Compile Data Set for Download or QSAR
Found 17 Enz. Inhib. hit(s) with Target = 'Ephrin type-A receptor 4 [29-209]'
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223311(123C4)
Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Affinity DataKi:  640nM ΔG°:  -35.4kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223301(120H10)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataKi:  960nM ΔG°:  -34.3kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223310(123C7)
Show SMILES COc1ccc2c(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c[nH]c2c1
Affinity DataKi:  1.59E+3nM ΔG°:  -33.1kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223305(123C2)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccccc12
Affinity DataKi:  1.59E+3nM ΔG°:  -33.1kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223300(EphA4-LBC inhibitor, Compound 22)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataKi:  2.14E+3nM ΔG°:  -32.4kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223307(123C3)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(F)cc12
Affinity DataKi:  2.22E+3nM ΔG°:  -32.3kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223308(123C5)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(O)cc12
Affinity DataKi:  2.57E+3nM ΔG°:  -31.9kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223302(123B1)
Show SMILES NCCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataKi:  3.04E+3nM ΔG°:  -31.5kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223309(123C6)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
Affinity DataKi:  3.14E+3nM ΔG°:  -31.4kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223306(123C12)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1cccc2ccccc12
Affinity DataKi:  7.67E+3nM ΔG°:  -29.2kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223303(120G1)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccncc1)C(N)=O
Affinity DataKi:  1.40E+4nM ΔG°:  -27.7kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223304(120G2)
Show SMILES CC(C)(N)C(C)(C)C(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccncc1)C(N)=O
Affinity DataKi:  1.00E+5nM ΔG°:  -22.8kJ/molepH: 7.2 T: 2°CAssay Description:For competitive binding assays, 1 mL of 200 mM EphA4-LBD was pre-incubated with the tested compounds at various concentrations in 98 mL of PBS (pH 7....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223310(123C7)
Show SMILES COc1ccc2c(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c[nH]c2c1
Affinity DataKd:  540nMpH: 6.5 T: 2°CAssay Description:The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223308(123C5)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccc(O)cc12
Affinity DataKd:  2.20E+3nMpH: 6.5 T: 2°CAssay Description:The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223305(123C2)
Show SMILES NCCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCCc1c[nH]c2ccccc12
Affinity DataKd:  1.10E+3nMpH: 6.5 T: 2°CAssay Description:The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223311(123C4)
Show SMILES COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1
Affinity DataKd:  420nMpH: 6.5 T: 2°CAssay Description:The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...More data for this Ligand-Target Pair
TargetEphrin type-A receptor 4 [29-209](Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

LigandPNGBDBM223300(EphA4-LBC inhibitor, Compound 22)
Show SMILES NCCC(=O)N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O
Affinity DataKd:  1.20E+3nMpH: 6.5 T: 2°CAssay Description:The purified EphA proteins (EphA4-LBD, EphA3-LBD, and EphA2-LBD) were dissolved in 50 mM potassium phosphate buffer (pH 6.5) containing 100 mM NaCl. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid