Compile Data Set for Download or QSAR
Found 11 of affinity data for UniProtKB/TrEMBL: Q14749
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576430(CHEMBL4874278)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCc2cccc(c2)C(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H19N5O5S/c19-15-12-16(21-7-20-15)23(8-22-12)17-14(25)13(24)11(28-17)6-29-5-9-2-1-3-10(4-9)18(26)27/h1-4,7-8,11,13-14,17,24-25H,5-6H2,(H,26,27)(H2,19,20,21)/t11-,13-,14-,17-/m1/s1
Affinity DataIC50: 8.60nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576428(CHEMBL4850353)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSc2cccc(c2)C(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H17N5O5S/c18-14-11-15(20-6-19-14)22(7-21-11)16-13(24)12(23)10(27-16)5-28-9-3-1-2-8(4-9)17(25)26/h1-4,6-7,10,12-13,16,23-24H,5H2,(H,25,26)(H2,18,19,20)/t10-,12-,13-,16-/m1/s1
Affinity DataIC50: 150nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576431(CHEMBL4875728)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCc2ccc3ccccc3c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H21N5O3S/c22-19-16-20(24-10-23-19)26(11-25-16)21-18(28)17(27)15(29-21)9-30-8-12-5-6-13-3-1-2-4-14(13)7-12/h1-7,10-11,15,17-18,21,27-28H,8-9H2,(H2,22,23,24)/t15-,17-,18-,21-/m1/s1
Affinity DataIC50: 260nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576433(CHEMBL4869943)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCCc2c[nH]nn2)[C@@H](O)[C@H]1O
Affinity DataIC50: 390nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576434(CHEMBL4849284)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CSCc2cc(O)[nH]n2)[C@@H](O)[C@H]1O
Affinity DataIC50: 640nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576435(CHEMBL4870702)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](Cn2cc(CCC(O)=O)nn2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H18N8O5/c16-13-10-14(18-5-17-13)23(6-19-10)15-12(27)11(26)8(28-15)4-22-3-7(20-21-22)1-2-9(24)25/h3,5-6,8,11-12,15,26-27H,1-2,4H2,(H,24,25)(H2,16,17,18)/t8-,11-,12-,15-/m1/s1
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576429(CHEMBL4857500)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C17H16N6O6/c18-13-9-14(20-5-19-13)23(6-21-9)16-11(25)10(24)12(29-16)15(26)22-8-3-1-2-7(4-8)17(27)28/h1-6,10-12,16,24-25H,(H,22,26)(H,27,28)(H2,18,19,20)/t10-,11+,12-,16+/m0/s1
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576436(CHEMBL4868791)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CN(CCCC(O)=O)CCc2ccccc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H28N6O5/c23-20-17-21(25-12-24-20)28(13-26-17)22-19(32)18(31)15(33-22)11-27(9-4-7-16(29)30)10-8-14-5-2-1-3-6-14/h1-3,5-6,12-13,15,18-19,22,31-32H,4,7-11H2,(H,29,30)(H2,23,24,25)/t15-,18-,19-,22-/m1/s1
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576432(CHEMBL4872017)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CNCCc2ccccc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C18H22N6O3/c19-16-13-17(22-9-21-16)24(10-23-13)18-15(26)14(25)12(27-18)8-20-7-6-11-4-2-1-3-5-11/h1-5,9-10,12,14-15,18,20,25-26H,6-8H2,(H2,19,21,22)/t12-,14-,15-,18-/m1/s1
Affinity DataIC50: 2.07E+5nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50576437(CHEMBL4851408)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(O)=O)CC1
Show InChI InChI=1S/C16H21N7O6/c17-13-9-14(19-6-18-13)23(7-20-9)16-11(27)10(26)12(29-16)15(28)22-3-1-21(2-4-22)5-8(24)25/h6-7,10-12,16,26-27H,1-5H2,(H,24,25)(H2,17,18,19)/t10-,11+,12-,16+/m0/s1
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycine N-methyltransferase(Homo sapiens)
Latvian Institute of Organic Synthesis

Curated by ChEMBL
LigandPNGBDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Show SMILES N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
Affinity DataIC50: 3.16E+5nMAssay Description:Inhibition of N-terminal His-tagged human recombinant Glycine-N-methyltransferase (1 to 295 residues) expressed in Escherichia coli using glycine and...More data for this Ligand-Target Pair