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Found 48 Enz. Inhib. hit(s) with all data for entry = 50046937
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140291(CHEMBL3758455)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140291(CHEMBL3758455)
Affinity DataKi:  11nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  22nMAssay Description:Displacement of [125I] alpha bungarotoxin from human alpha7 nACh receptor incubated for 20 secsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140289(CHEMBL3759225)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataKi:  32nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140289(CHEMBL3759225)
Affinity DataKi:  43nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140303(CHEMBL3759863)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140292(CHEMBL3759852)
Affinity DataKi:  71nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140288(CHEMBL3759731)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139124(CHEMBL3759208)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139125(CHEMBL3760021)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142626(CHEMBL3758480)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142625(CHEMBL3758513)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM109773(US8609708, 74 Anabaseine)
Affinity DataKi:  107nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140287(CHEMBL3758648)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139125(CHEMBL3760021)
Affinity DataKi:  127nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142623(CHEMBL3758565)
Affinity DataKi:  155nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139124(CHEMBL3759208)
Affinity DataKi:  158nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142624(CHEMBL3759403)
Affinity DataKi:  194nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140303(CHEMBL3759863)
Affinity DataKi:  204nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140292(CHEMBL3759852)
Affinity DataKi:  343nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142623(CHEMBL3758565)
Affinity DataKi:  384nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140288(CHEMBL3759731)
Affinity DataKi:  394nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142625(CHEMBL3758513)
Affinity DataKi:  429nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139125(CHEMBL3760021)
Affinity DataKi:  609nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142627(CHEMBL3758367)
Affinity DataKi:  680nMAssay Description:Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142626(CHEMBL3758480)
Affinity DataKi:  744nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142626(CHEMBL3758480)
Affinity DataKi:  821nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142623(CHEMBL3758565)
Affinity DataKi:  1.45E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140303(CHEMBL3759863)
Affinity DataKi:  1.77E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142625(CHEMBL3758513)
Affinity DataKi:  1.80E+3nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140287(CHEMBL3758648)
Affinity DataKi:  2.04E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142624(CHEMBL3759403)
Affinity DataKi:  2.08E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140287(CHEMBL3758648)
Affinity DataKi:  2.37E+3nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142624(CHEMBL3759403)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140291(CHEMBL3758455)
Affinity DataKi:  3.79E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140289(CHEMBL3759225)
Affinity DataKi:  5.02E+3nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142627(CHEMBL3758367)
Affinity DataKi:  9.30E+3nMAssay Description:Displacement of [125I] alpha bungarotoxin from rat alpha7 nACh receptor expressed in rat hippocampal membrane preincubated for 30 mins followed by ra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140288(CHEMBL3759731)
Affinity DataKi:  1.15E+4nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50140292(CHEMBL3759852)
Affinity DataKi:  1.88E+4nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50142627(CHEMBL3758367)
Affinity DataKi:  3.20E+4nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139124(CHEMBL3759208)
Affinity DataKi:  3.50E+4nMAssay Description:Displacement of [3H]-epibatidine from rat alpha4beta2 nACh receptor expressed in rat cortical membrane preincubated for 30 mins followed by radioliga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to alpha3beta4 nACh receptor (unknown origin) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139124(CHEMBL3759208)
Affinity DataEC50:  6.00E+4nMAssay Description:Agonist activity at human alpha7 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patch cla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50139124(CHEMBL3759208)
Affinity DataEC50:  2.00E+4nMAssay Description:Agonist activity at human alpha3beta4 nACh receptor expressed in rat GH4C1 cells assessed as increase in current amplitudes after 2 to 3 days by patc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKd:  0.0300nMAssay Description:Binding affinity to alpha4beta2 nACh receptor (unknown origin) expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed