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Found 3 Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM123557'
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataKi:  17nMAssay Description:Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataKi:  17.2nMpH: 7.4Assay Description:The binding assay was performed by a filtration method in a 384 well format. Membranes at a final protein concentration of 6 μg/well were incuba...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucagon receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM123557(US8748624, 43)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed