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Found 1991 of ki for UniProtKB: Q9QYN8
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434335(CHEMBL2386729 | US9181275, 3)
Affinity DataKi:  0.0200nM ΔG°:  -14.6kcal/moleT: 2°CAssay Description:To determine the effectiveness of representative compounds of this invention as histamine-3 receptor ligands (H3 receptor ligands), the following tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434335(CHEMBL2386729 | US9181275, 3)
Affinity DataKi:  0.0200nMAssay Description:Binding affinity to histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434337(CHEMBL2386727 | US9181275, 1)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434337(CHEMBL2386727 | US9181275, 1)
Affinity DataKi:  0.0320nM ΔG°:  -14.3kcal/moleT: 2°CAssay Description:To determine the effectiveness of representative compounds of this invention as histamine-3 receptor ligands (H3 receptor ligands), the following tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434336(CHEMBL2386728 | US9181275, 2)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434336(CHEMBL2386728 | US9181275, 2)
Affinity DataKi:  0.0500nM ΔG°:  -14.0kcal/moleT: 2°CAssay Description:To determine the effectiveness of representative compounds of this invention as histamine-3 receptor ligands (H3 receptor ligands), the following tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374104(CHEMBL255962)
Affinity DataKi:  0.0500nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374100(CHEMBL270011)
Affinity DataKi:  0.0500nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50232355((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50232355((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50319536((R)-2-(4-methylpiperidin-1-yl)-6-(2-(2-methylpyrro...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374110(CHEMBL401954)
Affinity DataKi:  0.0800nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50074627(4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...)
Affinity DataKi:  0.0800nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50232355((3aR,6aR)-2-(cyclopropylmethyl)-6-(4-(2-(pyrrolidi...)
Affinity DataKi:  0.100nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50174619(CHEMBL197747 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.110nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50098203(1-{4-[2-(1H-Imidazol-4-yl)-ethylsulfanyl]-phenyl}-...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of [125I]-iodoproxyfan from rat histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50074629(4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50074629(4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...)
Affinity DataKi:  0.120nMAssay Description:In vitro inhibitory activity against Histamine H3 receptor for K+ evoked depolarization-induced release of [3H]-histamine from synaptosomes of rat ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50222968(Cipralisant | GT-2331)
Affinity DataKi:  0.126nMAssay Description:Binding affinity of compound against Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50472544(Iodoproxyfan)
Affinity DataKi:  0.126nMAssay Description:Affinity for histamine H3 receptor in rat cerebral cortex.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50472544(Iodoproxyfan)
Affinity DataKi:  0.126nMAssay Description:Affinity for histamine H3 receptor in rat cerebral cortex.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50444496(CHEMBL3092650)
Affinity DataKi:  0.148nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from rat histamine H3 receptor expressed in HEK293 cells after 45 mins by liquid scintillation spectromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50214615(CHEBI:64177 | Clobenpropit)
Affinity DataKi:  0.158nMAssay Description:Binding affinity against H3 receptor in rat cerebral cortex membranes was evaluated using [3H]N-methyl-histamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374102(CHEMBL402297)
Affinity DataKi:  0.160nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50361235(CHEMBL1934525)
Affinity DataKi:  0.170nMAssay Description:Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  0.180nMAssay Description:Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin...More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50074629(4-[(1R,2R)-2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of [3H]- N-alpha-methylhistamine from histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50099623(4-[2-(4,4-Dimethyl-pent-1-ynyl)-cyclopropyl]-1H-im...)
Affinity DataKi:  0.180nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50352357(CHEMBL558655)
Affinity DataKi:  0.182nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50222968(Cipralisant | GT-2331)
Affinity DataKi:  0.195nMAssay Description:Binding affinity towards rat cortical H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50444491(CHEMBL3092823)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat cerebral cortical tissue membranes after 45 mins by liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50361237(CHEMBL1934527)
Affinity DataKi:  0.200nMAssay Description:Displacement of N-[3H]-methylhistamine from histamine H3 receptor in rat cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50268293((5-(1-cyclobutylpiperidin-4-yloxy)-1-(2,2,2-triflu...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50319552((R)-6-methyl-5-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50091385(1-{4-[3-(1H-Imidazol-4-yl)-propoxy]-phenyl}-ethano...)
Affinity DataKi:  0.260nMAssay Description:Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50174627(CHEMBL199245 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...)
Affinity DataKi:  0.270nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374109(CHEMBL255840)
Affinity DataKi:  0.290nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50352358(CHEMBL558456)
Affinity DataKi:  0.295nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50268291((1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50243638(1-((3aR,6aR)-6-(4-(2-((R)-2-methylpyrrolidin-1-yl)...)
Affinity DataKi:  0.300nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50091373(1-{2-Fluoro-4-[3-(1H-imidazol-4-yl)-propoxy]-pheny...)
Affinity DataKi:  0.300nMAssay Description:Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarization-induced release of [3H]-histamine from rat synaptosomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM22916(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)
Affinity DataKi:  0.300nMAssay Description:Histamine H3 receptor affinity of compound was determined in rat cortical membranes using the H3 selective agonist ligand, [3H]N-alpha-methylhistamin...More data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50374095(CHEMBL255752)
Affinity DataKi:  0.300nMAssay Description:Displacement of N-[3H]methylhistamine from histamine H3 receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50319538((R)-1-(4-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quin...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50319549((R)-5-methyl-4-(6-(2-(2-methylpyrrolidin-1-yl)ethy...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from rat cloned histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM82519(4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicycl...)
Affinity DataKi:  0.316nMAssay Description:Binding affinity towards rat histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434334(CHEMBL2386730 | US9181275, 4)
Affinity DataKi:  0.320nMAssay Description:Binding affinity to histamine H3 receptor in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50434334(CHEMBL2386730 | US9181275, 4)
Affinity DataKi:  0.324nM ΔG°:  -12.9kcal/moleT: 2°CAssay Description:To determine the effectiveness of representative compounds of this invention as histamine-3 receptor ligands (H3 receptor ligands), the following tes...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Abbvie

US Patent
LigandPNGBDBM50074627(4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity at histamine H3 receptor in rat cortical membranes by [3H]-Nalpha-methylhistamine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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