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Found 23 Enz. Inhib. hit(s) with all data for entry = 50007920
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514008(CHEMBL4450581 | US10894782, No 11)
Affinity DataIC50:  7nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activity by biomol green reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514004(CHEMBL4476693)
Affinity DataIC50:  8nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activity by biomol green reagent based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50468108(CHEMBL4280125 | US11247985, Table 3.59)
Affinity DataIC50:  20nMAssay Description:Inhibition of human p97More data for this Ligand-Target Pair
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514013(CHEMBL4445673 | US11247985, Table 3.55)
Affinity DataIC50:  44nMAssay Description:Inhibition of p97 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50500322(CHEMBL3746912)
Affinity DataIC50:  110nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activity by biomol green reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50158906(CHEMBL3785307 | US11247985, Table 3.123)
Affinity DataIC50:  240nMAssay Description:Inhibition of p97 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50500331(CHEMBL3220939)
Affinity DataIC50:  370nMAssay Description:Inhibition of full length p97 (unknown origin) expressed in insect cells assessed as reduction in ATPase activity by NADH-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50514006(CHEMBL4572843)
Affinity DataIC50:  710nMAssay Description:Inhibition of VPS4B (unknown origin) by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50514006(CHEMBL4572843)
Affinity DataIC50:  710nMAssay Description:Inhibition of VPS4B (unknown origin) assessed as reduction in ATPase activity in presence of activating fragment of substrate CHMP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514010(CHEMBL4576291)
Affinity DataIC50:  760nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514014(CHEMBL4458150)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of p97 in human HeLa cells assessed as reduction in p97-dependent UbG76V-GFP degradation incubated for 1 hr by luciferase reporter gene as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50158903(CHEMBL3786710 | US11247985, Table 3.92)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of p97 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514006(CHEMBL4572843)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of p97 (unknown origin) by malachite green assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514005(CHEMBL4078658)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of p97 in HEK293 cells co-expressing GFP and hemagglutinin assessed as reduction in p97-dependent ERAD pathway by immunoblotting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50514011(CHEMBL2047407)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of ClpX (unknown origin) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before ATP addition and measured up to 120 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of p97 (unknown origin) assessed as reduction in ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514005(CHEMBL4078658)
Affinity DataIC50:  1.53E+4nMAssay Description:Inhibition of p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before ATP addition and measured up to 120 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514011(CHEMBL2047407)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of p97 (unknown origin) expressed in Escherichia coli BL21 (DE3) pre-incubated for 10 mins before ATP addition and measured up to 120 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514007(CHEMBL4549090)
Affinity DataIC50:  3.14E+4nMAssay Description:Inhibition of p97 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514009(CHEMBL1613563)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GST-fused VCP (unknown origin) expressed in Escherichia coli BL21 star (DE3) pre-incubated for 60 mins before ATP addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514015(CHEMBL4514514)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to GST-tagged p97 (unknown origin) by CD spectroscopyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransitional endoplasmic reticulum ATPase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514012(CHEMBL3220938)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to p97 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed