Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with all data for entry = 50031435
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50271083BDBM50271083(5-(5-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50227631BDBM50227631(2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)iso...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313205BDBM50313205(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313223BDBM50313223(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 26nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50006805BDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 26nMAssay Description:Inhibition of FLAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313206BDBM50313206(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313207BDBM50313207(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313224BDBM50313224(5-(4-tert-butylphenyl)-1-(4-isopropoxyphenyl)-1H-i...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50168761BDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313222BDBM50313222(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313215BDBM50313215(4,6-Dihydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-ben...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313200BDBM50313200(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313196BDBM50313196(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313199BDBM50313199(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313210BDBM50313210(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 160nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313217BDBM50313217(4,7-Dihydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-ben...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313219BDBM50313219(4-Hydroxy-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313218BDBM50313218(4-Hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1lambda*6...)
Affinity DataIC50: 280nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313197BDBM50313197(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 290nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270594BDBM50270594(4-(3-chlorobenzyl)-2,6-bis(4-(trifluoromethoxy)phe...)
Affinity DataIC50: 390nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313205BDBM50313205(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 420nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313196BDBM50313196(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 460nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313205BDBM50313205(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human mPGES1 in IL-1-beta-stimulated human RASF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313198BDBM50313198(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 530nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313219BDBM50313219(4-Hydroxy-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-...)
Affinity DataIC50: 670nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313210BDBM50313210(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313214BDBM50313214(4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...)
Affinity DataIC50: 690nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313223BDBM50313223(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 750nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313207BDBM50313207(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 760nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313202BDBM50313202(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 860nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313206BDBM50313206(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 920nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313208BDBM50313208(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270616BDBM50270616(7-hydroxy-N1,N3-dimesitylnaphthalene-1,3-disulfona...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313200BDBM50313200(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313214BDBM50313214(4-Hydroxy-6-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50270615BDBM50270615(N-(4-chloro-3-(5-methylbenzo[d]oxazol-2-yl)phenyl)...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313197BDBM50313197(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313215BDBM50313215(4,6-Dihydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-ben...)
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50006805BDBM50006805(CHEMBL29097 | 3-(3-(tert-butylthio)-1-(4-chloroben...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human mPGES1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313225BDBM50313225(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-thiochr...)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313218BDBM50313218(4-Hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1lambda*6...)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313201BDBM50313201(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313222BDBM50313222(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313216BDBM50313216(4-Hydroxy-7-methoxy-1,1-dioxo-1,2-dihydro-1lambda*...)
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313204BDBM50313204(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313225BDBM50313225(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-thiochr...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313202BDBM50313202(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 3.44E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313201BDBM50313201(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 3.91E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313203BDBM50313203(N-(4'-cyano-1,1'-biphenyl-4-yl)-4-hydroxy-2H-1,2-b...)
Affinity DataIC50: 3.96E+3nMAssay Description:Inhibition of human mPGES1 assessed as PGE2 level after 41 sec by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50313199BDBM50313199(4-Hydroxy-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e...)
Affinity DataIC50: 4.24E+3nMAssay Description:Inhibition of human mPGES1 in IL-1beta treated human FF cells assessed as blockade of PGH2 to PGE2 conversion after 50 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
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