Compile Data Set for Download or QSAR
Report error Found 53 Enz. Inhib. hit(s) with all data for entry = 50020221
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627886(CHEMBL5438312)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567822(US11420970, Example 23)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567831(US11420970, Example 32)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567955((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567828(US11420970, Example 29)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567959((R)-1-((R)-3-amino-1-(4-((6-amino-9H-purin-9-yl)me...)
Affinity DataIC50: 1nMAssay Description:Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  10nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627889(CHEMBL5440549)
Affinity DataKd:  14nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 34nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627876(CHEMBL5416709)
Affinity DataKd:  46nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627876(CHEMBL5416709)
Affinity DataKd:  46nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50598859(CHEMBL5200945)
Affinity DataKd:  91nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50594308(CHEMBL5186268)
Affinity DataIC50: 110nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 110nMAssay Description:Inhibition of NSD2 E1099K mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567822(US11420970, Example 23)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 170nMAssay Description:Inhibition of NSD2 T1150A mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 170nMAssay Description:Inhibition of wild type NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant G9a methylation activity expressed in Escherichia coli assessed as effect on H3K9 level by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataIC50: 200nMAssay Description:Antagonist activity against recombinant human GST-tagged NSD3 PWWP1 domain (247 to 398 residues) expressed in Escherichia coli BL21(DE3) incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627886(CHEMBL5438312)
Affinity DataIC50: 214nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567828(US11420970, Example 29)
Affinity DataIC50: 225nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567825(US11420970, Example 26)
Affinity DataIC50: 248nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM567831(US11420970, Example 32)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50562969(CHEMBL4758943)
Affinity DataKd:  349nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627890(CHEMBL5422577)
Affinity DataEC50:  350nMAssay Description:Induction of degradation of NSD2 in human U2OS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627877(CHEMBL5406103)
Affinity DataIC50: 890nMAssay Description:Inhibition of human NSD2 expressed in Escherichia coli BL21 assessed as reduction in H3K36 methylation activity incubated for 4 hrs by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627889(CHEMBL5440549)
Affinity DataEC50:  1.20E+3nMAssay Description:Induction of degradation of NSD2 in human U2OS cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627887(CHEMBL5438496)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627888(CHEMBL5413676)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50555101(CHEMBL4778517)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to human recombinant NSD3 PWWP1 domain assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to GST-tagged human NSD2 assessed as dissociation assMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NSD3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627875(CHEMBL5401805)
Affinity DataKd:  3.40E+3nMAssay Description:Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627882(CHEMBL5427103)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataKd:  4.70E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627880(CHEMBL5418173)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627884(CHEMBL5420895)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627881(CHEMBL5393738)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627883(CHEMBL5402134)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627879(CHEMBL5412139)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataKd:  1.04E+4nMAssay Description:Binding affinity to hexa-histidine tagged NSD1 SET domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627885(CHEMBL5407230)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50627878(CHEMBL5402803)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of NSD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human recombinant NSD2 (2844 to 3717 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human recombinant NSD3 (3084 to 3954 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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