Compile Data Set for Download or QSAR
maximum 50k data
Found 74 Enz. Inhib. hit(s) with all data for entry = 50026670
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50:  500nMAssay Description:Displacement of radiolabeled dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of adrenergic beta1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of muscarinic M1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of sst4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261907(3-(4-(3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)...)
Affinity DataEC50:  80nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262392(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261909(3-(4-(3-cyclohexyl-1,2,4-oxadiazol-5-yl)piperidin-...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261907(3-(4-(3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)...)
Affinity DataEC50:  951nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261906(3-(4-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)pipe...)
Affinity DataEC50:  2.62E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261797(3-(4-(3-(3-chloropyridin-4-yl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  96nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261730(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  419nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261728(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262565(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  722nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262564(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  910nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262508(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  3.03E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262507(3-((R)-3-((3-(2-chloro-4-fluorophenyl)-1,2,4-oxadi...)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262506(3-((S)-3-((3-(2-chloro-4-fluorophenyl)-1,2,4-oxadi...)
Affinity DataEC50:  1.27E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262450((+/-)-N-((1R,2R)-2-(3-(2-chloro-4-fluorophenyl)-1,...)
Affinity DataEC50:  2.23E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262449(CHEMBL514706 | N-(4-(3-(2-chloro-4-fluorophenyl)-1...)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262448((+/-) N-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxad...)
Affinity DataEC50:  1.56E+3nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262447(CHEMBL477993 | N-(3-(3-(2-chloro-4-fluorophenyl)-1...)
Affinity DataEC50:  472nMAssay Description:Agonist activity at human CB1 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262392(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  559nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262508(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262506(3-((S)-3-((3-(2-chloro-4-fluorophenyl)-1,2,4-oxadi...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262505((+/-)-N-(((1S,2S)-2-(3-(2-chloro-4-fluorophenyl)-1...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262449(CHEMBL514706 | N-(4-(3-(2-chloro-4-fluorophenyl)-1...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB1 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at sst4 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at adrenergic beta1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at dopamine D2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at NK1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at histamine H1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at muscarinic M1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261908(3-(4-(3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl)pipe...)
Affinity DataEC50:  1.55E+3nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261909(3-(4-(3-cyclohexyl-1,2,4-oxadiazol-5-yl)piperidin-...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261910(3-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1...)
Affinity DataEC50:  1.44E+3nMAssay Description:Agonist activity at human CB2 receptor expressed in insect Sf9 cells assessed as effect on Eu-GTP bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262392(3-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-y...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CB2 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50261729(6-chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-o...)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human CB2 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262508(3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-...)
Affinity DataEC50:  17nMAssay Description:Agonist activity at human CB2 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50262506(3-((S)-3-((3-(2-chloro-4-fluorophenyl)-1,2,4-oxadi...)
Affinity DataEC50: >2.00E+3nMAssay Description:Agonist activity at human CB2 receptor assessed as inhibition of forskolin-induced increase in intracellular cAMPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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