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Found 2161 with Last Name = 'liang' and Initial = 'g'
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085393((2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-carbamoy...)
Affinity DataKi:  0.5nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085402(4-{4-[3-(5-Carbamimidoyl-2-hydroxy-phenyl)-allylca...)
Affinity DataKi:  0.75nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123781(4-(4-Amino-quinazolin-7-ylmethyl)-1-(6-chloro-benz...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 10 mg/kg peroral doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12596(4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 5 mg/kg peroral doseMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085405(2'-Sulfamoyl-biphenyl-4-carboxylic acid [3-(5-carb...)
Affinity DataKi:  2nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123766(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(1-met...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123788(4-(6-Bromo-benzo[b]thiophene-2-sulfonyl)-1-(1H-pyr...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM12595(4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-1-{[1-(2-...)
Affinity DataKi:  3nMAssay Description:Binding affinity (in vitro) of the compound towards human Coagulation factor X was determined at 10 mg/kg peroral doseMore data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123767(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(1H-py...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123782(4-(6-Chloro-thieno[2,3-b]pyridine-2-sulfonyl)-1-(1...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085390(Biphenyl-3,4'-dicarboxylic acid 3-amide 4'-{[(E)-3...)
Affinity DataKi:  5nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085406((2R,3R)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carba...)
Affinity DataKi:  5nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081009(CHEMBL85938 | Thieno[3,2-b]pyridine-2-sulfonic aci...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13281(4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonyl...)
Affinity DataKi:  6nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085392(Biphenyl-3,4'-dicarboxylic acid 3-amide 4'-{[3-(5-...)
Affinity DataKi:  7nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13279(4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfo...)
Affinity DataKi:  7nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123778(2-{2-[4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-2-...)
Affinity DataKi:  8nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085388(3'-Sulfamoyl-biphenyl-4-carboxylic acid [3-(5-carb...)
Affinity DataKi:  9nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471876(CHEMBL134441)
Affinity DataKi:  10nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085400(4'-Sulfamoyl-biphenyl-4-carboxylic acid [(E)-3-(5-...)
Affinity DataKi:  12nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123765(CHEMBL158689 | {2-[4-(6-Chloro-benzo[b]thiophene-2...)
Affinity DataKi:  18nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085401(CHEMBL421676 | N-[(E)-3-(5-Carbamimidoyl-2-hydroxy...)
Affinity DataKi:  19nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471867(CHEMBL135621)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085396(Biphenyl-4,4'-dicarboxylic acid 4-amide 4'-{[3-(5-...)
Affinity DataKi:  20nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471872(CHEMBL134261)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471871(CHEMBL135304)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471867(CHEMBL135621)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471873(CHEMBL334488)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471867(CHEMBL135621)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471861(CHEMBL423897)
Affinity DataKi:  20nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14058(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Affinity DataKi:  22nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123789(4-(5'-Chloro-[2,2']bithiophenyl-5-sulfonyl)-1-(1H-...)
Affinity DataKi:  23nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50081011(3-[(S)-2-Oxo-3-(thieno[3,2-b]pyridine-2-sulfonylam...)
Affinity DataKi:  26nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471863(CHEMBL422972)
Affinity DataKi:  30nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKallikrein-1(Homo sapiens (Human))
Sanofi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50379838(CHEMBL2011750)
Affinity DataKi:  31nMAssay Description:Inhibition of human kallikrein 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50167517(CHEMBL191546 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  32nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085394(5-Pyridin-2-yl-thiophene-2-carboxylic acid [(E)-3-...)
Affinity DataKi:  37nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085391(CHEMBL302064 | N-[3-(5-Carbamimidoyl-2-hydroxy-phe...)
Affinity DataKi:  38nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123785(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(5-oxy...)
Affinity DataKi:  38nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50167534(CHEMBL370284 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50167531(CHEMBL365527 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  41nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Sw 8 Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471870(CHEMBL337194)
Affinity DataKi:  45nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123770(4-(6-Chloro-benzo[b]thiophene-2-sulfonyl)-1-(1H-py...)
Affinity DataKi:  45nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Bos taurus)
Rh£ne-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM13280(3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-...)
Affinity DataKi:  47nMAssay Description:In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50123775(4-[2-(4-Chloro-phenyl)-ethenesulfonyl]-1-(1H-pyrro...)
Affinity DataKi:  48nMAssay Description:In vitro binding affinity for human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50167524(CHEMBL192963 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  49nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085387(Biphenyl-4-carboxylic acid [(E)-3-(5-carbamimidoyl...)
Affinity DataKi:  51nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Aventis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50167525(CHEMBL193514 | [4-(3-Aminomethyl-phenyl)-piperidin...)
Affinity DataKi:  57nMAssay Description:In vitro inhibitory activity against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Rhone-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50085398(CHEMBL72820 | N-[3-(5-Carbamimidoyl-2-hydroxy-phen...)
Affinity DataKi:  58nMAssay Description:In vitro inhibition of coagulation factor Xa.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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