Compile Data Set for Download or QSAR
maximum 50k data
Found 59 Enz. Inhib. hit(s) with all data for entry = 50035302
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataKi:  0.340nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067684(2,2,4-Trimethyl-5-[1-o-tolyl-meth-(Z)-ylidene]-2,5...)
Affinity DataKi:  0.660nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human progesterone receptor; Not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129144((Z)-5-butylidene-9-fluoro-2,2,4-trimethyl-2,5-dihy...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129150(9-Fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1...)
Affinity DataKi:  6.10nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Affinity DataKi:  8nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129153((E)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Affinity DataKi:  17nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129151(9-Fluoro-2,2,4-trimethyl-5-(3-methyl-2-methylene-b...)
Affinity DataKi:  26nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129156((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Affinity DataKi:  45nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129155(5-diphenylmethylene-2,2,4-trimethyl-2,5-dihydro-1H...)
Affinity DataKi: >100nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129154(1-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-az...)
Affinity DataKi: >100nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129147(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Affinity DataKi: >100nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129148(CHEMBL65689 | [9-Fluoro-2,2,4-trimethyl-1,2-dihydr...)
Affinity DataKi: >100nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity against Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50:  37nMAssay Description:Antagonist activity against Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129156((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Affinity DataIC50:  65nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129154(1-[9-Fluoro-2,2,4-trimethyl-1,2-dihydro-6-oxa-1-az...)
Affinity DataIC50:  124nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataIC50:  146nMAssay Description:Antagonist activity at glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50:  177nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataIC50:  180nMAssay Description:Antagonist activity against human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129148(CHEMBL65689 | [9-Fluoro-2,2,4-trimethyl-1,2-dihydr...)
Affinity DataIC50:  243nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Affinity DataIC50:  250nMAssay Description:Antagonist activity against human Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Affinity DataIC50:  250nMAssay Description:Antagonist activity against Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129157((Z)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Affinity DataIC50:  324nMAssay Description:Antagonist activity at glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataIC50:  631nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataIC50:  681nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129147(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Affinity DataIC50:  800nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129153((E)-5-(butan-2-ylidene)-9-fluoro-2,2,4-trimethyl-2...)
Affinity DataIC50:  980nMAssay Description:Binding affinity to human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at mineralocorticoid receptor (hMR); not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity at glucocorticoid (hGR) receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataIC50: >1.00E+3nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129152((6S,8S,10R,14S,15S)-17-Acetyl-6,10-dimethyl-13-(R)...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against human Estrogen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against human Estrogen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129145(9-Fluoro-2,2,4-trimethyl-5-((Z)-3-methyl-but-2-eny...)
Affinity DataIC50: >1.00E+3nMAssay Description:Antagonist activity against Androgen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129146((Z)-5-(bromomethylene)-9-fluoro-2,2,4-trimethyl-2,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against human Estrogen receptor; not activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129155(5-diphenylmethylene-2,2,4-trimethyl-2,5-dihydro-1H...)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129150(9-Fluoro-2,2,4-trimethyl-5-methylene-2,5-dihydro-1...)
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129156((Z)-2-(9-fluoro-2,2,4-trimethyl-1,2-dihydrochromen...)
Affinity DataEC50:  2.70E+3nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129149(5-[1,3]Dithian-2-ylidene-9-fluoro-2,2,4-trimethyl-...)
Affinity DataEC50:  2.10nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129147(5-Cyclohexylmethylene-9-fluoro-2,2,4-trimethyl-2,5...)
Affinity DataEC50:  48nMAssay Description:Effective concentration for agonist activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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