid receptor RAR gamma
- ChEMBL_197224 (CHEMBL798972) Inhibition of binding to murine Retinoid X receptor RXR gamma
- ChEMBL_197225 (CHEMBL798334) Inhibition of binding to murine Retinoid X receptor RXR gamma
- ChEMBL_2422154 Agonist activity at human PPAR gamma by luciferase reporter gene assay
- ChEMBL_2456061 Binding affinity to human DNA polymerase gamma assessed as inhibition constant
- ChEMBL_2544454 Inhibition of PLK1 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544455 Inhibition of PLK2 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544456 Inhibition of PLK3 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544457 Inhibition of FLT3 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544458 Inhibition of MELK (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544459 Inhibition of CK2 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544460 Inhibition of ABL (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_2544461 Inhibition of ACK1 (unknown origin) in presence of [gamma-33P]ATP
- ChEMBL_305529 (CHEMBL828550) Inhibitory activity against Gamma-secretase from APP-transfected CHO cells
- ChEMBL_305707 (CHEMBL827222) In vitro inhibition of human Peroxisome proliferator activated receptor gamma
- ChEMBL_310661 (CHEMBL838008) Maximal intrinsic response against peroxisome proliferator activated receptor gamma transactivation
- ChEMBL_352177 (CHEMBL867852) Displacement of [3H]phorbol 12,13-dibutyrate from PKC gamma-C1A
- ChEMBL_352178 (CHEMBL869658) Displacement of [3H]phorbol 12,13-dibutyrate from PKC gamma-C1B
- ChEMBL_354055 (CHEMBL870009) Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMC
- ChEMBL_430029 (CHEMBL917205) Inhibition of gamma secretase isolated from HeLa cells by ELISA
- ChEMBL_44334 (CHEMBL651610) Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitro
- ChEMBL_589589 (CHEMBL1052142) Inhibition of recombinant CHK2 by [gamma-33P]ATP based assay
- ChEMBL_589590 (CHEMBL1052143) Inhibition of recombinant MET by [gamma-33P]ATP based assay
- ChEMBL_591800 (CHEMBL1041540) Inhibition of TIE2 by [gamma-33-P]ATP based assay
- ChEMBL_643026 (CHEMBL1176540) Displacement of [125I]NT from rat NTR2 by gamma counting
- ChEMBL_665132 (CHEMBL1260395) Inhibition of [3H]PDBu binding to PKC gamma C1A peptide
- ChEMBL_68414 (CHEMBL680330) Effective concentration against Gamma-aminobutyric acid A receptor, alpha 5
- ChEMBL_885943 (CHEMBL2215705) Inhibition of GSK3beta using [gamma-33P]ATP by AlphaScreen analysis