Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50020040
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM258444(US9512130, 2)
Affinity DataIC50: 0.700nMAssay Description:Competitive binding affinity to MPS1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full-length MPS1 (unknown origin) using fluorescein-labeled MBP-derived peptide as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50512459(CHEMBL4581793)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50625769(CHEMBL5419030)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full-length MPS1 (unknown origin) using fluorescein-labeled MBP-derived peptide as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50386816(CHEMBL2047943)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of C-terminal tGFP-tagged full-length human MPS1 expressed in mammalian expression system using myelin basic protein as substrate in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50081552(CHEMBL3422063)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50512458(CHEMBL4450240)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MPS1 in human MDA-MB-468 cells assessed as decrease in phosphorylation of histone H3 at Ser10 incubated for 2 hrs in presence of PF-277...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MPS1 (unknown origin) using MAD1-MAD2 complex as substrate incubated for 1 hr in presence of gamma-[32P]ATP by densitometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50512455(CHEMBL4436510)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of MPS1 in human MDA-MB-468 cells assessed as decrease in phosphorylation of histone H3 at Ser10 incubated for 2 hrs in presence of PF-277...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50625768(CHEMBL5438574)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of full-length MPS1 (unknown origin) using fluorescein-labeled MBP-derived peptide as substrate preincubated for 1 hr followed by substrat...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage-expressed gene 1 protein(Mus musculus)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50081539(CHEMBL3422104)
Affinity DataIC50: 9nMAssay Description:Inhibition of mouse MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM241338(US9409907, 182 | US10479788, Example 182 | US11046...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant MPS1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50625767(CHEMBL5439929)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1/2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50512457(CHEMBL4474534)
Affinity DataIC50: 50nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMacrophage-expressed gene 1 protein(Mus musculus)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50: 55nMAssay Description:Inhibition of mouse MPS1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50625767(CHEMBL5439929)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50625767(CHEMBL5439929)
Affinity DataIC50: 98nMAssay Description:Competitive inhibition of MPS1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetAurora kinase B(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50170831(N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-...)
Affinity DataIC50: 99nMAssay Description:Inhibition of GST-fused AURORA B (1 to 344 residues) expressed in Escherichia coli co-expressing human INCENP assessed as reduction in phosphorylatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDual specificity protein kinase TTK(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50: 182nMAssay Description:Inhibition of full-length MPS1 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed