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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  290nM ΔG°:  -37.6kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  640nM ΔG°:  -35.6kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  950nM ΔG°:  -35.8kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233016(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Affinity DataKi:  1.05E+3nM ΔG°:  -35.5kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50382706(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Affinity DataKi:  5.70E+3nM ΔG°:  -31.1kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50382706(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Affinity DataKi:  5.90E+3nM ΔG°:  -31.0kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50382706(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Affinity DataKi:  9.40E+3nM ΔG°:  -28.9kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50382706(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Affinity DataKi:  1.41E+4nM ΔG°:  -27.9kJ/molepH: 6.8 T: 2°CAssay Description:The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240726(US9422261, Compound 4)
Affinity DataIC50:  80nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240723(US9422261, Compound 1)
Affinity DataIC50:  90nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240731(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Affinity DataIC50:  100nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240725(US9422261, Compound 3)
Affinity DataIC50:  200nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473792(1-(3-methyl-2,4-dimethoxyphenyl)-3-(2′,4R...)
Affinity DataIC50:  240nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240724(US9422261, Compound 2)
Affinity DataIC50:  400nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473767(1-(2,4-dihydroxyphenyl)-3-(3',4'-dihydroxyphenyl)-...)
Affinity DataIC50:  500nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473769(1-(2,4-dihydroxyphenyl)-3-(2'-hydroxyphenyl)-1-pro...)
Affinity DataIC50:  700nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473768(1-(2,4-dihydroxyphenyl)-3-(3',4'-dimethoxyphenyl)-...)
Affinity DataIC50:  850nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50248158(CHEMBL450195 | N-butylresorcinol | US8993596, 4-Bu...)
Affinity DataIC50:  1.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233168(N-(2-Hydroxy-ethyl)-3,5-dinitro-benzamide (7))
Affinity DataIC50:  1.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM234394(Polyhydroxy benzophenone, 10)
Affinity DataIC50:  1.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240727(US9422261, Compound 5)
Affinity DataIC50:  1.50E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240729(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50:  2.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233170(N-Hydroxy-4,N-dimethyl-benzamide (9))
Affinity DataIC50:  2.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473770(1-(2,4-dihydroxyphenyl)-3-(2'-methoxyphenyl)-1-pro...)
Affinity DataIC50:  3.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233169(N-(2-Bromo-ethyl)-3,5-dinitro-benzamide (8))
Affinity DataIC50:  3.08E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50198715((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Affinity DataIC50:  3.68E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM240730(US9422261, Unigen resorcinol derivative | US968291...)
Affinity DataIC50:  4.90E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473771(1-(2,4-dihydroxyphenyl)-3-(4'-methoxyphenyl)-1-pro...)
Affinity DataIC50:  6.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM234393(Polyhydroxy benzophenone, 9)
Affinity DataIC50:  6.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50249353(1,1,3-trihydroxybenzophenone | 2,2',4-trihydroxybe...)
Affinity DataIC50:  7.30E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473772(1-(2,4,6-trihydroxyphenyl)-3-(4'-aminophenyl)-1-pr...)
Affinity DataIC50:  8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473773(1-(2,4-dihydroxyphenyl)-3-phenyl-1-propanol | US10...)
Affinity DataIC50:  8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473774(1-(2,4-dihydroxyphenyl)-3-(3'-methoxy-4'-hydroxyph...)
Affinity DataIC50:  8.50E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM234397(Polyhydroxy benzophenone, 15)
Affinity DataIC50:  8.80E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM225847(Polyhydroxy benzophenone, 8 | hsp90_138)
Affinity DataIC50:  1.01E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50234650(2,3,4-trihydroxybenzophenone | CHEMBL1527 | Polyhy...)
Affinity DataIC50:  1.05E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473775(1-(2-hydroxy-4-methoxyphenyl)-3-(3',4',5'-trimetho...)
Affinity DataIC50:  1.10E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233171(N-Ethyl-benzamide (10))
Affinity DataIC50:  1.18E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233166(3-Methyl-2-butenyl-4-hydroxybenzoate (2))
Affinity DataIC50:  1.48E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  1.50E+4nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  1.67E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM234392(Polyhydroxy benzophenone, 6)
Affinity DataIC50:  1.74E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473791(1-(2-methoxy-4-hydroxyphenyl)-3-(2′-hydroxy-...)
Affinity DataIC50:  2.40E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473776(1-(2-hydroxy-4-methoxyphenyl)-3-(2',4'-dimethoxyph...)
Affinity DataIC50:  2.50E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  2.90E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM233167(4-Nitro-phenyl-(4-nitro-2-trifluoromethyl)-benzoat...)
Affinity DataIC50:  2.97E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473777(US10857082, Table 2.11 | l-(2-hydroxy-5-methoxyphe...)
Affinity DataIC50:  3.00E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM241950(Neolitsea aciculata extract, 5)
Affinity DataIC50:  6.70E+4nMpH: 6.8 T: 2°CAssay Description:Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473779(1-(2-hydroxy-4-methoxyphenyl)-3-(2',3',4',5'-tetra...)
Affinity DataIC50:  7.20E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
University of Tehran

LigandPNGBDBM473778(1-(2,4-dihydroxyphenyl)-2-(4'-methoxyphenyl)-1-eth...)
Affinity DataIC50:  7.70E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
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