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Found 16 Enz. Inhib. hit(s) with all data for entry = 50009265
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526698(CHEMBL4587815)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 (DE3) cells preincubated for 10 mins followed by arachidonic acid addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526699(CHEMBL4457977)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat 5-LOX expressed in insect sf21 cells preincubated for 4 mins followed by Arachidonic acid addition and measured after 4 mins by FOX...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50383655(CHEMBL2029843)
Affinity DataIC50:  127nMAssay Description:Inhibition of rat 5-LOX expressed in insect sf21 cells preincubated for 4 mins followed by Arachidonic acid addition and measured after 4 mins by FOX...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526701(CHEMBL4461108)
Affinity DataIC50:  170nMAssay Description:Inhibition of human leukocyte 5-LOX using arachidonic acid as substrate by UV/Vis spectrophotometryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526702(CHEMBL4463974)
Affinity DataIC50:  229nMAssay Description:Inhibition of recombinant human 5-LOX expressed in baculovirus-infected insect cells preincubated for 10 mins followed by Arachidonic acid and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50004425(CHEMBL3238207)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-LOX in A23187-stimulated human neutrophils preincubated for 15 mins followed by A23187 stimulation and measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526697(CHEMBL243555)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of recombinant human 5-LOX using Arachidonic acid as substrate by H2DCFD dye based fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50526700(CHEMBL4470709)
Affinity DataIC50:  1.00E+4nMAssay Description:Competitive inhibition of recombinant human 5-LOX expressed in Escherichia coli BL21 cells using Arachidonic acid as substrate by UV absorbanceMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50164168(1,3,4-Eugenol | 1-Hydroxy-2-methoxy-4-allylbenzene...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50369677(CHEMBL4172824)
Affinity DataIC50:  4.69E+4nMAssay Description:Inhibition of 5-LOX (unknown origin) after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50148573((E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-ben...)
Affinity DataIC50:  5.40E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
School Of Advanced Sciences

Curated by ChEMBL
LigandPNGBDBM50318452(3-Allylsulfanyl-propene | CHEMBL170458 | Diallyl s...)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of human PMNL 5-LOX using arachidonic acid as substrate after 5 mins by HPLC methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed