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TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50149598(CHEMBL3770679)
Affinity DataIC50: 0.0295nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50: 0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50: 0.100nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50375517(CHEMBL411245)
Affinity DataIC50: 0.120nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50517299(CHEMBL4533718)
Affinity DataIC50: 0.140nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP production after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50: 0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 0.209nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50375516(CHEMBL258759)
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50385957(CHEMBL2042297)
Affinity DataIC50: 0.360nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50149597(CHEMBL3771184)
Affinity DataIC50: 0.398nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM21173(DPCPX | CHEMBL183 | 8-cyclopentyl-1,3-dipropyl-2,3...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataIC50: 0.501nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50327343(2-(4-(8-fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-...)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.610nMAssay Description:Displacement of [3H]-DPCPX from human recombinant adenosine A1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50149594(CHEMBL3771208)
Affinity DataIC50: 0.676nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474230(5-(5-amino-7-(4-fluorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50: 0.800nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474237(5-(5-amino-7-(3-chlorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50: 0.800nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474230(5-(5-amino-7-(4-fluorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474237(5-(5-amino-7-(3-chlorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM479527(3-amino-5-(4-fluorophenyl)-6-(3- methyl-3H-benzo[d...)
Affinity DataIC50: 0.900nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM479527(3-amino-5-(4-fluorophenyl)-6-(3- methyl-3H-benzo[d...)
Affinity DataIC50: 0.900nMAssay Description:Binding affinity and specificalities of the compounds against different subtype of human adenosine receptors (hA1, hA2a, hA2b, and hA3) were characte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50375515(CHEMBL410288)
Affinity DataIC50: 0.900nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474221(8-(2,6-dimethylpyridin-4-yl)-7-(4-fluoropheny1)- 2...)
Affinity DataIC50: 1.10nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM21220(CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adeno...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474221(8-(2,6-dimethylpyridin-4-yl)-7-(4-fluoropheny1)- 2...)
Affinity DataIC50: 1.10nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50085658(2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyla...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of cAMP formation in CHO cells expressing adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50327327(2-(4-(4-fluorophenyl)-3-methyl-1-o-tolyl-1H-pyrazo...)
Affinity DataIC50: 1.39nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474238(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (3-...)
Affinity DataIC50: 1.40nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50591171(CHEMBL5174600)
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474238(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (3-...)
Affinity DataIC50: 1.40nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50: 1.70nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50: 1.70nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50591163(CHEMBL3929143)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50225877((2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-((R)-tetrahyd...)
Affinity DataIC50: 1.90nMAssay Description:Agonist activity at adenosine A1 receptor expressed in DDT1 MF2 cells assessed as inhibition of (-)-isoproterenol-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50199697(CHEMBL3980193)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50199620(CHEMBL3916846)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50199719(CHEMBL3918173)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at adenosine A1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474232(5-(5-amino-7-(4-(difluoromethyl)phenyl)-2-((3-f lu...)
Affinity DataIC50: 2.20nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474232(5-(5-amino-7-(4-(difluoromethyl)phenyl)-2-((3-f lu...)
Affinity DataIC50: 2.20nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474223(2-(2,6-difluorobenzyl)-8-(2-(dimethylamino) pyridi...)
Affinity DataIC50: 2.30nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM474223(2-(2,6-difluorobenzyl)-8-(2-(dimethylamino) pyridi...)
Affinity DataIC50: 2.30nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM14487([U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,...)
Affinity DataIC50: 2.30nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50055096(CHEMBL3317576)
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of CCPA-stimulated cAMP level by scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50225880((1S,2R,4S)-2-[9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hyd...)
Affinity DataIC50: 2.5nMAssay Description:Agonist activity at adenosine A1 receptor expressed in DDT1 MF2 cells assessed as inhibition of (-)-isoproterenol-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50591168(CHEMBL5180010)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50375531(CHEMBL427737)
Affinity DataIC50: 2.60nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM25400(cid_657378 | CPA | CHEMBL68738 | (2R,3R,4S,5R)-2-[...)
Affinity DataIC50: 2.70nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A1(Human)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50327337(5-methoxy-2-(3-methyl-1-phenyl-4-(quinoxalin-6-yl)...)
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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