Found 75 Enz. Inhib. hit(s) with all data for entry = 50002722 TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibition of C1s (unknown origin) using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measu...More data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 2(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:Inhibition of recombinant CP1-CCP2-SP fragment of MASP-2 (unknown origin)More data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 1(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Inhibition of recombinant CP1-CCP2-SP fragment of MASP-1 (unknown origin)More data for this Ligand-Target Pair
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of human plasma C1s using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measured ...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Antagonist activity at recombinant human C5aR1 expressed in Sf9 insect cell membranes co-expressing G-alphai2,G-beta1 and G-gamma2 assessed as inhibi...More data for this Ligand-Target Pair
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of C1s (unknown origin) using Cbz-Gly-Arg-S-Bzl as substrate preincubated with substrate for 15 mins followed by enzyme addition and measu...More data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 1(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 65nMAssay Description:Inhibition of MASP-1 (unknown origin) using Z-L-LysSBzl hydrochloride as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 2(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Inhibition of MASP-2 (unknown origin) using Z-L-LysSBzl hydrochloride as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 2(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Inhibition of human His-tagged MASP-2 (Cys300 to Phe686 residues) expressed in baculovirus infected insect cells using Z-Gly-Arg-S-Bzl as substrate p...More data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 2(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataKi: 1.03E+3nMAssay Description:Inhibition of MASP-2 (unknown origin) using Z-L-LysSBzl hydrochloride as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human blood granulocytes assessed as inhibition of recombinant human C5a-induced CD11b expression on granulocytes pre...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human HL60 cells assessed as inhibition of recombinant human C5a-induced oxidative burst after 30 mins by fluorescenc...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followed...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced cell degranulation preincubated for 30 mins ...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human U937 cells assessed as inhibition of recombinant human C5a-induced intracellular calcium mobilization preincuba...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of recombinant human C5a-induced chemotaxis preincubated for 30 mins followe...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human factor B expressed in drosophila cells assessed as decrease in C3a formation using CVF-Bb complex and human complemen...More data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human C5aR1 expressed in Sf9 insect cell membranes co-expressing G-alphai2,G-beta1 and G-gamma2 assessed as inhibi...More data for this Ligand-Target Pair
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human C1s esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Antagonist activity at C5aR1 in human neutrophils assessed as inhibition of 0.1 nM recombinant human C5a-induced intracellular calcium releaseMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Antagonist activity at C5aR1 in HMDM assessed as inhibition of 1 nM recombinant human C5a-induced intracellular calcium release preincubated for 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human factor D expressed in Escherichia coli using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product B...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human factor D using C3b as substrate assessed as decrease in formation of factor B cleavage product BaMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at C5aR1 in HMDMMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of Cy5 from recombinant human biotin labeled factor D expressed in Escherichia coli after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Displacement of Cy5 from recombinant human biotin-labeled factor B expressed in drosophila cells after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human C3aR expressed in RBL-2H3 cells assessed as inhibition of C3a-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human serum C1s using AGLME as substrate after 30 minsMore data for this Ligand-Target Pair
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Antagonist activity at C5aR1 in human PMNMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Displacement of Cy5 from recombinant human biotin-labeled factor B expressed in drosophila cells after 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human factor D using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product Ba by ELISAMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 1(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of MASP-1-mediated C3 deposition in human serum after 30 mins by ELISAMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 1(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of MASP1 (unknown origin)-induced lectin pathway by ELISAMore data for this Ligand-Target Pair
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of human serum C1s-mediated lysis of rabbit Ab-sensitized sheep erythrocytes after 60 minsMore data for this Ligand-Target Pair
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Displacement of 125I-C3a from recombinant human C3aR expressed in HEK293 cell membranes after 3 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of C3 in human serum by ELISAMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 2(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of MASP2 (unknown origin)-induced lectin pathway by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in lysis of human erythrocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on human erythrocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Inhibition of human factor D esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated human serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated rat serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated human serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of factor D in zymogen-activated rat serum assessed as decrease in human erythrocyte lysisMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of C3bi-AP binding to CR3 derived from human PMNMore data for this Ligand-Target Pair
Affinity DataIC50: 144nMAssay Description:Inhibition of factor D in human plasma assessed as decrease in alternative pathway-mediated MAC formation preincubated for 30 mins measured after 30 ...More data for this Ligand-Target Pair
TargetC3a anaphylatoxin chemotactic receptor(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Displacement of 125I-C3a from human C3aR expressed in RBL-2H3 cellsMore data for this Ligand-Target Pair
TargetMannan-binding lectin serine protease 1(Homo sapiens)
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of MASP-1-mediated C3 deposition in human serum after 30 mins by ELISAMore data for this Ligand-Target Pair
