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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataKi:  0.398nMAssay Description:Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50228247(CHEMBL38017 | LY-197055)
Affinity DataKi:  0.540nMAssay Description:Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50427452(CHEMBL2326941)
Affinity DataKi:  0.631nMAssay Description:Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220990(CHEMBL556179)
Affinity DataKi:  1.40nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220984(CHEMBL554636)
Affinity DataKi:  1.40nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220985(CHEMBL553502)
Affinity DataKi:  1.5nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of rolipram binding to PDE4 from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human VCAM and Ramos cell VLA-4 interactionMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220988(CHEMBL544766)
Affinity DataKi:  1.70nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220989(CHEMBL542299)
Affinity DataKi:  1.80nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50074893(2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50074898(2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...)
Affinity DataKi:  3nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220986(CHEMBL542650)
Affinity DataKi:  3.10nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50074901(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50074901(2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216147(CHEMBL134237)
Affinity DataKi:  4.30nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50219407(CHEMBL84350)
Affinity DataKi:  5nMAssay Description:Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  5nMAssay Description:Activity at Histamine H1 receptor using functional H1 receptor assay on guinea pig ileumMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14381(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  5.20nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50228246(Indolidan)
Affinity DataKi:  5.40nMAssay Description:Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220992(CHEMBL545700)
Affinity DataKi:  5.40nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM50314557((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...)
Affinity DataKi:  5.60nMAssay Description:Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14379(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-tert...)
Affinity DataKi:  5.80nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50074889(1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]- rolipram binding to guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50220991(CHEMBL539265)
Affinity DataKi:  6.5nMAssay Description:Inhibition of rolipram binding to phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215950(CHEMBL55046)
Affinity DataKi:  7nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215392(CHEMBL131565)
Affinity DataKi:  7.5nMAssay Description:Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14382(4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...)
Affinity DataKi:  7.60nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14365(8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...)
Affinity DataKi:  8.90nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14386(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1,1-dimet...)
Affinity DataKi:  9.5nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14378(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-di...)
Affinity DataKi:  9.70nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14369(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  9.80nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50471876(CHEMBL134441)
Affinity DataKi:  10nMAssay Description:Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14368(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...)
Affinity DataKi:  10.3nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14366(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(2-meth...)
Affinity DataKi:  11nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14370(8-{1-[(4-Chlorobenzyl)oxy]-1-methyl-ethyl}-3-[3-cy...)
Affinity DataKi:  11nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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