Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50017326
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180555(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180547(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180548(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1...)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180545(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-(2-methyl-...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180550(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180551(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-fluoro-6-(...)
Affinity DataIC50: 1.5nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180554(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenyl-6-(...)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180546(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenyl-8-a...)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180549(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1...)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180553(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-(1-methyl-...)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180545(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-(2-methyl-...)
Affinity DataKi:  100nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180552(2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1...)
Affinity DataIC50: 200nMAssay Description:Displacement of [125I]-labeled substance P from human cloned NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180546(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenyl-8-a...)
Affinity DataKi:  300nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180553(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-(1-methyl-...)
Affinity DataKi:  1.25E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180554(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-phenyl-6-(...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180547(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180548(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-1...)
Affinity DataKi:  1.93E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180550(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180555(2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-6...)
Affinity DataKi: >5.00E+3nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50180551(2-(3,5-bis(trifluoromethyl)benzyloxy)-6-fluoro-6-(...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [35S]-labeled MK499 from cloned hERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed