Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50008530
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701(CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-be...)
Affinity DataKi:  0.398nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM104692(US8569311, E-5)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50318701(CHEMBL1083659 | MK-4305 | [(7R)-4-(5-Chloro-1,3-be...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM334973(US11040966, Example 5.36 | US9732075, Example 5.36...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM334973(US11040966, Example 5.36 | US9732075, Example 5.36...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520181(CHEMBL2413522)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50093793(E-2006 | Lemborexant)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520182(CHEMBL3740099)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM154947(US9000029, 26)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520179(CHEMBL4592653)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520180(CHEMBL4590386)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50384416(CHEMBL2111553 | CHEMBL291536 | SB-334867)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(CHEMBL1334465 | SB-408124)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520182(CHEMBL3740099)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520179(CHEMBL4592653)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520181(CHEMBL2413522)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50520180(CHEMBL4590386)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50384416(CHEMBL2111553 | CHEMBL291536 | SB-334867)
Affinity DataKi:  631nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50423648(CHEMBL1334465 | SB-408124)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50434481(CHEMBL2385132 | CHEMBL2385133 | CHEMBL2385134)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM50434481(CHEMBL2385132 | CHEMBL2385133 | CHEMBL2385134)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair